The “end of the vortex” (EoV) phenomenon, a flow instability that plays a crucial role in cyclone design and operation is studied in this article. In the experimental part of the study, tests were carried out to understand the origin and nature of the EoV and to study the effects of the flowrate through, and the length of, the cylindrical cyclone on the EoV. In the theoretical part, computational fluid dynamics (CFD) models, in agreement with the geometrical configurations and operating conditions used in the present and earlier experimental studies, were constructed and investigated. Three‐dimensional simulations were carried out using the large eddy turbulence model with the commercial CFD package Star‐CD. Bending of the vortex core to the wall of the vessel and its precessional motion, constituting the phenomenon of the EoV, was observed in the simulations in most geometries. The results are in a good agreement not only with the present experimental results but also with previous experimental observations. © 2011 American Institute of Chemical Engineers AIChE J, 2012