Tuning the thermal sensitivity of β-NaYF4: Yb3+, Ho3+, Er3+ nanothermometers for optimal temperature sensing in OTN-NIR (NIR II/III) biological window

Wortmann, Laura; Suyari, Satoru; Ube, Takuji; Kamimura, Masao; Soga, Kohei

doi:10.1016/j.jlumin.2018.01.049

Cited by 65 publications

(27 citation statements)

References 40 publications

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“…While the NaYF 4 NPs emitted in the OTN-NIR range under 980-nm laser excitation, higher intensity Ho 3+ emission was obtained in comparison with that of our previous report 33 because we changed the dopant rare-earth concentration; previously Yb 3+ , Ho 3+ , and Er 3+ concentrations of 20, 1, and 1 mol% were used, while in this work they were at 20, 3, and 0.5 mol%, respectively, as optimized according to a recently published work 34 . The maximum S R of the optimized NPs is 1.87 × 10 −2 °C −1 .…”

Section: Discussionmentioning

confidence: 47%

“…1 . After several trials 34 , the Yb 3+ , Ho 3+ , and Er 3+ concentrations were respectively fixed at 20, 3, and 0.5 mol%. The NP surface was capped by oleic acid (OA) and they were dispersed in cyclohexane.…”

Section: Resultsmentioning

confidence: 99%

“…The maximum S R of the optimized NPs is 1.87 × 10 −2 °C −1 . While other rare-earth-based LNThs operating in the OTN-NIR wavelength region (NIR-II and NIR-III) were reported recently 31 , 32 , 34 , 39 – 42 (Table 2 ), we designed NaYF 4 NPs only operating under 980-nm laser excitation in the OTN-NIR wavelength range. Indeed, most of the previously reported nanothermometers could be excited by 800-nm laser light, the absorption of which by water in biological tissues is relatively less than the absorption of the 980-nm laser light.…”

Section: Discussionmentioning

confidence: 99%

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Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

Sekiyama

Umezawa

Kuraoka

et al. 2018

Sci Rep

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Luminescence nanothermometry has attracted much attention as a non-contact thermal sensing technique. However, it is not widely explored for in vivo applications owing to the low transparency of tissues for the light to be used. In this study, we performed biological temperature sensing in deep tissues using β-NaYF4 nanoparticles co-doped with Yb3+, Ho3+, and Er3+ (NaYF4: Yb3+, Ho3+, Er3+ NPs), which displayed two emission peaks at 1150 nm (Ho3+) and 1550 nm (Er3+) in the >1000 nm near-infrared wavelength region, where the scattering and absorption of light by biological tissues are at the minimum. The change in the luminescence intensity ratio of the emission peaks of Ho3+ and Er3+ (IHo/IEr) in the NaYF4: Yb3+, Ho3+, Er3+ nanothermometer differs corresponding to the thickness of the tissue. Therefore, the relationship between IHo/IEr ratio and temperature needs to be calibrated by the depth of the nanothermometer. The temperature-dependent change in the IHo/IEr was evident at the peritoneal cavity level, which is deeper than the subcutaneous tissue level. The designed experimental system for temperature imaging will open the window to novel luminescent nanothermometers for in vivo deep tissue temperature sensing.

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Section: Discussionmentioning

confidence: 47%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

Sekiyama

Umezawa

Kuraoka

et al. 2018

Sci Rep

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“…In addition, the active‐core/active‐shell Nd 3+ ‐ and Yb 3+ ‐codoped LaF 3 nanoparticles have been utilized for subcutaneous thermal relaxation monitoring with excitation at 808 nm and a ratiometric temperature readout in NIR‐II window . Despite recent advances, NIR lanthanide thermal probes with high sensitivity remain elusive, in particular, in NIR‐II and/or NIR‐III windows that have higher penetration depth and null autofluorescence from endogenous pigmentations …”

Section: Introductionmentioning

confidence: 99%

NIR‐II/III Luminescence Ratiometric Nanothermometry with Phonon‐Tuned Sensitivity

