Turmeric root extract supplementation improves pre-frontal cortex oxygenation and blood volume in older males and females: a randomised cross-over, placebo-controlled study

Rezende, Carla Ferreira; Oliveira, Gustavo Vieira de; Volino-Souza, Mônica; Castro, Patrícia; Murias, Juan M.; Álvares, Thiago Silveira

doi:10.1080/09637486.2021.1972411

Cited by 7 publications

(3 citation statements)

References 32 publications

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“…Turmeric and its formulations were reported to improve various conditions in healthy individuals, reducing their risk of developing chronic diseases. A diverse range of studies have reported the tolerability of turmeric and its formulations in humans. − For instance, a single dose of a 10 g turmeric root extract formulation in aged individuals improved oxygenation and cerebral blood flow, which are associated with improving brain activity . In another study, taking 1500 mg/day of BCM-95 (turmeric oil-based curcumin formulation) for 12 months stabilized cognitive function in older adults when compared to a placebo, recipients of which showed reduced cognitive function over the same period .…”

Section: Clinical Trials Of Turmeric and Curcuminmentioning

confidence: 99%

“…102−105 For instance, a single dose of a 10 g turmeric root extract formulation in aged individuals improved oxygenation and cerebral blood flow, which are associated with improving brain activity. 106 In another study, taking 1500 mg/ day of BCM-95 (turmeric oil-based curcumin formulation) for 12 months stabilized cognitive function in older adults when compared to a placebo, recipients of which showed reduced cognitive function over the same period. 107 In another study, consumption of 1500 mg/day of C. longa extract for 30 days reduced inflammation and muscle damage in marathon runners by increasing levels of the anti-inflammatory cytokine IL-10 and reducing the secretion of myoglobin.…”

Section: Clinical Trials Of Turmeric and Curcuminmentioning

confidence: 99%

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Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

Kunnumakkara

Hegde

Dey

et al. 2023

ACS Pharmacol. Transl. Sci.

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Turmeric (Curcuma longa) has been used for thousands of years for the prevention and treatment of various chronic diseases. Curcumin is just one of >200 ingredients in turmeric. Almost 7000 scientific papers on turmeric and almost 20,000 on curcumin have been published in PubMed. Scientific reports based on cell culture or animal studies are often not reproducible in humans. Therefore, human clinical trials are the best indicators for the prevention and treatment of a disease using a given agent/drug. Herein, we conducted an extensive literature survey on PubMed and Scopus following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The keywords "turmeric and clinical trials" and "curcumin and clinical trials" were considered for data mining. A total of 148 references were found to be relevant for the key term "turmeric and clinical trials", of which 70 were common in both PubMed and Scopus, 44 were unique to PubMed, and 34 were unique to Scopus. Similarly, for the search term "curcumin and clinical trials", 440 references were found to be relevant, of which 70 were unique to PubMed, 110 were unique to Scopus, and 260 were common to both databases. These studies show that the golden spice has enormous health and medicinal benefits for humans. This Review will extract and summarize the lessons learned about turmeric and curcumin in the prevention and treatment of chronic diseases based on clinical trials.

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Section: Clinical Trials Of Turmeric and Curcuminmentioning

confidence: 99%

Section: Clinical Trials Of Turmeric and Curcuminmentioning

confidence: 99%

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

Kunnumakkara

Hegde

Dey

et al. 2023

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

show abstract

“…Recently the effects of curcumin supplementation were also evaluated in older adults. In a double-blind, placebo-controlled, crossover design study (NCT04119752), curcumin was found to improve brain oxygenation and blood volume during exercise, highlighting the potential of this compound [ 229 ]. Additionally, a phase 2 clinical trial (NCT03085680) showed that curcumin improves cognitive and physical function in older adults.…”

Section: Polyphenols’ Regulation Of Ageing—a Clinical Perspectivementioning

confidence: 99%

The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks

Pereira

Santos

Fortunato

et al. 2023

IJMS

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Ageing is a complex process characterized mainly by a decline in the function of cells, tissues, and organs, resulting in an increased risk of mortality. This process involves several changes, described as hallmarks of ageing, which include genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, and altered intracellular communication. The determining role that environmental factors such as diet and lifestyle play on health, life expectancy, and susceptibility to diseases, including cancer and neurodegenerative diseases, is wellestablished. In view of the growing interest in the beneficial effects of phytochemicals in the prevention of chronic diseases, several studies have been conducted, and they strongly suggest that the intake of dietary polyphenols may bring numerous benefits due to their antioxidant and anti-inflammatory properties, and their intake has been associated with impaired ageing in humans. Polyphenol intake has been shown to be effective in ameliorating several age-related phenotypes, including oxidative stress, inflammatory processes, impaired proteostasis, and cellular senescence, among other features, which contribute to an increased risk of ageing-associated diseases. This review aims to address, in a general way, the main findings described in the literature about the benefits of polyphenols in each of the hallmarks of ageing, as well as the main regulatory mechanisms responsible for the observed antiageing effects.

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Effect of curcumin on endothelial function in humans and their proposed physiological mechanism: Insights in formulating curcumin products supplementation

Oliveira

Álvares

2022

PharmaNutrition

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Turmeric root extract supplementation improves pre-frontal cortex oxygenation and blood volume in older males and females: a randomised cross-over, placebo-controlled study

Cited by 7 publications

References 32 publications

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks

Effect of curcumin on endothelial function in humans and their proposed physiological mechanism: Insights in formulating curcumin products supplementation

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