Turn-off near-infrared fluorescent probe for free bilirubin detection constructed by enhanced excimer emission

Qi, Shuang; He, Xiongfei; Zhang, Shensong; Xu, Ping; Su, Min; Dong, Bin; Song, Bo

doi:10.1016/j.aca.2022.340657

Cited by 14 publications

(2 citation statements)

References 67 publications

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“…Bovine serum albumin (BSA), which exhibits high structural homology with human serum albumin and is more readily available, has been extensively studied as a model protein in various fields. − Over the years, numerous methods, including electrochemical impedance spectroscopy, near-infrared diffuse reflectance spectroscopy, capillary electrophoresis, and UV spectroscopy, have been developed for BSA detection. Although these methods offer high selectivity and sensitivity, they suffer from drawbacks such as inaccurate measurement results, complex operational procedures, poor reproducibility, and time-consuming measurements. − In contrast, the fluorescence probe method, characterized by its ease of use, accuracy, and excellent reproducibility, has emerged as an ideal detection method, gaining increasing attention from analysts. − …”

Section: Introductionmentioning

confidence: 99%

Turn-On Fluorescent Probe for BSA Detection Constructed by Supramolecular Assembly

Mao,

Zhang,

Zhang

et al. 2024

Langmuir

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The fluorescent probe method has attracted significant research attention due to its high sensitivity and reproducibility in detecting bovine serum albumin (BSA). In this study, we constructed a fluorescent probe for BSA detection by assembling an amphiphilic organic fluorescent molecule, termed 2-(2'-hydroxyphenyl) benzothiazole (HBT-11), with BSA. In an aqueous solution, HBT-11 exhibited a weak fluorescence emission at 501 nm. However, the addition of BSA substantially enhanced the fluorescence emission at 501 nm, indicating that the assembly was driven by electrostatic interactions between HBT-11 and BSA. HBT-11, serving as a fluorescent probe for BSA detection, demonstrated a limit of detection (LOD) as low as 3.92 nmol L −1 , excellent photostability, high selectivity, and robust anti-interference capability. Notably, we successfully applied HBT-11 for detecting BSA in fetal bovine serum and selectively imaging BSA in HeLa cells.

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Section: Introductionmentioning

confidence: 99%

Turn-On Fluorescent Probe for BSA Detection Constructed by Supramolecular Assembly

Mao,

Zhang,

Zhang

et al. 2024

Langmuir

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“…Several fluorescence methods, using carbon dots, [6][7][8] metal nanoclusters, 9 MOFs, 10,11 organic molecules, [12][13][14][15][16][17] have been developed for the detection of bilirubin. However, these are limited due to the "Turn OFF" signal and poor sensitivity and dependence on a spiking method for clinical detection.…”

Section: Introductionmentioning

confidence: 99%

Efficient detection of bilirubin in human serum through a displacement approach

Singla,

Ahmad,

Mahajan

et al. 2023

Sens. Diagn.

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Biosynthesis of copper nanoclusters for fluorescence detection of bilirubin in biofluids

Molatrati,

Borse,

Ghosh

et al. 2024

Luminescence

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Copper nanoclusters (Cu NCs) have shown significant attention in sensing of molecular and ionic species. In this work, a single‐step biosynthetic approach was introduced for the preparation of fluorescent Cu NCs using Holarrhena pubescens (H. pubescens) leaves extract as a template. The synthesized H. pubescens–Cu NCs act as a nanomolecular probe for the detection of bilirubin in biofluids. The synthesized H. pubescens–Cu NCs displayed highest fluorescence intensity at 454 nm, when excited at 330 nm. Importantly, selective detection of bilirubin was obtained by introducing H. pubescens–Cu NCs as a simple molecular probe. The interaction of bilirubin and H. pubescens–Cu NCs resulted in a remarkable decrease in the emission peak intensity. The developed H. pubescens–Cu NCs‐based bilirubin molecular probe has a wide linear range of 0.5–20.00 μM with the limit of detection of 30.54 nM for bilirubin. The promising application of H. pubescens–Cu NCs‐based molecular probe was assessed by assaying bilirubin in spiked biofluids.

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Turn-off near-infrared fluorescent probe for free bilirubin detection constructed by enhanced excimer emission

Cited by 14 publications

References 67 publications

Turn-On Fluorescent Probe for BSA Detection Constructed by Supramolecular Assembly

Turn-On Fluorescent Probe for BSA Detection Constructed by Supramolecular Assembly

Efficient detection of bilirubin in human serum through a displacement approach

Biosynthesis of copper nanoclusters for fluorescence detection of bilirubin in biofluids

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