Designing effective AI models becomes a challenge when dealing with imbalanced/skewed class distributions in datasets. Addressing this, re-sampling techniques often come into play as potential solutions. In this investigation, we delve into the male fertility dataset, exploring fifteen re-sampling approaches to understand their impact on enhancing predictive model performance. The research employs conventional AI learners to gauge male fertility potential. Notably, five ensemble AI learners are studied, their performances compared, and their results are evaluated using four measurement indices. Through comprehensive comparative analysis, we identify substantial enhancement in model effectiveness. Our findings showcase that the LightGBM model with SMOTE-ENN re-sampling stands out, achieving an efficacy of 96.66% and an F1-score of 95.60% through 5-fold cross-validation. Interestingly, the CatBoost model, without re-sampling, exhibits strong performance, achieving an efficacy of 86.99% and an F1-score of 93.02%. Furthermore, we benchmark our approach against state-of-the-art methods in male fertility prediction, particularly highlighting the use of re-sampling techniques like SMOTE and ESLSMOTE. Consequently, our proposed model emerges as a robust and efficient computational framework, promising accurate male fertility prediction.