Tuning the properties of porous chitosan: Aerogels and cryogels

Chartier, Coraline; Buwalda, Sytze J.; Berghe, Hélène Van Den; Nottelet, Benjamin; Budtova, Tatiana

doi:10.1016/j.ijbiomac.2022.01.042

Cited by 56 publications

(29 citation statements)

References 40 publications

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“…Recently, Chartier et al (2022) obtained cryogels by freeze-drying, and aerogels by supercritical CO 2 drying as chitosan-based porous materials. Cryogels possessed a lower density, a lower specific area, by a higher porosity in comparison to aerogels [ 62 ]. The freeze-thawing method generally involves preparing the wet-gel, freezing of wet-gel, and thawing the frozen system, respectively [ 63 ].…”

Section: Polysaccharide-based Edible Gels: Formulation Properties And...mentioning

confidence: 99%

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Polysaccharide-Based Edible Gels as Functional Ingredients: Characterization, Applicability, and Human Health Benefits

Pascuta

Varvara

Teleky

et al. 2022

Gels

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Nowadays, edible materials such as polysaccharides have gained attention due to their valuable attributes, especially gelling property. Polysaccharide-based edible gels (PEGs) can be classified as (i) hydrogels, (ii) oleogels and bigels, (iii) and aerogels, cryogels and xerogels, respectively. PEGs have different characteristics and benefits depending on the functional groups of polysaccharide chains (e.g., carboxylic, sulphonic, amino, methoxyl) and on the preparation method. However, PEGs are found in the incipient phase of research and most studies are related to their preparation, characterization, sustainable raw materials, and applicability. Furthermore, all these aspects are treated separately for each class of PEG, without offering an overview of those already obtained PEGs. The novelty of this manuscript is to offer an overview of the classification, definition, formulation, and characterization of PEGs. Furthermore, the applicability of PEGs in the food sector (e.g., food packaging, improving food profile agent, delivery systems) and in the medical/pharmaceutical sector is also critically discussed. Ultimately, the correlation between PEG consumption and polysaccharides properties for human health (e.g., intestinal microecology, “bridge effect” in obesity, gut microbiota) are critically discussed for the first time. Bigels may be valuable for use as ink for 3D food printing in personalized diets for human health treatment. PEGs have a significant role in developing smart materials as both ingredients and coatings and methods, and techniques for exploring PEGs are essential. PEGs as carriers of bioactive compounds have a demonstrated effect on obesity. All the physical, chemical, and biological interactions among PEGs and other organic and inorganic structures should be investigated.

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Section: Polysaccharide-based Edible Gels: Formulation Properties And...mentioning

confidence: 99%

“… TiO 2 —titanium dioxide, BET—Brunauer, Emmett et Teller method, N/A—not determined. Adapted according to [ 9 , 29 , 62 , 67 , 68 , 69 ]. …”

Section: Figurementioning

confidence: 99%

Polysaccharide-Based Edible Gels as Functional Ingredients: Characterization, Applicability, and Human Health Benefits

Pascuta

Varvara

Teleky

et al. 2022

Gels

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“…Bioaerogels combine the properties of classical aerogels (inorganic or synthetic polymer), such as low density and very high internal pores surface area (above 100 m 2 /g), with the advantages of natural polysaccharides, making them very promising materials in life science applications . One such application discussed in the recent literature is the use of bioaerogels based on pectin, , cellulose, , chitosan, , alginate, , and starch , as drug delivery carriers. High surface area provides space for targeted functionalization and tuning drug adsorption and release.…”

Section: Introductionmentioning

confidence: 99%

Starch Alcogels, Aerogels, and Aerogel-like Xerogels: Adsorption and Release of Theophylline

Zou

Budtova

2023

ACS Sustainable Chem. Eng.

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Starch is one of the most abundant and biodegradable natural polysaccharides; it has been widely used in pharmaceutics in tablets, as a disintegrant, or as a porous carrier. In this work, starches in different formsalcogels, aerogels, and low-vacuum-dried materials (named xerogels)were designed and tested as carriers of theophylline. The influence of the starch amylose/amylopectin ratio, concentration in solution, retrogradation time, and drying method (supercritical CO2 drying for aerogels, low-vacuum drying for xerogels) on materials’ density, specific surface area, and morphology was investigated. The precursors before drying were starch alcogels made by water-to-ethanol exchange in retrograded hydrogels. Starch alcogels were loaded with theophylline via impregnation. Loading capacities and efficiencies of alcogels, aerogels, and xerogels were determined, and release of the drug from xerogels and aerogels was evaluated. Two remarkable phenomena were obtained: (1) The low-vacuum drying method resulted in starch aerogel-like materials; i.e., xerogels with low densities and specific surface areas above 100 m2/g. (2) Starch alcogels adsorbed theophylline from ethanol resulting in loading efficiency as high as 250%. The results obtained show a new pathway in making aerogel-like polysaccharide materials without drying in supercritical conditions for potential use as drug carriers.

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“…Previously, we described the influence of drying conditions (sc drying versus freeze-drying) on the physicochemical properties of non-cross-linked chitosan porous materials . In the current manuscript, we investigate the release kinetics of the hydrophilic drug dexamethasone sodium phosphate, a synthetic corticosteroid with anti-inflammatory effects, from chitosan aerogels and cryogels prepared from the same precursor (i.e., chitosan hydrogel).…”

Section: Introductionmentioning

confidence: 99%

Release Kinetics of Dexamethasone Phosphate from Porous Chitosan: Comparison of Aerogels and Cryogels

et al. 2023

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Porous chitosan materials as potential wound dressings were prepared via dissolution of chitosan, nonsolvent-induced phase separation in NaOH−water, formation of a hydrogel, and either freeze-drying or supercritical CO 2 drying, leading to "cryogels" and "aerogels", respectively. The hydrophilic drug dexamethasone sodium phosphate was loaded by impregnation of chitosan hydrogel, and the release from cryogel or aerogel was monitored at two pH values relevant for wound healing. The goal was to compare the drug-loading efficiency and release behavior from aerogels and cryogels as a function of the drying method, the materials' physicochemical properties (density, morphology), and the pH of the release medium. Cryogels exhibited a higher loading efficiency and a faster release in comparison with aerogels. A higher sample density and lower pH value of the release medium resulted in a more sustained release in the case of aerogels. In contrast, for cryogels, the density and pH of the release medium did not noticeably influence release kinetics. The Korsmeyer−Peppas model showed the best fit to describe the release from the porous chitosan materials into the different media.

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Tuning the properties of porous chitosan: Aerogels and cryogels

Cited by 56 publications

References 40 publications

Polysaccharide-Based Edible Gels as Functional Ingredients: Characterization, Applicability, and Human Health Benefits

Polysaccharide-Based Edible Gels as Functional Ingredients: Characterization, Applicability, and Human Health Benefits

Starch Alcogels, Aerogels, and Aerogel-like Xerogels: Adsorption and Release of Theophylline

Release Kinetics of Dexamethasone Phosphate from Porous Chitosan: Comparison of Aerogels and Cryogels

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