Jia

et al. 2020

Advanced Optical Materials

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Luminescence nanothermometers are promising for noninvasive, high resolution thermographics ranging from aeronautics to biomedicine. Yet, limited success has been met in the NIR‐II/III biological windows, which allow temperature evaluation in deep tissues. Herein, a new type of phonon‐based ratiometric thermometry is described that utilizes the luminescence intensity ratio (LIR) between holmium (Ho3+) emission at ≈1190 nm (NIR‐II) and erbium (Er3+) emission at ≈1550 nm (NIR‐III) from a set of oxide nanoparticles of varying host lattices. It is shown that multi‐phonon relaxation in Er3+ ions and phonon‐assisted transfer process in Ho3+ ions play a significant role in LIR determination through channeling the harvested excitation energy to the corresponding emitting states. As a result, temperature sensitivity can be tuned by the dominant phonon energy of host lattice, thus endowing aqueous yttrium oxide (Y2O3, 376 cm−1) nanoparticles to have a relative temperature sensitivity of 1.01% K−1 and absolute temperature sensitivity of 0.0127 K−1 at 65 °C in a physiological temperature range (25–65 °C). And their temperature sensing for biological tissues is further explored and the influence of water and chicken breast on thermometry is discussed. This work constitutes a solid step forward to build sensitive NIR‐II/III nanothermometers for biological applications.

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“…For instance, Ximendes et al defined the thermo-metric parameter as the ratio between the emission intensities of Yb 3 + at 1000 nm, and Er 3 + at 1550 nm. [21] The ratios between the Ho 3 + and Er 3 + , [22,23] and Er 3 + and Nd 3 + , [24] near-infrared emissions have also been used for temperature sensing.We have been interested in the exploration of new rareearth silicates, including dense, layered and microporous materials, that emit in the visible and near-infrared spectral ranges. [25][26][27] Some of the reported luminescence properties are unique.…”

mentioning

confidence: 99%

Near‐Infrared Ratiometric Luminescent Thermometer Based on a New Lanthanide Silicate

Ananias

Paz

Carlos

et al. 2018

Chemistry A European J

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A new lanthanide silicate system, Na K[Ln Si O ] (Ln=Lu, Yb/ Er, Lu/Eu, or Lu/Yb/Er), comprising microcrystals embedded in an amorphous siliceous matrix, obtained by sintering at 1373 K a Na K[Ln Si O ]⋅3 H O nano-crystalline precursor, is reported. The crystal structure of these lanthanide silicates was solved from high-resolution synchrotron power X-ray diffraction data collected at 110 K, and further supported by Si MAS NMR and Eu luminescence. The materials crystallize in the Pī triclinic centrosymmetric space group, exhibiting a dense framework consisting of hexameric [Si O ] cyclosilicate units, and chains of two distinct {LnO } octahedra. Na K[(Lu Yb Er ) Si O ] is the first example of a lanthanide silicate operative as a near-infrared ratiometric luminescent thermometer, with good sensitivity at cryogenic temperatures (<100 K). Upon excitation at 903 nm, the ratio between the F → F (Yb ) and I → I (Er ) emissions was used for sensing temperature in the 12-450 K range, reaching a maximum thermal sensitivity of 2.6 % K at 26.8 K.

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Tuning the thermal sensitivity of β-NaYF4: Yb3+, Ho3+, Er3+ nanothermometers for optimal temperature sensing in OTN-NIR (NIR II/III) biological window

Cited by 65 publications

References 40 publications

Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

Temperature Sensing of Deep Abdominal Region in Mice by Using Over-1000 nm Near-Infrared Luminescence of Rare-Earth-Doped NaYF4 Nanothermometer

NIR‐II/III Luminescence Ratiometric Nanothermometry with Phonon‐Tuned Sensitivity

Near‐Infrared Ratiometric Luminescent Thermometer Based on a New Lanthanide Silicate

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