2019
DOI: 10.1002/chem.201903631
|View full text |Cite
|
Sign up to set email alerts
|

Turning DNA Binding Motifs into a Material for Flow Cells

Abstract: Nanoscale assemblies of DNA strands are readily designed and can be generated in a wide range of shapes and sizes. Turning them into solids that bind biomolecules reversibly, so that they can act as active material in flow cells, is a challenge. Among the biomolecular ligands, cofactors are of particular interest because they are often the most expensive reagents of biochemical transformations, for which controlled release and recycling are desirable. We have recently described DNA triplex motifs that bind ade… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(2 citation statements)
references
References 40 publications
0
2
0
Order By: Relevance
“…It will benefit aptamer-based molecular devices, improving their diagnostic and therapeutic efficacy. Such design, along with other related studies, is not only a test on our current understanding/knowledge of the basic principles that determine DNA structures but also, we hope, will stimulate exploration of rational designing functional DNA molecules in general and provide insights to improve the widely used SELEX method. , …”
Section: Discussionmentioning
confidence: 99%
“…It will benefit aptamer-based molecular devices, improving their diagnostic and therapeutic efficacy. Such design, along with other related studies, is not only a test on our current understanding/knowledge of the basic principles that determine DNA structures but also, we hope, will stimulate exploration of rational designing functional DNA molecules in general and provide insights to improve the widely used SELEX method. , …”
Section: Discussionmentioning
confidence: 99%
“…Reinforcing the gap with linkers can improve binding, and the binding capacity can be optimized by introducing several binding sites per triplex . Rationally designed triplex binding motifs can be turned into functional materials operating in macroscopic devices by precipitating them with protamines . Thus far, however, the binding properties of DNA and RNA triplexes have not been used for spin labeling.…”
Section: Introductionmentioning
confidence: 99%