Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

Sharifi‐Rad, Javad; Rayess, Youssef El; Rizk, Alain Abi; Sadaka, Carmen; Zgheib, Raviella; Zam, Wissam; Sestito, Simona; Rapposelli, Simona; Neffe‐Skocińska, Katarzyna; Zielińska, Dorota; Salehi, Bahare; Setzer, William N.; Dosoky, Noura S.; Taheri, Yasaman; Beyrouthy, Marc El; Martorell, Miquel; Ostrander, Elise Adrian; Suleria, Hafiz Ansar Rasul; Cho, William C.; Maroyi, Alfred; Martins, Natália

doi:10.3389/fphar.2020.01021

Cited by 534 publications

(356 citation statements)

References 202 publications

(308 reference statements)

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“…Curcumin, the main curcuminoid in Curcuma longa L. (turmeric), is a low-molecular-weight polyphenol, widely used in Ayurveda and Chinese medicine [ 87 ]. Turmeric type 97 (77% curcumin, 17% dexethoxycurcumin, and 3% bisdemethoxy curcumin) induced an increase in the level of transferrin receptor 1 (TfR1) and the induction of activated iron-regulatory proteins (IRPs), a decrease of the hepatic ferritin level and its H and L subunits [ 88 ].…”

Section: Natural Antioxidants In Iron Overload Treatmentmentioning

confidence: 99%

Natural Antioxidants in Anemia Treatment

Cotoraci

Ciceu

Sasu

2021

IJMS

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Anemia, characterized by a decrease of the hemoglobin level in the blood and a reduction in carrying capacity of oxygen, is a major public health problem which affects people of all ages. The methods used to treat anemia are blood transfusion and oral administration of iron-based supplements, but these treatments are associated with a number of side effects, such as nausea, vomiting, constipation, and stomach pain, which limit its long-term use. In addition, oral iron supplements are poorly absorbed in the intestinal tract, due to overexpression of hepcidin, a peptide hormone that plays a central role in iron homeostasis. In this review, we conducted an analysis of the literature on biologically active compounds and plant extracts used in the treatment of various types of anemia. The purpose of this review is to provide up-to-date information on the use of these compounds and plant extracts, in order to explore their therapeutic potential. The advantage of using them is that they are available from natural resources and can be used as main, alternative, or adjuvant therapies in many diseases, such as various types of anemia.

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Section: Natural Antioxidants In Iron Overload Treatmentmentioning

confidence: 99%

Natural Antioxidants in Anemia Treatment

Cotoraci

Ciceu

Sasu

2021

IJMS

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“…Modern medicine has shown that curcumin exhibits a broad range of biological and pharmacological activities, including antioxidant [ 20 ], anti-inflammatory [ 21 ], anti-tumor and chemosensitizing [ 22 ], hepatoprotective [ 23 ], lipid-modifying [ 24 ] and neuroprotective [ 25 ] effects and are suggested to improve mental illnesses due to its ability to modulate numerous signaling molecules [ 8 , 26 , 27 ]. Many studies show that it is safe to consume 8 g per day of curcumin [ 28 , 29 ]. Therefore, many curcumin based products are available such as tablets, capsules, and as an additive to various energy drinks [ 27 ].…”

Section: Curcuminmentioning

confidence: 99%

Curcumin and Its Derivatives as Theranostic Agents in Alzheimer’s Disease: The Implication of Nanotechnology

Shabbir

Tyagi

2020

IJMS

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Curcumin is a polyphenolic natural compound with diverse and attractive biological properties, which may prevent or ameliorate pathological processes underlying age-related cognitive decline, Alzheimer’s disease (AD), dementia, or mode disorders. AD is a chronic neurodegenerative disorder that is known as one of the rapidly growing diseases, especially in the elderly population. Moreover, being the eminent cause of dementia, posing problems for families, societies as well a severe burden on the economy. There are no effective drugs to cure AD. Although curcumin and its derivatives have shown properties that can be considered useful in inhibiting the hallmarks of AD, however, they have low bioavailability. Furthermore, to combat diagnostic and therapeutic limitations, various nanoformulations have also been recognized as theranostic agents that can also enhance the pharmacokinetic properties of curcumin and other bioactive compounds. Nanocarriers have shown beneficial properties to deliver curcumin and other nutritional compounds against the blood-brain barrier to efficiently distribute them in the brain. This review spotlights the role and effectiveness of curcumin and its derivatives in AD. Besides, the gut metabolism of curcumin and the effects of nanoparticles and their possible activity as diagnostic and therapeutic agents in AD also discussed.

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“…Important biotechnological applications of curcumin are widely used in the food industry where it is used as a spice or food additive, at a dose of 5–500 mg/kg, to ameliorate foodstuffs’ palatability and storage stability. The European Union has authorized the use of curcumin as food color with the name of CI 75300, Natural Yellow 3 or diferuloylmethane, and with the E100 code [ 20 ]. Curcumin is an efficient food preservative in its ability to suppress lipid peroxidation, suggesting a role as a possible natural preservative [ 21 ].…”

Section: Bioactivity and Health Benefits Of Curcuminmentioning

confidence: 99%

Novel Therapeutic Delivery of Nanocurcumin in Central Nervous System Related Disorders

et al. 2020

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Nutraceuticals represent complementary or alternative beneficial products to the expensive and high-tech therapeutic tools in modern medicine. Nowadays, their medical or health benefits in preventing or treating different types of diseases is widely accepted, due to fewer side effects than synthetic drugs, improved bioavailability and long half-life. Among herbal and natural compounds, curcumin is a very attractive herbal supplement considering its multipurpose properties. The potential effects of curcumin on glia cells and its therapeutic and protective properties in central nervous system (CNS)-related disorders is relevant. However, curcumin is unstable and easily degraded or metabolized into other forms posing limits to its clinical development. This is particularly important in brain pathologies determined blood brain barrier (BBB) obstacle. To enhance the stability and bioavailability of curcumin, many studies focused on the design and development of curcumin nanodelivery systems (nanoparticles, micelles, dendrimers, and diverse nanocarriers). These nanoconstructs can increase curcumin stability, solubility, in vivo uptake, bioactivity and safety. Recently, several studies have reported on a curcumin exosome-based delivery system, showing great therapeutical potential. The present work aims to review the current available data in improving bioactivity of curcumin in treatment or prevention of neurological disorders.

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Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

Cited by 534 publications

References 202 publications

Natural Antioxidants in Anemia Treatment

Natural Antioxidants in Anemia Treatment

Curcumin and Its Derivatives as Theranostic Agents in Alzheimer’s Disease: The Implication of Nanotechnology

Novel Therapeutic Delivery of Nanocurcumin in Central Nervous System Related Disorders

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