Turkish Society of Cardiology Consensus Paper onThe Rational Use of Cardiac Troponins in Daily Practice

Okyay, Kaan; Sadıç, Beste Özben; Şahinarslan, Asife; Durakoğlugil, Murtaza Emre; Karabay, Can Yücel; Eryüksel, Semiha; Gülbahar, Özlem; Tekin, Abdullah; Yı́ldı́rı́r, Aylin; Görenek, Bülent; Yavuzgil, Oğuz; Fak, Ali Serdar

doi:10.14744/anatoljcardiol.2019.42247

Cited by 3 publications

(2 citation statements)

References 134 publications

(156 reference statements)

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“…There are commercially developed antibody assays specific for cTnT and cTnI, but such assays have not been developed for cTnC due to lack of cardiac specificity 42 . It is important to note that there is misunderstanding that troponin elevation is secondary only to myocyte injury and necrosis But elevated cTn has been observed in many other clinical conditions 24,26,43,44,45 .…”

Section: Troponinmentioning

confidence: 99%

Coronary heart disease: historical perspective

Ralapanawa

2021

SL J. Med.

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Cardiovascular disease is the leading cause of mortality and morbidity worldwide. The 2011 annual report from the World Health Organization mentioned that, coronary heart disease and cerebro-vascular disease which were reported as the top two causes of mortality in 2004, are predicted to remain the major cause of death in the next 20 years. Coronary heart disease(CHD) and atherosclerosis were once thought to be a disease of modern humankind linked to modern lifestyle. However, researchers dispute this and has confirmed that atherosclerosis was common in preindustrial inhabitants too. Further, vascular system studies of mummies give substantial evidence of atherosclerosis as ancient human disease and clinical syndrome of angina pectoris existed in ancient Egypt. In 1768 the paper presented at the Royal College of Physicians in London on "Some account of a disorder of the breast" was an eye opener to medical professionals and later this excruciating "disorder of breast" was linked to the "hardening of the arteries''. In the past it was generally believed that MI virtually always resulted in death and identified in postmortem. In1878, the first case of coronary occlusion diagnosed during life was described. ECG was used to diagnose the condition in 1912 and the use of current 12-leads ECG became accepted practice since the 1950s. In addition to clinical evaluation and ECG, cardiac biomarkers play a pivotal role in diagnosis and management of acute coronary syndrome. Aspartate aminotransferase became the first biomarker used to diagnose and subsequently CK-MB isoenzyme, lactate dehydrogenase and myoglobin played very significant roles. Troponin is now considered the 'gold standard' biochemical test for the diagnosis. The definition, diagnosis, management and prognosis of coronary heart disease have changed over the decades with the development of medical science and knowledge. It is therefore interesting to appraise the historical aspect of evolution of CHD definitions and diagnosis. Moreover, clinicians should have updated knowledge on the evolution of definition, diagnosis, management and prognosis of this condition.

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Section: Troponinmentioning

confidence: 99%

Coronary heart disease: historical perspective

Ralapanawa

2021

SL J. Med.

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“…Hence, cases vith myocarditis should be followed up with supportive therapies and should be closely monitored for development of heart failure and arrhythmias. In progressive disease despite heart failure therapies and in patients with fulminant myocarditis which developt end organ failure, there are case reports on the usage of myocardial assist devices and extracorporeal membrane oxygenation (3)(4)(5)(6)(7)(8). There is no doubt that further multidisciplinary trials are needed regarding relationship between COVID-19 and myocarditis.…”

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confidence: 99%

COVID-19 and myocarditis/myocardial injury

Okyay

2021

Journal of Health Sciences and Medicine

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Myocarditis is defined as inflammation of the myocardium, and it presents with different clinical pictures, and its diagnosis has some difficulties. The prognosis of myocarditis is aetiology-dependent, and treatment is fundemantally supportive except for "endometrial biopsy proven" cases which requires spesific therapies including immunomodulators and intravenous immunoglobulins. SARS-CoV-2 affects cardiovascular systems directly or via indirectly mechanisms. COVID-19 infection increases the risks of myocardial injury, myocarditis, myocardial infarction, heart failure, venous thromboembolism and arrhythmias. The underlying mechanism of troponin elevation during COVID-19 infections is not exactly explained. In this review, the relationship between COVID-19 and myocardial involvement was discussed. Still, multidisciplinary trials are needed to explain this important situation.

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