Tuning loading and release by modification of micelle core crystallinity and preparation

Glavas, Lidija; Odelius, Karin; Albertsson, Ann‐Christine

doi:10.1002/pat.3524

Cited by 14 publications

(21 citation statements)

References 40 publications

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“…All polymers formed micelles ranging from 25 to 60 nm but only those incorporating DL were amorphous. The study showed that the critical aggregation concentration was higher for amorphous systems and that the loading of aniline pentamer was better in the amorphous vector [132,133]. A similar loading improvement in amorphous vectors for indomethacin was described by Alexander and co-workers [134].…”

Section: Cristallinitysupporting

confidence: 66%

Rational design of block copolymer self-assemblies in photodynamic therapy

Demazeau¹,

Gibot²,

Mingotaud³

et al. 2020

Beilstein J. Nanotechnol.

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Photodynamic therapy is a technique already used in ophthalmology or oncology. It is based on the local production of reactive oxygen species through an energy transfer from an excited photosensitizer to oxygen present in the biological tissue. This review first presents an update, mainly covering the last five years, regarding the block copolymers used as nanovectors for the delivery of the photosensitizer. In particular, we describe the chemical nature and structure of the block copolymers showing a very large range of existing systems, spanning from natural polymers such as proteins or polysaccharides to synthetic ones such as polyesters or polyacrylates. A second part focuses on important parameters for their design and the improvement of their efficiency. Finally, particular attention has been paid to the question of nanocarrier internalization and interaction with membranes (both biomimetic and cellular), and the importance of intracellular targeting has been addressed.

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Section: Cristallinitysupporting

confidence: 66%

Rational design of block copolymer self-assemblies in photodynamic therapy

Demazeau¹,

Gibot²,

Mingotaud³

et al. 2020

Beilstein J. Nanotechnol.

View full text Add to dashboard Cite

show abstract

“…The glass transition temperature (T g ) of the hydrophobic segment has also been shown to have a direct effect on the CMC, micellar stability, and drug release rate [ 124 ]. At temperatures above T g , the CMC value increased with the temperature according to the following equation, ΔG 0 ∼ RTln(CMC), where G 0 and R are the Gibbs standard free energy and the universal gas constant, respectively, and the micelle core is in a liquid-like state.…”

Section: Characteristics Of Diblock Copolymersmentioning

confidence: 99%

Polymeric Micelles of Biodegradable Diblock Copolymers: Enhanced Encapsulation of Hydrophobic Drugs

2018

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Polymeric micelles are potentially efficient in encapsulating and performing the controlled release of various hydrophobic drug molecules. Understanding the fundamental physicochemical properties behind drug–polymer systems in terms of interaction strength and compatibility, drug partition coefficient (preferential solubilization), micelle size, morphology, etc., encourages the formulation of polymeric nanocarriers with enhanced drug encapsulating capacity, prolonged circulation time, and stability in the human body. In this review, we systematically address some open issues which are considered to be obstacles inhibiting the commercial availability of polymer-based therapeutics, such as the enhancement of encapsulation capacity by finding better drug–polymer compatibility, the drug-release kinetics and mechanisms under chemical and mechanical conditions simulating to physiological conditions, and the role of preparation methods and solvents on the overall performance of micelles.

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“…Altering the properties of these copolymers, such as constituent chain length, hydrophilic-lipophilic balance (HLB), and charge, can even further alter a NP’s properties, including hydrodynamic size ( Wittgren et al, 1996 ), shell thickness ( Stubenrauch et al, 2006 ), and exposed peripheral functional groups ( Urbani et al, 2008 ; Pearson et al, 2016 ). This in turn allows further finetuning of drug delivery characteristics, such as API solubility, loading capacity, and release profiles ( Yan et al, 2011 ; Glavas et al, 2015 ). Altogether, this endows polymeric NPs with advantages similar to liposomes (e.g., easy encapsulation and high loading of lipophilic APIs, API protection, enhanced half-life and lowered blood clearance, sustained and controlled release, and the availability of readily modifiable surface end groups for targeting and stealth strategies) while also providing researchers with a more adaptable NP platform for various delivery needs.…”

Section: Nanomedicinementioning

confidence: 99%

Nanoapproaches to Modifying Epigenetics of Epithelial Mesenchymal Transition for Treatment of Pulmonary Fibrosis

et al. 2020

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Idiopathic Pulmonary Fibrosis (IPF) is a chronically progressive interstitial lung that affects over 3 M people worldwide and rising in incidence. With a median survival of 2–3 years, IPF is consequently associated with high morbidity, mortality, and healthcare burden. Although two antifibrotic therapies, pirfenidone and nintedanib, are approved for human use, these agents reduce the rate of decline of pulmonary function but are not curative and do not reverse established fibrosis. In this review, we discuss the prevailing epithelial injury hypothesis, wherein pathogenic airway epithelial cell-state changes known as Epithelial Mesenchymal Transition (EMT) promotes the expansion of myofibroblast populations. Myofibroblasts are principal components of extracellular matrix production that result in airspace loss and mortality. We review the epigenetic transition driving EMT, a process produced by changes in histone acetylation regulating mesenchymal gene expression programs. This mechanistic work has focused on the central role of bromodomain-containing protein 4 in mediating EMT and myofibroblast transition and initial preclinical work has provided evidence of efficacy. As nanomedicine presents a promising approach to enhancing the efficacy of such anti-IPF agents, we then focus on the state of nanomedicine formulations for inhalable delivery in the treatment of pulmonary diseases, including liposomes, polymeric nanoparticles (NPs), inorganic NPs, and exosomes. These nanoscale agents potentially provide unique properties to existing pulmonary therapeutics, including controlled release, reduced systemic toxicity, and combination delivery. NP-based approaches for pulmonary delivery thus offer substantial promise to modify epigenetic regulators of EMT and advance treatments for IPF.

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Tuning loading and release by modification of micelle core crystallinity and preparation

Cited by 14 publications

References 40 publications

Rational design of block copolymer self-assemblies in photodynamic therapy

Rational design of block copolymer self-assemblies in photodynamic therapy

Polymeric Micelles of Biodegradable Diblock Copolymers: Enhanced Encapsulation of Hydrophobic Drugs

Nanoapproaches to Modifying Epigenetics of Epithelial Mesenchymal Transition for Treatment of Pulmonary Fibrosis

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