Tuning of single fibers in the cochlear nerve of the alligator lizard: Relation to receptor morphology

Weiß, Thomas; Mulroy, Michael J.; Turner, Robert G.; Pike, C. L.

doi:10.1016/0006-8993(76)90823-4

Cited by 109 publications

(44 citation statements)

References 37 publications

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“…americanus, show frequency shifts with temperat~rè similar ta thos~ reported her~ -1976). Cu~ious1YJ fibres frOm onl1 one 'of the t~ad's t~ a~ditory pap111ae'(th~ amphfbian and bas11ar .…”

supporting

confidence: 76%

Auditory nerve fibre activity in the tokay gecko

1981

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“…americanus, show frequency shifts with temperat~rè similar ta thos~ reported her~ -1976). Cu~ious1YJ fibres frOm onl1 one 'of the t~ad's t~ a~ditory pap111ae'(th~ amphfbian and bas11ar .…”

supporting

confidence: 76%

Auditory nerve fibre activity in the tokay gecko

1981

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“…Most of the techniques used in these two sets of experiments were similar, and technical details of animal surgery, acoustic stimulus generation and response recording are described elsewhere (Weiss, Mulroy, Turner & Pike, 1976;Holton, 1980;Baden-Kristensen & Weiss, 1983;Holton & Weiss, 1983). In brief, the basilar papilla of anaesthetized alligator lizards was exposed by opening and enlarging the round window.…”

Section: Methodsmentioning

confidence: 99%

Frequency selectivity of hair cells and nerve fibres in the alligator lizard cochlea.

Holton¹,

Weiß²

1983

The Journal of Physiology

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SUMMARY1. Receptor potentials of hair cells and spike discharges of cochlear nerve fibres were recorded with micropipettes from the free-standing region of the basilar papilla of anaesthetized alligator lizards in response to tones. In this region the hair-cell stereocilia are free-standing, i.e. they protrude directly into endolymph and are not in contact with a tectorial membrane.2. The frequency selectivity of hair-cell responses was measured by means of isovoltage contours of the d.c. ( VJ) and fundamental-a.c. (V1) component of the receptor potential, i.e. iso-Vo and iso-V1 contours. The frequency selectivity of the nerve-fibre discharge was measured by iso-rate (iso-A0) contours. Iso-V0, iso-V1 and iso-A0 contours are basically V-shaped with a characteristic frequency (c.f.) defined as the frequency at which minimum sound pressure (Pmin) is required to evoke the criterion value of the response.3. Receptor potential iso-V0 contours and neural iso-A0 contours have similar slopes: the mean slopes of the low-frequency sides (dB/decade) are -43 0 and -44-3; the slopes of the high-frequency sides are 85-0 and 802. The band widths of iso-V0 and iso-A0 contours away from c.f. are similar (mean values of Q30dB are 040 and 053, respectively). The band widths of iso-A0 contours near c.f. are narrower than those of iso-V0 contours (mean values of QlodB are 2-34 and 1-20, respectively). However, the shapes of the contours near c.f. depend on the iso-response criteria, and we have not determined whether or not iso-V0 and iso-A0 contours are similar near c.f. The shapes of iso-V1 contours differ from those of iso-V0 and iso-A0 contours.4. Nerve fibre c.f.s are tonotopically organized in the nerve, with lowest c.f.s recorded from fibres innervating the border of free-standing and tectorial regions, a region in which hair-cell stereocilia are longest, and the highest c.f.s recorded from fibres innervating the end of the free-standing region in which hair-cell stereocilia are shortest. The c.f. of nerve-fibre response (and by implication hair-cell response) is, therefore, correlated with the height of the stereociliary tuft.

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“…In this study iso-voltage contours were measured over a frequency range not exceeding 50 Hz-20 kHz with a resolution of 10 points/decade. In order to facilitate comparisons between the frequency selectivity of hair cells and cochlear neurones, the algorithm used to generate the iso-voltage contours was similar to that previously used to measure neural iso-rate contours (Kiang, Moxon & Levine, 1970;Weiss et al 1976;Liberman, 1978;Holton, 1980;Holton & Weiss, 1983). We shall describe the algorithm we used to measure the iso-V0 contours; iso-V, contours were measured in an analogous manner.…”

