Turmeric based oral rinse “HTOR-091516” ameliorates experimental oral mucositis

Anturlikar, Suryakanth Dattatreya; Azeemuddin, Mohammed; Varma, Sandeep R.; Mallappa, Onkaramurthy; Niranjan, Dilip; Krishnaiah, Ashok Basti; Hegde, Shruthi Manjunath; Rafiq, M.; Paramesh, Rangesh

doi:10.4103/ayu.ayu_282_18

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…As a final remark, Anturlikar et al (2019) [24] in their in vitro and in vivo study with a combination of turmeric, Triphala, and honey (HTOR-091516) showed positive results such as low product toxicity, inflammation inhibition (TNF-α), and a protective effect against CT-induced OM.…”

Section: Honeymentioning

confidence: 99%

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A Narrative Review about Nutritional Management and Prevention of Oral Mucositis in Haematology and Oncology Cancer Patients Undergoing Antineoplastic Treatments

García-Gozalbo

Cabañas-Alite

2021

Nutrients

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Cancer is a prevalent disease worldwide, and treatments such as radiotherapy and chemotherapy sometimes lead to adverse events. Oral mucositis is one of the most disabling adverse events, and clinical guidelines do not take into account nutritional interventions. The primary endpoint was to gather the evidence about the efficacy of nutritional interventions in the prevention and/or treatment of antineoplastic-induced oral mucositis in oncological patients. A bibliographic review was carried out in the PubMed data base by combining MeSH terms with Boolean operators. Articles were selected based on inclusion and exclusion criteria; 50 final articles were found. Although further evidence is needed, glutamine, honey, and vitamins appear to be good therapeutic options. The rest of the compounds presented controversial or insufficient results, making it difficult to draw conclusions over their utilization as prevention or treatment options. Little evidence is reported about oral mucositis nutritional interventions in spite of them being attainable and affordable compounds. Scarce evidence is shown in paediatric patients compared with adults. Developing higher quality studies and combinations with the compounds researched is necessary for creating a stronger body of evidence.

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Section: Honeymentioning

confidence: 99%

“…Another compound studied as a possible prevention and/or treatment for OM was honey-having retrieved eight articles about it after preliminary research,. Out of those, seven articles were designed as research with different types of blinded clinical trials [36,43,49,52,55,56,59] and one of them was a laboratory study (in vitro and in vivo) [24].…”

Section: Honeymentioning

confidence: 99%

A Narrative Review about Nutritional Management and Prevention of Oral Mucositis in Haematology and Oncology Cancer Patients Undergoing Antineoplastic Treatments

García-Gozalbo

Cabañas-Alite

2021

Nutrients

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Polyphenolic extract from Artemisia selengensis Turcz ameliorates experimental oral mucositis

Yuan

Liu

et al. 2020

E3S Web Conf.

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Oral mucositis is a common and frequentoccurring disease and there is no effective treatment. In this study, we investigated the efficacy of polyphenolic extract from Artemisia selengensis Turcz (PPAST) in the prevention and treatment of oral mucositis. Cultured human gingival fibroblast cell HGF-1 was used as an in vitro experimental model to confirm the effect of PPAST inhibition of lipopolysaccharide(LPS) on cytotoxicity and its effect on the production of inflammatory cytokines. A rat model of oral ulcer was induced by acetic acid cauterization, and the curative effect of PPAST on oral ulcer was investigated from ulcer area and ulcer duration. PPAST significantly inhibited the toxic effect of LPS on HGF1 cells, improved the survival rate of HGF1 cells, and showed a concentration-dependent inhibition of TNF-α in HGF-1 cell. Treatment with PPAST reduced mucositis scores, promoted oral ulcer healing, and reduced plasma TNF-α levels in rats. Experimental data show that PPAST is safe and effective in the prevention and treatment of oral inflammatory diseases.

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Turmeric based oral rinse “HTOR-091516” ameliorates experimental oral mucositis

Cited by 2 publications

References 19 publications

A Narrative Review about Nutritional Management and Prevention of Oral Mucositis in Haematology and Oncology Cancer Patients Undergoing Antineoplastic Treatments

A Narrative Review about Nutritional Management and Prevention of Oral Mucositis in Haematology and Oncology Cancer Patients Undergoing Antineoplastic Treatments

Polyphenolic extract from Artemisia selengensis Turcz ameliorates experimental oral mucositis

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