Tuning the properties of inorganic nanomaterials for theranostic applications in infectious diseases: Carbon nanotubes, quantum dots, graphene, and mesoporous carbon nanoparticles

Patel, Kapil D.; Patel, Anup Kumar; Kurian, Amal G.; Singh, Rajendra K.; Kim, Hae‐Won

doi:10.1016/b978-0-323-91201-3.00011-6

Cited by 8 publications

(14 citation statements)

References 125 publications

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“…In our previous work, it has been shown that this nano-assembly introduced targeted antibiotic delivery against bacterial infection . This work extends our previous work by utilizing the same nano-assembly, which has been optimized for anticancer drug delivery and contains an engineered core–shell particle, consisting of a drug-entrapped photosensitive core and a stimuli-responsive shell . Gold nanorods (GNRs) were coated with mesoporous silica shells (GM) that enhance drug loading capability .…”

Section: Introductionmentioning

confidence: 63%

“…The chemo-photothermal effect of the nano-assemblies activates apoptotic cell death events, such as increasing ROS production, increasing mitochondrial dysfunction, and finally causing apoptosis through caspase activation. 18 The developed nano-assemblies were tested in vitro and showed a 11-fold increase in effectiveness as compared to free Dox. [(GM@Dox) LI]-PF represents a simple, safe, and effective nanocarrier, which can be used for a combination of targeted drug delivery and PTT treatment.…”

Section: ■ Introductionmentioning

confidence: 99%

“…17 This work extends our previous work by utilizing the same nano-assembly, which has been optimized for anticancer drug delivery and contains an engineered core− shell particle, consisting of a drug-entrapped photosensitive core and a stimuli-responsive shell. 18 Gold nanorods (GNRs) were coated with mesoporous silica shells (GM) that enhance drug loading capability. 18 An anticancer drug doxorubicin (Dox) was loaded into a mesoporous silica shell (GM@Dox).…”

Section: ■ Introductionmentioning

confidence: 99%

“…18 Gold nanorods (GNRs) were coated with mesoporous silica shells (GM) that enhance drug loading capability. 18 An anticancer drug doxorubicin (Dox) was loaded into a mesoporous silica shell (GM@Dox). To reduce the side effects and improve the efficacy and stability of the nano-assemblies, GM@Dox was encapsulated in a liposome.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Then, upon NIR laser irradiation, the heat generated by GNRs and the IR 780 dye melted the thermo-sensitive liposome, and hence, Dox was released in an NIR laser-controlled manner. The chemo-photothermal effect of the nano-assemblies activates apoptotic cell death events, such as increasing ROS production, increasing mitochondrial dysfunction, and finally causing apoptosis through caspase activation . The developed nano-assemblies were tested in vitro and showed a 11-fold increase in effectiveness as compared to free Dox.…”

Section: Introductionmentioning

confidence: 99%

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Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

Patel

Rathnayake

Singh

et al. 2023

ACS Appl. Bio Mater.

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The delivery and accumulation of therapeutic drugs into cancer cells without affecting healthy cells are a major challenge for antitumor therapy. Here, we report the synthesis of a liposomal hybrid gold nano-assembly with enhanced photothermal activity for lung cancer treatment. The core components of the nano-assembly include gold nanorods coated with a mesoporous silica shell that offers an excellent drug-loading surface for encapsulation of doxorubicin. To enhance the photothermal capacity of nano-assembly, IR 780 dye was loaded inside a thermo-sensitive liposome, and then, the core nano-assembly was wrapped within the liposome, and GE-11 peptide and folic acid were conjugated onto the surface of the liposome to give the final nano-assembly [(GM@Dox) LI]-PF. The dual targeting approach of [(GM@Dox) LI]-PF leads to enhanced cellular uptake and improves the accumulation of nano-assemblies in cancer cells that overexpress the epidermal growth factor receptor and folate. The exposure of near-infrared laser irradiation can trigger photothermal-induced structural disruption of the nano-assembly, which allows for the precise and controllable release of Dox at targeted sites. Additionally, chemo-photothermal therapy was shown to be 11 times more effective in cancer cell treatment when compared to Dox alone. Our systematic study suggests that the nano-assemblies facilitate the cancer cells undergoing apoptosis via an intrinsic mitochondrial pathway that can be directly triggered by the chemo-photothermal treatment. This study offers an appealing candidate that holds great promise for synergistic cancer treatment.

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Section: Introductionmentioning

confidence: 63%

Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

Patel

Rathnayake

Singh

et al. 2023

ACS Appl. Bio Mater.

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Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Kurian,

Singh,

Sagar

et al. 2024

Nano-Micro Lett.

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Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients and the healthcare system. Conventional therapies, such as corticosteroids and nonsteroidal anti-inflammatory drugs, are limited in efficacy and associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise in addressing these challenges. NZ-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of hydrogels. The multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and differentiation. This review highlights the current state of the art in NZ-engineered hydrogels (NZ@hydrogels) for anti-inflammatory and skin regeneration applications. It also discusses the underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, the challenges and future directions in this ground, particularly their clinical translation, are addressed. The insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels, offering new possibilities for targeted and personalized skin-care therapies.

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Multifunctional Molybdenum-Based Nanoclusters Engineered Gelatin Methacryloyl as In Situ Photo-Cross-Linkable Hybrid Hydrogel Dressings for Enhanced Wound Healing

Kurian,

Mandakhbayar,

Singh

et al. 2024

ACS Appl. Mater. Interfaces

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Tuning the properties of inorganic nanomaterials for theranostic applications in infectious diseases: Carbon nanotubes, quantum dots, graphene, and mesoporous carbon nanoparticles

Cited by 8 publications

References 125 publications

Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Multifunctional Molybdenum-Based Nanoclusters Engineered Gelatin Methacryloyl as In Situ Photo-Cross-Linkable Hybrid Hydrogel Dressings for Enhanced Wound Healing

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