Turn-on fluorescent chemosensor for Zn(ii) via ring opening of rhodamine spirolactam and their live cell imaging

Abstract

A new rhodamine based selective and sensitive turn-on fluorescent Zn(2+)chemosensor has been developed. A prominent fluorescence enhancement was found in the presence of Zn(2+), which was accompanied by changes in the absorption spectrum. The new sensor showed 'naked-eye' detection of Zn(2+) ions: a color change of the solution from colorless to pink. Furthermore, by means of confocal laser scanning microscopy experiments, it has been demonstrated that it can be used as a fluorescent probe for monitoring Zn(2+) in living cells.

Two Schiff-base fluorescent sensors for selective sensing of aluminum (III): Experimental and computational studies

“…In the past few years, fluorescent probes have currently attracted significant interest because of its high sensitivity, selectivity, rapidity and easy operational procedure, therefore, the design and synthesis of fluorescent chemosensors remains an important endeavor in chemistry [8][9][10][11][12][13][14][15][16][17][18][19].…”

A novel piperazine-bis(rhodamine-B)-based chemosensor for highly sensitive and selective naked-eye detection of Cu2+ and its application as an INHIBIT logic device

“…The rhodamine derivatives are non-fluorescent and colorless, whereas when they coordinate with some metal ions, the ring-opening of the corresponding spirolactam gives off a strong fluorescent emission and pink color [36][37][38][39]. Based on this mechanism, some rhodamine-based spirolactam probes have been reported for the recognition of different metal ions [35,[40][41][42].…”

A water-soluble pH fluorescence probe based on quaternary ammonium salt for bioanalytical applications

“…Currently, lots of novel fluorescence probes were reported based on the philosophy that the combination between the proton and the lone pair electrons within nitrogen, which could change the optical properties of fluorescent probes [33][34][35][36][37][38], besides that, pH-induced ring-opening reaction of the rhodamine is broadly used by varying the conjugated system [39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54]. Even though lots of rhodamine-based fluorescence probes have been widely applied in both solution and biosensing systems to discriminate the analytes from other biological abundant species so far, poor solubility of these probes in biological environments might result in decreased detection sensitivity, or even lose the response signal, which is a research bottleneck as regards progress in some areas of cell biology or medicine [55][56][57][58].…”