Tuning Mechanical Properties of Biobased Polymers by Supramolecular Chain Entanglement

Lamm, Meghan E.; Song, Lingzhi; Wang, Zhongkai; Rahman, Anisur; Lamm, Benjamin; Fu, Lin; Tang, Chuanbing

doi:10.1021/acs.macromol.9b01828

Cited by 40 publications

(30 citation statements)

References 53 publications

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“…Such supramolecular interactions between polymers have been shown by Lamm et al, and they significantly improve the tensile strength of polymers resulting in stronger microneedles capable of resisting the compressive force typically encountered during skin insertion. 59 , 60 …”

Section: Resultsmentioning

confidence: 99%

Elucidating the Impact of Surfactants on the Performance of Dissolving Microneedle Array Patches

et al. 2022

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The need for biocompatible polymers capable of dissolving in the skin while exhibiting reasonable mechanical features and delivery efficiency limits the range of materials that could be utilized in fabricating dissolving microneedle array patches (MAPs). The incorporation of additives, such as surfactants, during microneedle fabrication might be an alternative solution to overcome the limited range of materials used in fabricating dissolving MAPs. However, there is a lacuna in the knowledge on the effect of surfactants on the manufacture and performance of dissolving MAPs. The current study explores the role of surfactants in the manufacture and performance of dissolving MAPs fabricated from poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP) loaded with the model drugs, ibuprofen sodium and itraconazole. Three nonionic surfactants, Lutrol F108, Pluronic F88, and Tween 80, in solutions at varying concentrations (0.5, 1.0, and 2.0% w/w) were loaded into these dissolving MAPs. It was discovered that all of the dissolving MAPs that incorporated surfactant displayed a lower reduction in the microneedle height (≈10%) relative to the control formulation (≈20%) when subjected to a compressive force of 32 N. In addition, the incorporation of surfactants in some instances enhanced the insertion profile of these polymeric MAPs when evaluated using ex vivo neonatal porcine skin. The incorporation of surfactant into ibuprofen sodium-loaded dissolving MAPs improved the insertion depth of MAPs from 400 μm down to 600 μm. However, such enhancement was not apparent when the MAPs were loaded with the model hydrophobic drug, itraconazole. Skin deposition studies highlighted that the incorporation of surfactant enhanced the delivery efficiency of both model drugs, ibuprofen sodium and itraconazole. The incorporation of surfactant enhanced the amount of ibuprofen sodium delivered from 60.61% up to ≈75% with a majority of the drug being delivered across the skin and into the receptor compartment. On the other hand, when surfactants were added into MAPs loaded with the model hydrophobic drug itraconazole, we observed enhancement in intradermal delivery efficiency from 20% up to 30%, although this did not improve the delivery of the drug across the skin. This work highlights that the addition of nonionic surfactant is an alternative formulation strategy worth exploring to improve the performance and delivery efficiency of dissolving MAPs.

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Section: Resultsmentioning

confidence: 99%

Elucidating the Impact of Surfactants on the Performance of Dissolving Microneedle Array Patches

et al. 2022

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“…ArTU was in a colloidal state when it was dispered in DMF and a Tyndall phenomenon can be observed (Figure S9). In the initial precross-linking process of PMGS with a low ArTU content, as the DMF solvent evaporates under heating, the ArTU segments can aggregate in the PMGS matrix to form single lamellae via intermolecular hydrogen bonding and conjugated effect. − With increasing ArTU oligomers, these assembled single lamellae attract each other to further aggregate to form large-sized lamellar bundles. However, the further growth of the lamellae were restricted by the cross-linking reaction between ArTU and PMGS, making the lamellar bundles split and branch.…”

Section: Resultsmentioning

confidence: 99%

All-Organic Cross-Linked Polysiloxane-Aromatic Thiourea Dielectric Films for Electrical Energy Storage Application

Liu

Chen

Jiang

et al. 2020

ACS Appl. Energy Mater.

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The development of high-power-density energy storage devices and systems calls for high-dielectric-constant (high-k) polymer films with low dielectric loss. Aromatic polythiourea attracts many interests because of its low dielectric loss and high beakdown strength, whereas the high brittleness significantly limits its application as dielectric films. In this report, flexible high-k films were successfully fabricated by cross-linking aromatic thiourea oligomers with allyl glycidyl ether grafted poly(methylhydrosiloxane) (PMHS). Siloxane segments of PMHS improve the flexibility of the cross-linked dielectric films, and the grafted glycidyl ether side groups of PMHS provide highly polarizable building blocks. Because of the high dipole moment (4.89 D), aromatic thiourea endows the dielectric films with a high dielectric constant. Microphase separation morphology was found within the film, and the self-assembly into layered lamellae contributed to the scatter of high-energy-charge carriers. As a result, the dielectric films exhibit reduced dielectric loss tangent and suppressed leakage current density with a high dielectric constant of above 6, a promissing energy density of 3.15 J/cm3 and a high efficiency of above 87% under an electric field of 350 MV/m.

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“…Chain entanglement plays an important role in determining the mechanical properties of polymers . The entanglement molecular weight ( M e ) is defined as the average molecular weight between topological constraints.…”

Section: Resultsmentioning

confidence: 99%

Strong Autonomic Self-Healing Biobased Polyamide Elastomers

Yuan

Jiang

et al. 2020

Chem. Mater.

Self Cite

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Autonomic self-healing materials can self-heal without external stimuli and exterior agents. However, most of these materials have inferior mechanical strength. We reported a class of biobased polyamide elastomers as strong autonomic self-healing materials. A high density of hydrogen bonds, chain entanglements, and rigid crystalline domains provide these elastomers with high tensile strength (21.4 MPa) and high toughness (37.5 MJ/m 3 ). The coexistence of a dynamic H-bonding network and olefin cross-metathesis in the amorphous matrix dictates the outstanding autonomic self-healing behavior with ∼100% scratch recovery. The self-healed elastomers show a recovery of ultimate tensile strength, elongation at break, and tensile toughness at 87.8%, 109%, and 86.4%, respectively.

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Tuning Mechanical Properties of Biobased Polymers by Supramolecular Chain Entanglement

Cited by 40 publications

References 53 publications

Elucidating the Impact of Surfactants on the Performance of Dissolving Microneedle Array Patches

Elucidating the Impact of Surfactants on the Performance of Dissolving Microneedle Array Patches

All-Organic Cross-Linked Polysiloxane-Aromatic Thiourea Dielectric Films for Electrical Energy Storage Application

Strong Autonomic Self-Healing Biobased Polyamide Elastomers

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