Turn-off fluorescence of nitrogen and sulfur carbon quantum dots as effective fluorescent probes for determination of imatinib. Application to biological fluids

Elhaleem, Shymaa M. Abd; Elsebaei, Fawzi; Shalan, Shereen; Belal, Fathalla

doi:10.1016/j.saa.2022.120954

Cited by 21 publications

(3 citation statements)

References 39 publications

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“…Generally, quenching of fluorescence has different mechanisms, including inner filter effect (IFE), dynamic quenching, and static quenching 55 . Since there was an overlapping between the excitation spectra of Ag-NPs and the UV–visible absorption spectra of ONZ, IFE could occur (Fig.…”

Section: Resultsmentioning

confidence: 99%

Green synthesis, characterization, and antimicrobial applications of silver nanoparticles as fluorescent nanoprobes for the spectrofluorimetric determination of ornidazole and miconazole

Magdy

Aboelkassim

El-Domany

et al. 2022

Sci Rep

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A green and simple method was proposed for the synthesis of silver nanoparticles (Ag-NPs) using Piper cubeba seed extract as a reducing agent for the first time. The prepared Ag-NPs were characterized using different spectroscopic and microscopic techniques. The obtained Ag-NPs showed an emission band at 320 nm when excited at 280 nm and exhibited strong green fluorescence under UV-light. The produced Ag-NPs were used as fluorescent nanosensors for the spectrofluorimetric determination of ornidazole (ONZ) and miconazole nitrate (MIZ) based on their quantitative quenching of Ag-NPs native fluorescence. The current study introduces the first spectrofluorimetric method for the determination of the studied drugs using Ag-NPs without the need for any pre-derivatization steps. Since the studied drugs don't exhibit native fluorescent properties, the importance of the proposed study is magnified. The proposed method displayed a linear relationship between the fluorescence quenching and the concentrations of the studied drugs over the range of 5.0–80.0 µM and 20.0–100.0 µM with limits of detection (LOD) of 0.35 µM and 1.43 µM for ONZ and MIZ, respectively. The proposed method was applied for the determination of ONZ and MIZ in different dosage forms and human plasma samples with high % recoveries and low % RSD values. The developed method was validated according to ICH guidelines. Moreover, the synthesized Ag-NPs demonstrated significant antimicrobial activities against three different bacterial strains and one candida species. Therefore, the proposed method may hold potential applications in the antimicrobial therapy and related mechanism research.

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Section: Resultsmentioning

confidence: 99%

Green synthesis, characterization, and antimicrobial applications of silver nanoparticles as fluorescent nanoprobes for the spectrofluorimetric determination of ornidazole and miconazole

Magdy

Aboelkassim

El-Domany

et al. 2022

Sci Rep

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“…For fluorescence methods, the unique chemical, optical and electrochemical characteristics of nanomaterials including carbon quantum dots and gold nanoclusters have attracted great attentions for various applications in biosensing, catalysis, fluorescence detection and cell imaging. [21][22][23][24][25][26][27][28] Compared with carbon quantum dots, gold nanoclusters (Au NCs) possess many excellent properties such as good water soluble, large stokes shift, low toxicity, excellent photostability and biocompatibility, and they have been widely used in many fields. [29][30][31][32][33][34][35][36][37][38] Many methods have been used to synthesize Au NCs such as etching method, [39] reversible phase transfer method, [40] microwave-assisted method, [41] sonochemical method, [42] photoreduction, [43] dynamic control method, [44] electrochemical method, [45] template-assisted method.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoclusters as a Fluorescent Probe for the Sensitive Determination of Morin and Sensing of Temperature

et al. 2022

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The fluorescence detection has attracted extensive attentions because of its selective and sensitive determining characteristics for a series of analytes. In this detection system, a fluorescence method was first developed for the analysis of morin (MR) based on gold nanoclusters, which was prepared using tryptophan as the stabilizer and reducing agent. The assynthesized gold nanoclusters (Trp-Au NCs) showed maximum excitation wavelength and emission wavelength at 368 and 449 nm, respectively. When MR was added, the fluorescence intensity at 449 nm was significantly quenched, which might be attributed to the inner filter effect (IFE) and static quenching. The ln(F 0 /F) value of Trp-Au NCs displayed excellent linearity for sensing MR in the range of 0.5-90 μM (R 2 = 0.9958) with a lower detection limit of 0.063 μM. This proposed sensor could be used for the sensing of temperature. Moreover, this fluorescence detecting strategy was successfully used in real samples, which indicated its great potential value for MR sensing in actual samples.

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“…The introduction of heteroatoms, such as boron (B), sulfur (S), nitrogen (N), and phosphorous (P) into the overall structure-of-CQDs, with or without surface changes, is known as doping. Doping CQDs increases their quantum yields and improves their fluorescence qualities, allowing them to be used in various applications [45][46][47][48][49][50][51] . Because nitrogen has an atomic radius similar to that of carbon, and sulfur and carbon have similar electronegativity, SN-CQDs represent one of the most important doped-CQDs 52 .…”

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confidence: 99%

Sulfur and nitrogen co-doped carbon quantum dots as fluorescent probes for the determination of some pharmaceutically-important nitro compounds

Magdy

Ebrahim

Belal

et al. 2023

Sci Rep

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In this study, highly fluorescent sulfur and nitrogen co-doped carbon quantum dots (SN-CQDs) were synthesized by a simple one-pot hydrothermal method using thiosemicarbazide and citric acid as starting materials. Various spectroscopic and microscopic techniques were applied to characterize the prepared SN-CQDs. The synthesized SN-CQDs’ maximum fluorescence emission was obtained at 430 nm after excitation at 360 nm. Rifampicin (RFP), tinidazole (TNZ), ornidazole (ONZ), and metronidazole (MNZ) all quantitatively and selectively quenched the SN-CQDs’ native fluorescence, which was the base-for their-spectrofluorimetric estimation without the need for any tedious pre-treatment steps or high-cost instrumentation. SN-CQDs demonstrated a “turn-off” fluorescence response to RFP, TNZ, ONZ, and MNZ over the ranges of 1.0–30.0, 10.0–200.0, 6.0–200.0, and 5.0–100.0 μM with detection limits of 0.31, 1.76, 0.57, and 0.75 μM and quantitation limits of 0.93, 5.32, 1.74, and 2.28 μM respectively. The suggested method was successfully used to determine the investigated drugs in their commercial dosage forms. The method was further extended to their determination in spiked human plasma samples, with satisfactory mean % recoveries (99.44–100.29) and low % RSD values (< 4.52). The mechanism of fluorescence quenching was studied and discussed. The suggested method was validated in accordance with ICH recommendations.

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Turn-off fluorescence of nitrogen and sulfur carbon quantum dots as effective fluorescent probes for determination of imatinib. Application to biological fluids

Cited by 21 publications

References 39 publications

Green synthesis, characterization, and antimicrobial applications of silver nanoparticles as fluorescent nanoprobes for the spectrofluorimetric determination of ornidazole and miconazole

Green synthesis, characterization, and antimicrobial applications of silver nanoparticles as fluorescent nanoprobes for the spectrofluorimetric determination of ornidazole and miconazole

Gold Nanoclusters as a Fluorescent Probe for the Sensitive Determination of Morin and Sensing of Temperature

Sulfur and nitrogen co-doped carbon quantum dots as fluorescent probes for the determination of some pharmaceutically-important nitro compounds

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