Tunneling nanotubes: The intercellular conduits contributing to cancer pathogenesis and its therapy

Melwani, Pooja Kamal; Pandey, Badri Narain

doi:10.1016/j.bbcan.2023.189028

Cited by 10 publications

(2 citation statements)

References 123 publications

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“…Direct long-distance communication in the TME takes place through tunneling nanotubes, known as intercellular bridges. Due to the extension of the cytoplasm formed by F-actin fibers, these structures form thin conduits, transporting larger particles and even cellular organelles (such as mitochondria and lysosomes) [21,22]. They ensure communication not only between normal cells, such as macrophages [23] or T lymphocytes [24], but also between immune cells and cancer cells, initiating metastatic phenotype in tumors [25].…”

Section: Direct Communication In the Tumor Microenvironmentmentioning

confidence: 99%

Characteristics of the Colorectal Cancer Microenvironment—Role in Cancer Progression and Therapeutic Possibilities

Pieniądz,

Pięt,

Paduch

2024

Applied Sciences

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Colorectal cancer (CRC) is one of the most common and deadliest cancers worldwide. According to the GLOBOCAN (WHO) report in 2020, nearly 2 million patients were diagnosed globally. Despite the advances in cancer diagnosis and therapy, CRC remains a global challenge. Recently, attention has been paid to the tumor microenvironment (TME), which constitutes a significant part of the tumor and mainly includes various immune cells, fibroblasts, vascular cells, and extracellular elements, such as the extracellular matrix (ECM). Many components of the stroma initially exert an anti-tumor effect, but over time, they undergo functional transformation into elements that promote tumor growth. As a result, conditions conducive to further cancer development, invasion into local tissues, and distant metastasis arise. The microenvironment of colorectal cancer (CRC) may be an important direction in the search for therapeutic targets, but it requires further understanding. The main purpose of our review is to explain the role of the complex CRC microenvironment in the progression of this cancer and highlight the potential of targeted therapy directed at the TME. Therefore, continued research into its components and typical biomarkers is necessary to improve therapy and enhance the quality of life for patients.

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Section: Direct Communication In the Tumor Microenvironmentmentioning

confidence: 99%

Characteristics of the Colorectal Cancer Microenvironment—Role in Cancer Progression and Therapeutic Possibilities

Pieniądz,

Pięt,

Paduch

2024

Applied Sciences

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“…Finally, Miro GTPases were found to regulate the transport of mitochondria between cells through tunneling nanotubes (TNTs). This type of structure allows intercellular transport, not only for soluble small molecules but also for organelles such as lysosomes and mitochondria [41]. Studies on a mouse model using mesenchymal stem cells (MSC) as donor cells and airway epithelial cells as acceptor cells found that the overexpression of Miro-1 in MSCs enhanced the mitochondrial transfer and rescue of epithelial injury, while Miro-1 knockdown led to a loss of this ability.…”

Section: Miro Gtpases Are Involved In Organelle Homeostasismentioning

confidence: 99%

Miro GTPases at the Crossroads of Cytoskeletal Dynamics and Mitochondrial Trafficking

Aspenström

2024

Cells

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Miro GTPases are key components in the machinery responsible for transporting mitochondria and peroxisomes along microtubules, and also play important roles in regulating calcium homeostasis and organizing contact sites between mitochondria and the endoplasmic reticulum. Moreover, Miro GTPases have been shown to interact with proteins that actively regulate cytoskeletal organization and dynamics, suggesting that these GTPases participate in organizing cytoskeletal functions and organelle transport. Derailed mitochondrial transport is associated with neuropathological conditions such as Parkinson’s and Alzheimer’s diseases. This review explores our recent understanding of the diverse roles of Miro GTPases under cytoskeletal control, both under normal conditions and during the course of human diseases such as neuropathological disorders.

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Targeting specific brain districts for advanced nanotherapies: A review from the perspective of precision nanomedicine

Sierri,

Patrucco,

Ferrario

et al. 2024

WIREs Nanomed Nanobiotechnol

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Numerous studies are focused on nanoparticle penetration into the brain functionalizing them with ligands useful to cross the blood–brain barrier. However, cell targeting is also crucial, given that cerebral pathologies frequently affect specific brain cells or areas. Functionalize nanoparticles with the most appropriate targeting elements, tailor their physical parameters, and consider the brain's complex anatomy are essential aspects for precise therapy and diagnosis. In this review, we addressed the state of the art on targeted nanoparticles for drug delivery in diseased brain regions, outlining progress, limitations, and ongoing challenges. We also provide a summary and overview of general design principles that can be applied to nanotherapies, considering the areas and cell types affected by the most common brain disorders. We then emphasize lingering uncertainties that hinder the translational possibilities of nanotherapies for clinical use. Finally, we offer suggestions for continuing preclinical investigations to enhance the overall effectiveness of precision nanomedicine in addressing neurological conditions.This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Tunneling nanotubes: The intercellular conduits contributing to cancer pathogenesis and its therapy

Cited by 10 publications

References 123 publications

Characteristics of the Colorectal Cancer Microenvironment—Role in Cancer Progression and Therapeutic Possibilities

Characteristics of the Colorectal Cancer Microenvironment—Role in Cancer Progression and Therapeutic Possibilities

Miro GTPases at the Crossroads of Cytoskeletal Dynamics and Mitochondrial Trafficking

Targeting specific brain districts for advanced nanotherapies: A review from the perspective of precision nanomedicine

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