TUR and Adjuvant Intravesical Chemotherapy in T1G3 Bladder Tumors: Recurrence, Progression and Survival in 137 Selected Patients Followed Up to 20 Years

Serretta, Vincenzo; Pavone, Carlo; Ingargiola, G. B.; Daricello, G; Allegro, Rosalinda; Pavone‐Macaluso, M.

doi:10.1016/j.eururo.2003.12.002

Cited by 32 publications

(6 citation statements)

References 26 publications

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“…The poor prognosis of T1G3 patients has been the subject of a number of recent publications. 16 – 18 We also observed that high-grade pT1 bladder tumor had shorter mean RFS and PFS than low-grade pT1 bladder tumor in the cohort. It has been reported that patients with high-risk NMIBC have poor prognosis due to the tumor progression and approximately 5% of pT1 bladder tumors have regional nodal metastasis at presentation.…”

Section: Discussionmentioning

confidence: 51%

Risk Factors Predictive of Recurrence and Progression for Patients Who Suffered Initial Recurrence After Transurethral Resection of Stage pT1 Bladder Tumor in Chinese Population

et al. 2016

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Bladder cancer is one of the most common malignancies worldwide and the stage pT1nonmuscle invasive bladder cancer (NMIBC) has a high probability of recurrence after initial diagnosis and treatment. However, risk factors predictive of repeated recurrence and progression of pT1 bladder tumors after primary relapse have not been uncovered. Thus, we conducted the retrospective study.A total of 418 patients who suffered initial recurrence after transurethral resection (TUR) of pT1 bladder tumor were selected for the analyses. Clinic information of the patients was retrieved from their medical records. Recurrence-free survival (RFS) and progression-free survival (PFS) were estimated using the Kaplan–Meier method. Univariate and multivariate analyses were performed using a Cox proportional hazards regression model. The probability of recurrence and progression by multivariate analyses was used as a surrogate marker to construct receiver operating curve (ROC).Results showed that variables including time to prior recurrence time, prior treatment, number of tumor, tumor size, tumor grade, and time of instillation after surgery were associated with the repeated recurrence of pT1 bladder tumor (P < 0.05). The variables including time to prior recurrence time, tumor size, tumor grade, carcinoma in situ (CIS), and time of instillation after surgery were associated with progression of pT1 bladder tumor (P < 0.05). In the present study, the multivariate model showed an area under ROC (AUC) value of 0.754 and 0.798 for tumor recurrence and progression, respectively, which was more effective in prediction than a single risk factor.In conclusion, we have identified several risk factors relevant to RFS and PFS for patients who have had a history of recurrence of pT1 bladder tumor after TUR. These predictive factors may help urologists to stratify patients into distinct risk groups of recurrence and progression, which probably contributes to the individualized treatment for patients.

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Section: Discussionmentioning

confidence: 51%

Risk Factors Predictive of Recurrence and Progression for Patients Who Suffered Initial Recurrence After Transurethral Resection of Stage pT1 Bladder Tumor in Chinese Population

et al. 2016

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“…However, the need for surgical excision of tumor mass is necessary when the neoplasia has not yet given metastasis at a distance, but it is not conservatively treatable to improve the patient’s prognosis. 4,5 In this clinical picture, it is therefore important to understand the outcomes of RC surgery in terms of complications and mortality in high-risk patients to ultimately assess the relationship between risk and benefit for the patient. Our study has the advantage of presenting a standardized assessment of patient comorbidity (via ACCI score) and postoperative complications (by Clavien–Dindo classification) and a recent observation period (2011–2016).…”

Section: Discussionmentioning

confidence: 99%

Postoperative complications and 90-day mortality in radical cystectomy in high-risk patients: A monocentric retrospective observational study

et al. 2018

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“…And another recent research also displayed that the number of tumors and degree of invasion were the most important prognostic factors for recurrence of NMIBC. [21] In addition, the poor prognosis and the high recurrence rate of T1 G3 patients has been mentioned in several publications [10,22,23] ; as shown in Table 2, our regression Cox analysis results revealed that the recurrence risk of T1 tumors was obviously higher than Ta tumors (HR: 3.132; P = .002), and G3 tumors also had a higher risk of recurrence compared with G1-G2 tumors (HR: 3.253; P < .001). What is more, immediate perfusion therapy could kill the residual cancer cells after surgery, to reduce implantation and recurrence of bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

Predicting recurrence of nonmuscle-invasive bladder cancer (Ta-T1)

Lü¹,

Song²,

Zhou³

et al. 2019

Medicine

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The aim of this study was to determine clinical recrudescent risk factors of 477 patients with newly discovered nonmuscle-invasive bladder cancer (NMIBC) (Ta-T1) in our hospital, and based on these factors, to establish a recurrence risk prediction model of each NMIBC patient. This study included 477 patients with newly discovered NMIBC (Ta-T1) from January 2012 to December 2016; all patients were treated surgically by transurethral resection of bladder tumor (TURBT). The outcomes of patients were with or without recurrence within 2 years. The nomograms were based on Cox regression analyses, and the calibration curves were founded to evaluate the agreements of the predicted probability with the actual observed probability. Of the 477 patients with NMIBC, 392 were males (82.2%) and 85 were females (17.8%), with median age 64 years. Recurrence was identified in 327 cases (68.6%). The results showed that old age, female sex, smoking history, large size of tumor, multifocal tumors, high grade, and high stage are risk factors for NMIBC recurrence, whereas no significant association was seen between tumor location and recurrence in our study. Based on the results of Cox regression analyses, several independent risk factors, including smoking history, tumor size, multifocal, immediate infusion therapy, T stage, and tumor grade, were used to establish a nomogram to calculate the recurrence probability of each NMIBC patient, and the calibration curve displayed that this nomogram had a great value of prediction. Old age, female sex, smoking history, large size of tumor, multifocal tumors, high grade, and high stage are risk factors for NMIBC recurrence, whereas immediate infusion therapy is a protective factor. And a nomogram was established as a prediction model to calculate the recurrence probability of NMIBC patients.

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TUR and Adjuvant Intravesical Chemotherapy in T1G3 Bladder Tumors: Recurrence, Progression and Survival in 137 Selected Patients Followed Up to 20 Years

Cited by 32 publications

References 26 publications

Risk Factors Predictive of Recurrence and Progression for Patients Who Suffered Initial Recurrence After Transurethral Resection of Stage pT1 Bladder Tumor in Chinese Population

Risk Factors Predictive of Recurrence and Progression for Patients Who Suffered Initial Recurrence After Transurethral Resection of Stage pT1 Bladder Tumor in Chinese Population

Postoperative complications and 90-day mortality in radical cystectomy in high-risk patients: A monocentric retrospective observational study

Predicting recurrence of nonmuscle-invasive bladder cancer (Ta-T1)

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