CAP1400 is an advanced large passive nuclear power technology under research and development, and related electromechanical equipment should be improved to guarantee the safety. The driving systems of main steam and feed water isolation valves are electromechanical equipment in nuclear power plants with nonlinear systems, which are not easy to be identified with traditional mathematical models. This article presents the design process of a novel driving system of the main steam isolation valve under the emergency quick-closing situation, which do not need the mathematical models. The novel driving system, which has a symmetrical and concise structure, is designed to include only two independent hydraulic output circuits, two independent hydraulic input circuits, and a nitrogen circuit for auxiliary driving. A cosimulation method, which takes advantage of AMESim, Adams, UG, and MATLAB, was proposed to establish the models of the main steam and feed water isolation valve and the driving system. Finally, co-simulations and experimental verifications of the emergency quick-closing situations, which include two hydraulic output circuits working together for quick closing and only one hydraulic output circuit for quick closing, were provided to confirm the performances and effectiveness of the proposed driving system and co-simulation method.