Tuning the Emulsion Properties Influences the Size of Poly(Caprolactone) Particles for Drug Delivery Applications

Manning, Ashbey N.; Rowlands, Claire E.; Saindon, Hope; Givens, Brittany E.

doi:10.1208/s12248-023-00869-4

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…8 In addition to the EPR effect, naparticle formulations mitigate limitations in bioavailbility, solubility, and absorption compared with free drug. 9,10 A common way to create these nanoformulations is to encapsulate the drug in a polymeric nanoparticle. These formulations can be commonly referred to as drug delivery systems (DDSs).…”

Section: Introductionmentioning

confidence: 99%

“…12 Although not as common for DDS as some of its other aliphatic polyester counterparts such as poly(lactic-co-glycolic acid) (PLGA) or poly(lactic acid) (PLA), it remains a promising polymer for drug delivery due to being highly tunable with diffusion dominating short-term drug release as well as low production cost. 9 Creating Paclitaxel loaded PCL nanoparticles will reduce the current limitations of free Paclitaxel such as its low solubility which will create a more effective treatment option. 13,14…”

Section: Introductionmentioning

confidence: 99%

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Engineering a three-dimensional multilayer multicellular model of endometrial cancer for high throughput drug screening and novel treatment methods

Cadena,

Rowlands,

Buchanan

et al. 2024

Preprint

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Endometrial cancer is one of the most common gynecological cancers in the world, with an estimated 382,000 new cases and 90,000 deaths each year. There is no specific treatment, as the underlying causes of endometrial cancer neoplasia are poorly understood. This study focuses on the development and validation of a three-dimensional (3D)in vitromultilayer, multicellularhydrogel that facilitates drug screening analysis. We hypothesized that a specific combination of natural (collagen type I and IV, fibrinogen, fibronectin, Laminin) and synthetic (GELMA, PEGDA) polymers would maximize microvessel formation and cell invasion. The 3D model incorporates human microvascular endothelial cells (hMVEC) and endometrial cancer cells (HEC-1A) atop hydrogel formulations mimicking cell-specific extracellular matrix components. Using a D-optimal experimental design, 45 hydrogel combinations were generated. The predicted hydrogel formulation to maximize all cell responses enhanced higher microvessel formation and cancer invasion compared to the gold standard Matrigel. Subsequent validation emphasizes the importance of a disease-specific model and cell crosstalk in maximizing microvessel formation and cancer invasion. The optimized 3D model adeptly captures variances in cell responses among endometrial cancer cell lines from distinct stages. Finally, the platform is employed to compare cell viability, microvessel formation, and cancer invasion across Ishikawa, KLE, and HEC-1A cells after Paclitaxel exposure, delivered both as a free drug and loaded in poly(caprolactone) (PCL) nanoparticles. Overall, this study provides a valuable tool for exploring intricate interactions within the tumor microenvironment, offering a holistic understanding of cell responses and fostering the development of targeted therapeutic strategies for endometrial cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Engineering a three-dimensional multilayer multicellular model of endometrial cancer for high throughput drug screening and novel treatment methods

Cadena,

Rowlands,

Buchanan

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

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Nanocellulose in targeted drug delivery: A review of modifications and synergistic applications

Babaei-Ghazvini,

Patel,

Vafakish

et al. 2024

International Journal of Biological Macromolecules

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Properties and Characterization of Nanocellulose

Mishra,

Neeraj

2024

J. Phys.: Conf. Ser.

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In the field of nanotechnology, nanocellulose plays crucial role. Some features of nanocellulose like high surface area, crystallinity, porosity and tensile stress makes remarkable changes in medical and Industrial area. It is known for its biocompatibility, renewability, high aspect ratio, infinitesimal toxicity and sustainability. Nanocellulose can be prepared by microcrystalline cellulose. For the synthesis of nanocellulose, Acid hydrolysis procedure was used. Various methods of characterizations were used for the prepared nanocellulose such as “Fourier transforms infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM) and X-ray diffraction”. Nanocellulose drew the attention of scientists for their biochemical properties due to its physical and chemical structure. Various applications of nanocellulose in different field such as biochemical, waste water management, electronics, packaging, automotive etc.

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Tuning the Emulsion Properties Influences the Size of Poly(Caprolactone) Particles for Drug Delivery Applications

Cited by 4 publications

References 38 publications

Engineering a three-dimensional multilayer multicellular model of endometrial cancer for high throughput drug screening and novel treatment methods

Engineering a three-dimensional multilayer multicellular model of endometrial cancer for high throughput drug screening and novel treatment methods

Nanocellulose in targeted drug delivery: A review of modifications and synergistic applications

Properties and Characterization of Nanocellulose

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