Sub-Saharan Africa is highly vulnerable to climate change given its low capacities of resilience to the enormous challenges climate change will pose. Research aimed at evaluating changes in hydrological trends and methods of adaptation was conducted in the Niger Basin parts of Benin at the peak of the rainy season in the year 2012. Rainfall and river discharge were analyzed from 1950-2010 in order to generate patterns of changes in the region. Structured questionnaires were used to evaluate the perceptions of 14 farming communities on climate-related issues and their methods of adaptations. Mann-Kendall and Pettit trend analyses were conducted for rainfall and river discharge. The findings indicated that significant decreases characterized rainfall and river discharge in the period of study. Flash flood was considered the major challenge faced in the region according to more than 90% of crop, animal, and fish farmers. Aside from that, decrease in water availability was identified as an additional challenge. Irrigation, diversification, water treatment, drainage, small dams, and dikes were reported as the common adaptation mechanisms in the catchments. This study will help in designing sustainable adaptation mechanisms to abrupt changes in the hydrology of the region.