Tuning interionic interaction for highly selective in vivo analysis

Abstract

The development of highly selective methodologies to enable in vivo recording of chemical signals is of great importance for studying brain functions and brain activity mapping. However, the complexity of cerebral systems presents a great challenge in the development of chem/(bio)sensors that are capable of directly and selectively recording bioactive molecules involved in brain functions. As one of the most important and popular interactions in nature, interionic interaction constitutes the chemical essence of high specificity in natural systems, which inspires us to develop highly selective chem/(bio)sensors for in vivo analysis by precisely engineering interionic interaction in the in vivo sensing system. In this tutorial review, we focus on the recent progress in the tuning of interionic interaction to improve the selectivity of biosensors for in vivo analysis. The type and property of the interionic interaction is first introduced and several strategies to improve the selectivity of the biosensors, including enzyme-based electrochemical biosensors, aptamer-based electrochemical biosensors, and the strategies to recruit recognition molecules are reviewed. We also present an overview of the potential applications of the biosensors for in vivo analysis and thereby for physiological investigations. Finally, we present the major challenges and opportunities regarding the high selectivity of in vivo analysis based on tuning interionic interaction. We believe that this tutorial review provides critical insights for highly selective in vivo analysis and offers new concepts and strategies to understand brain chemistry.

FRET Modulated Signaling: A Versatile Strategy to Construct Photoelectrochemical Microsensors for In Vivo Analysis

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“…[4] Nonetheless, EC sensing is subject to insufficient selectivity due to the coexistence of substances with similar properties in the complicated biological system. [5] Moreover, it is still quite challenging to detect electrochemically non-active species with EC sensors. [6] Another major concern is that the exertion of bias voltage as the excitation source may lead to undesirable electrophysiological stimulation and thus induce non-negligibly abnormal secretion of biomolecules from living systems.…”

Biological Applications of Organic Electrochemical Transistors: Electrochemical Biosensors and Electrophysiology Recording

“…In addition to the high sensitivity, selectivity is another key role for the biological sensors. So far, there are several methods to improve the selectivity by rationally designing the surface chemistry of gate electrode (e.g., modifying special materials and/or modulating the interaction of ions (Yu et al, 2015). Liao et al(Figures 6E,F) (Liao et al, 2015), reported a highly selective OECTs-based enzyme sensors.…”

Observation of Lidocaine‐suppressed Decrease of Magnesium in Salicylate‐induced Tinnitus with an Online Electrochemical System

“…Electrochemical methods have attracted increasing attention monitoring neurochemicals in vivo because selectivity and sensitivity of the methods as well as the anti‐fouling property of the electrode could be principally achieved by rationally designing and constructing electrode/brain interface . By using the online electrochemical system (OECS) developed previously , we herein investigate the effect of lidocaine on the change of Mg 2+ level in IC of guinea pigs following salicylate‐induced tinnitus.…”