Tuning Microbial Activity via Programmatic Alteration of Cell/Substrate Interfaces

Gulyuk, Alexey V.; LaJeunesse, Dennis; Collazo, Ramón; Ivanisevic, Albena

doi:10.1002/adma.202004655

Cited by 7 publications

(6 citation statements)

References 257 publications

(699 reference statements)

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“…For biodegradable materials, recent progress has revealed that degradation rate can regulate cell differentiation, etc. as a dynamic cue, which is as important as other cell or matrix cues to tune cell behaviors. − The degradation rate of polymers depends on MW, crystallinity, hydrophilicity, etc. , For tissue engineering and tissue regeneration, the biodegradation rate of a material scaffold should match that of the tissue formation. So, biodegradation rate is a basic and critical parameter for any biodegradable material.…”

Section: Discussionmentioning

confidence: 99%

A Facile Composite Strategy to Prepare a Biodegradable Polymer Based Radiopaque Raw Material for “Visualizable” Biomedical Implants

Wang

Chen

et al. 2022

ACS Appl. Mater. Interfaces

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Enabling a biodegradable polymer radiopaque under X-ray is much desired for many medical devices. Physical blending of a present biodegradable polymer and a commercialized medical contrast agent is convenient yet lacks comprehensive fundamental research. Herein, we prepared a biodegradable polymer-based radiopaque raw material by blending poly(L-lactic acid) (PLLA or simply PLA) and iohexol (IHX), where PLA constituted the continuous phase and IHX particles served as the dispersed phase. The strong X-ray adsorption of IHX enabled the composite radiopaque; the hydrolysis of the polyester and the water solubility of the contrast agent enabled the composite biodegradable in an aqueous medium. The idea was confirmed by in vitro characterizations of the resultant composite, in vivo subcutaneous implantation in rats up to 6 months, and the clear visualization of a part of a biodegradable occluder in a Bama piglet under X-ray. We also found that the crystallization of PLA was significantly enhanced in the presence of the solid particles, which should be taken into consideration in the design of an appropriate biomaterial composite because crystallization degree influences the biodegradation rate and mechanical property of a material to a large extent. We further tried to introduce a small amount of poly(vinylpyrrolidone) into the blend of PLA and IHX. Compared to the bicomponent composite, the tricomponent one exhibited decreased modulus and increased elongation at break and tensile strength. This paves more ways for researchers to select appropriate raw materials according to the regenerated tissue and the application site.

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Section: Discussionmentioning

confidence: 99%

A Facile Composite Strategy to Prepare a Biodegradable Polymer Based Radiopaque Raw Material for “Visualizable” Biomedical Implants

Wang

Chen

et al. 2022

ACS Appl. Mater. Interfaces

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“…Many antimicrobial materials, including inorganic and organic, have recently been reported . Inorganic materials, primarily metal and metallic oxides, have attracted significant attention because of their rapid and broad-spectrum antibacterial properties and excellent thermostability. − However, bioaccumulation and significant cytotoxicity of inorganic antibacterial materials have limited their applications in the biomedical field . Among organic materials, antibacterial enzymes and peptides have continued to attract attention because of their apparent biocompatibility and robust biocidal activity. − However, the preparation of antibacterial enzymes or peptides is expensive and challenging extraction processes limit their applications…”

Section: Introductionmentioning

confidence: 99%

Low-Cytotoxicity, Broad-Spectrum Corn Starch-Based Antibacterial Particles that Inhibit Multidrug-Resistant Bacteria

Deng,

Gu,

Zhang

et al. 2023

ACS Appl. Bio Mater.

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Antimicrobial resistance is a serious problem in biomedical applications that seriously increases the risk of medical failure. Therefore, developing highly efficient antibacterial agents that inhibit the growth of multidrug-resistant bacteria is a long-standing research goal. In this report, a low-cytotoxicity and highly efficient alternative to antibiotics was designed and prepared using edible corn starch as the scaffold and 2-hydroxypropyl-trimethylammonium chloride chitosan (HTCC) as the antimicrobial agent. The HTCC/ starch particles were found to have a positively charged surface over a wide pH range and to possess broad-spectrum and highly efficient antimicrobial properties. These particles inhibited the growth of standard Gram-positive and Gram-negative bacteria from the China Pharmacopoeia and a clinical multidrug-resistant bacterial strain. Moreover, after treating the HTCC/starch particles with simulated gastric fluid (SGF, pH 1.2) for 4 h, the growth of clinical multidrug-resistant Escherichia coli (NT 2036) was inhibited effectively, indicating that these particles tolerate a gastric acid environment. Although the mass of SGF-treated HTCC/starch particles required to achieve similar antibacterial activity was ∼20-fold that of chloramphenicol or ampicillin, antibiotic-containing products require considerable amounts of pharmaceutical excipients to prepare. Therefore, the HTCC/starch particles described herein are potentially cost-effective alternatives to antibiotics that resolve the antimicrobial resistance issue, especially for inhibiting the growth of pathogenic intestinal bacteria.

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“…, inhibiting biofilm adhesion. 17–24 Many physicochemical factors play essential roles in different stages of bacterial attachment and biofilm formation. 25 The large number of these variables and factors makes it difficult to hypothesize which physicochemical factors are key in the formation of biofilms.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis enhancement of tropodithietic acid (TDA) antibacterial compound through biofilm formation by marine bacteria Phaeobacter inhibens on micro-structured polymer surfaces

Droumpali,

Liu,

Ferrer-Florensa

et al. 2023

RSC Adv.

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Tuning Microbial Activity via Programmatic Alteration of Cell/Substrate Interfaces

Abstract: The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.202004655. material types along with target microorganisms that will be critical for future research on programmable biointerfacial structures.

Cited by 7 publications

References 257 publications

A Facile Composite Strategy to Prepare a Biodegradable Polymer Based Radiopaque Raw Material for “Visualizable” Biomedical Implants

A Facile Composite Strategy to Prepare a Biodegradable Polymer Based Radiopaque Raw Material for “Visualizable” Biomedical Implants

Low-Cytotoxicity, Broad-Spectrum Corn Starch-Based Antibacterial Particles that Inhibit Multidrug-Resistant Bacteria

Biosynthesis enhancement of tropodithietic acid (TDA) antibacterial compound through biofilm formation by marine bacteria Phaeobacter inhibens on micro-structured polymer surfaces

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