Tuning the Poisson's Ratio of Biomaterials for Investigating Cellular Response

Zhang, Wande; Soman, Pranav; Meggs, Kyle; Qu, Xin; Chen, Shaochen

doi:10.1002/adfm.201202666

Cited by 111 publications

(108 citation statements)

References 57 publications

(65 reference statements)

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“…Vacuum casting technique, three-dimensional imaging, and laser cutting at nano-to macroscale were used in Refs. (139)(140)(141)(142)(143) for tailoring the auxetic patterns on polymers, which are shown in Figure 7.…”

Section: Geometrical Pattern-based Auxetic Polymersmentioning

confidence: 99%

Three decades of auxetic polymers: a review

Bhullar

2015

E-Polymers

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Developments in design and technology in the engineering and medical fields necessitate the use of smart and high-performance materials to meet higher engineering specifications. The general requirements of such materials include a combination of high stiffness and strength with significant weight savings, resistance to corrosion, chemical resistance, low maintenance, and reduced costs. Over the last three decades, it has been demonstrated that auxetic materials offer a huge potential for the fields of engineering, natural sciences, and biomedical engineering, and for many other industries, including the aerospace and defense industries, through their unique deformation mechanism and measured enhancements in mechanical properties. To meet future engineering challenges, auxetic materials are increasingly being recognized as integral components of smart and advanced materials. Although materials with a negative Poisson's ratio have been known since the early 1900s, they did not capture researchers' attention until the late 1980s. Since 1991, these materials have been known as auxetic materials. Since then, their benefits and applications have been expanded to all major classes of materials such as metals, ceramics, polymers, and composites, and they are also now being used in engineering applications. The goal of this review was to present the development of auxetic polymers, which were first fabricated in the form of polyurethane foam approximately three decades ago and are now used in the fabrication of non-woven nano/ micropolymeric structures. This review could provide useful information for the future development of auxetic polymers.

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Section: Geometrical Pattern-based Auxetic Polymersmentioning

confidence: 99%

Three decades of auxetic polymers: a review

Bhullar

2015

E-Polymers

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“…The effective Poisson's ratio could be manipulated through the arrangement of posts or controlling the microstructure of the substrate (Zhang et al, 2013). To understand its effect, numerical simulations were conducted for the singlerigidity substrate case with the effective Poisson's ratio increased to 0.45.…”

Section: Resultsmentioning

confidence: 99%

Simulation of cell-substrate traction force dynamics in response to soluble factors

Liu

2017

Biomech Model Mechanobiol

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Finite element (FE) simulations of contractile responses of vascular muscular thin films (vMTFs) and endothelial cells resting on an array of micro-posts under stimulation of soluble factors were conducted in comparison with experimental measurements reported in literature. Two types of constitutive models were employed in the simulations, i.e. smooth muscle cell type and non-smooth muscle cell type. The time histories of the effects of soluble factors were obtained via calibration against experimental measurements of contractile responses of tissues or cells. The numerical results for vMTFs with micropatterned tissues suggest that the radius of curvature of vMTFs under stimulation of soluble factors is sensitive to width of the micropatterned tissue, i.e. the radius of curvature increases as the tissue width decreases. However, as the tissue response is essentially isometric, the time history of the maximum principal stress of the micropatterned tissues is not sensitive to tissue width. Good agreement has been achieved for predictions of the vasoconstrictor endothelin-1 (ET-1) induced contraction stress between the FE numerical simulation and the experiment based approach of Alford, et al. (2011) for the vMTFs with 40, 60, 80 and 100 µm width patterns. This may suggest the contraction stress is weakly sensitive to the tissue width for these patterns. However, for 20 µm width tissue patterning, the numerical simulation result for contraction stress is less than the average value of experimental measurements, which may suggest the thinner and more elongated spindlelike cells within the 20 µm width tissue patterning have higher contractile output. The constitutive model for nonsmooth muscle cells was used to simulate the contractile response of the endothelial cells. The substrate was treated as an effective continuum. For agonists such as Lysophosphatidic acid (LPA) and vascular endothelial growth factor (VEGF), the deformation of the cell diminishes from edge to centre and the central part of the cell is essentially under isometric state. Numerical studies demonstrated the scenarios that cell polarity can be triggered via manipulation of the effective stiffness and Possion's ratio of the substrate.

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“…Meanwhile, reduced price, has paved the way to the exploration of additive manufacturing as an alternative to traditional 2D fabricating methods typically used before. Except for these printing methods, two-photon polymerization [80][81][82], direct-write techniques [83], inkjet [84], micro-milling [85,86], and bio-printing technologies [87,88] have been widely used as well. More useful information could be found in previous published reviews [28,[89][90][91].…”

Section: D Ice Printingmentioning

confidence: 99%

Chemical and biochemical analysis on lab-on-a-chip devices fabricated using three-dimensional printing

Zhang

2016

TrAC Trends in Analytical Chemistry

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Tuning the Poisson's Ratio of Biomaterials for Investigating Cellular Response

Cited by 111 publications

References 57 publications

Three decades of auxetic polymers: a review

Three decades of auxetic polymers: a review

Simulation of cell-substrate traction force dynamics in response to soluble factors

Chemical and biochemical analysis on lab-on-a-chip devices fabricated using three-dimensional printing

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