Turn-on fluorescence detection of carbon monoxide in plant tissues based on Cu<sup>2+</sup> modulated polydihydroxyphenylalanine nanosensors

Mu, Xiqiong; Wang, Yinquan; Xu, Jian; Zeng, Fankui

doi:10.1039/d4ay01034e

Anal. Methods

2024

DOI: 10.1039/d4ay01034e

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Turn-on fluorescence detection of carbon monoxide in plant tissues based on Cu²⁺ modulated polydihydroxyphenylalanine nanosensors

Xiqiong Mu,

Yinquan Wang,

Jian Xu

et al.

Abstract: As an important signaling molecule, carbon monoxide (CO) plays an important role in plant growth and development including affecting stomatal movement, stress response and root development. Thus, it is necessary...

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A Tale of Two Cities in Fluorescent Sensing of Carbon Monoxide: Probes That Detect CO and Those That Detect Only Chemically Reactive CO Donors (CORMs), but Not CO

Liu,

Yang,

Wang

2024

J. Org. Chem.

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Carbon monoxide (CO) is endogenously produced with a range of pharmacological activities. Sensitive and selective detection of CO is critical to studying its biology. Since the first report of a CO fluorescent probe in 2012, more than 100 papers on this topic have appeared. Noteworthy in such work is the widespread use of two commercially available ruthenium−carbonyl complexes (CORM-2 and CORM-3) as CO surrogates. Unfortunately, these two CORMs are chemically very reactive and preferentially release CO 2 but not CO, unless in the presence of a nucleophile. As a result, there are "two tales" of the reported CO probes: those that detect CO and those that detect only the CORM used but not CO. In addition, because of their lack of reliable CO production and fast degradation in an aqueous solution, there is the question of what "detecting CORM-2 or CORM-3" really means in the context of CO research. Additionally, for applying fluorescent CO probes in detecting low levels (often nanomolar) of CO in vivo, fast reaction kinetics is a prerequisite for meaningful results. In this Perspective, we discuss in detail these issues with the understanding of the evolutionary nature of scientific discoveries and the aim of preventing further confusion.

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A Tale of Two Cities in Fluorescent Sensing of Carbon Monoxide: Probes That Detect CO and Those That Detect Only Chemically Reactive CO Donors (CORMs), but Not CO

Liu,

Yang,

Wang

2024

J. Org. Chem.

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show abstract

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Turn-on fluorescence detection of carbon monoxide in plant tissues based on Cu²⁺ modulated polydihydroxyphenylalanine nanosensors

Abstract: As an important signaling molecule, carbon monoxide (CO) plays an important role in plant growth and development including affecting stomatal movement, stress response and root development. Thus, it is necessary...

Cited by 1 publication

References 50 publications

A Tale of Two Cities in Fluorescent Sensing of Carbon Monoxide: Probes That Detect CO and Those That Detect Only Chemically Reactive CO Donors (CORMs), but Not CO

A Tale of Two Cities in Fluorescent Sensing of Carbon Monoxide: Probes That Detect CO and Those That Detect Only Chemically Reactive CO Donors (CORMs), but Not CO

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Turn-on fluorescence detection of carbon monoxide in plant tissues based on Cu2+ modulated polydihydroxyphenylalanine nanosensors

Abstract: As an important signaling molecule, carbon monoxide (CO) plays an important role in plant growth and development including affecting stomatal movement, stress response and root development. Thus, it is necessary...

Cited by 1 publication

References 50 publications

A Tale of Two Cities in Fluorescent Sensing of Carbon Monoxide: Probes That Detect CO and Those That Detect Only Chemically Reactive CO Donors (CORMs), but Not CO

A Tale of Two Cities in Fluorescent Sensing of Carbon Monoxide: Probes That Detect CO and Those That Detect Only Chemically Reactive CO Donors (CORMs), but Not CO

Contact Info

Product

Resources

About

Turn-on fluorescence detection of carbon monoxide in plant tissues based on Cu²⁺ modulated polydihydroxyphenylalanine nanosensors