Section: Stimulus Paradigms and Response Measurementsmentioning

confidence: 99%

“…The anatomy has been well described (Wever, 1965(Wever, , 1971Miller, 1966Miller, , 1973Mulroy, 1974;Nadol, Mulroy, Goodenough ) and the molecular structure of the stereocilia has been investigated (Tilney, DeRosier & Mulroy, 1980;DeRosier, Tilney & Egelman, 1980). Measurements have been made of the distribution of d.c. potentials in the receptor organ (Weiss, Altmann & Mulroy 1978); the composition of the inner-ear lymphs (Peterson, Frishkopf, Lechene, Oman, & Weiss, 1978); motion of middle-ear and inner-ear structures (Weiss, Peake, Ling & Holton, 1978;Peake & Ling, 1980;Rosowski, Lynch & Peake, 1981;Frishkopf, 1981;Frishkopf, DeRosier & Egelman, 1982;Holton & Hudspeth, 1982); electric-potential responses of hair cells and supporting cells in the papilla (Mulroy, Altmann, Weiss & Peake, 1974; Holton & Weiss, 1980;Baden-Kristensen & Weiss, 1982; and 206 RECEPTOR POTENTIALS OF COCHLEAR HAIR CELLS spike discharge patterns ofcochlear-nerve fibres (Weiss, Mulroy, Turner & Pike, 1976;Turner, 1980). The previous studies led to a non-parametric model for the generation of receptor potentials in free-standing hair cells Baden-Kristensen & Weiss, 1983), which was qualitatively consistent with the available experimental data, but a quantitative test of this model requires both systematic measurements of the receptor potential of free-standing hair cells in response to tones and a thorough theoretical study of the model's responses to these stimuli.…”

mentioning

confidence: 99%

Receptor potentials of lizard cochlear hair cells with free‐standing stereocilia in response to tones.

Holton¹,

Weiß²

1983

The Journal of Physiology

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SUMMARY1. Intracellular potentials were recorded with micropipettes from hair cells with free-standing stereocilia in the cochleae of anaesthetized alligator lizards.2. Wave forms of intracellular responses to click stimuli were classified into three types: hair cells, supporting cells, and untuned cells. We studied primarily the responses of hair cells to tonal stimuli.3. For most frequencies, f, and levels, P, of tone-burst stimuli, the response envelope of the receptor potential increases monotonically at the tone-burst onset, and decreases monotonically at tone-burst offset. Overshoot in the envelope of the response at the onset and offset of tone bursts is observed only for tone bursts of low f, high P, and short ( and V' components was measured by means of iso-voltage (iso-V0 and iso-V,)contours. Iso-V0 and iso-V' contours are V-shaped: the maximum sensitivity occurs at a characteristic frequency (c.f. ). The shapes of these contours near the c.f. depend on the values of V0 and V1 at which the contours were measured and are sharper for lower values of V1 and V1. The mean slopes of the low-and high-frequency sides of these contours are: -45-0 and + 85-1 dB/decade for iso-V0 contours (n = 26), and -33'6 and + 103'8 dB/decade for iso-V1 contours (n = 28).6. The receptor potential has non-linear properties. The magnitudes and phase angles of V0, 'l, V2, and V3 receptor-potential components were measured as a function of P for different f. The slopes of level functions (the dependence of log V0 and log V1I on log P) were measured at low levels for different f. T. HOLTON AND T. F. WEISSdiffering from c.f. by more than a half-octave, the slope for VT is between 1 and 2 with a mean of 1P3; the slope for V1 is about 1, i.e. V11 increases approximately linearly with P. For frequencies near c.f., the slopes for V0 and V1 are approximately 0-8 and 0 5, respectively, indicating the presence of a compressive non-linearity. An effect of this frequency-dependent non-linearity is to sharpen the frequency selectivity at lower response magnitudes for f near c.f.7. The receptor potential shows low-pass filtering. Whereas the maximum response magnitude of V0 (i.e. the saturation value measured at high P) does not depend on f, the maximum Vj decreases by approximately 20 dB/decade with increasing f. Values of IIJ1I measured at a constant value of V0 also decline by approximately 20 dB/decade.8. Many of the results are consistent with the predictions of a three-stage model of the generation of the receptor potential. The first stage, which represents the mechanical properties ofthe middle and inner ear, is a linear, time-invariant, band-pass filter; the second stage, which represents mechanoelectric transduction in hair cells, is a zero-memory non-linearity; the third stage, which represents the electrical properties of hair cells, is a linear, time-invariant, low-pass filter. However, the results differ from the model predictions for low-level acoustic stimuli near c.f., and indicate the presence of a frequency-dependent compr...

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Tuning of single fibers in the cochlear nerve of the alligator lizard: Relation to receptor morphology

Cited by 109 publications

References 37 publications

Auditory nerve fibre activity in the tokay gecko

Auditory nerve fibre activity in the tokay gecko

Frequency selectivity of hair cells and nerve fibres in the alligator lizard cochlea.

Receptor potentials of lizard cochlear hair cells with free‐standing stereocilia in response to tones.

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