Turning Meat, Poultry, Eggs, and Dairy Products Into Nutraceuticals, Part Two: The Literature of Animal Nutrition Aimed at Increasing Conjugated Linoleic Acid Levels in Beef, Lamb, Goat, Pork, and Broilers as a Part of a Value-Added Functional Foods Strategy

Stankus, Tony

doi:10.1080/10496500802690544

Cited by 1 publication

(1 citation statement)

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“…Among them, a large body of evidence indicated the prominent role of n -3 PUFA as protective lipid mediators in the context of inflammatory, metabolic, neurodegenerative, and neoplastic diseases [33,34]. This evidence has drawn the attention of clinicians and animal scientists to the possibility of turning animal-derived products into functional foods providing health benefits to consumers [35–37]. Studies have reported that the content of n -3 PUFA in swine muscle can be increased adding oilseed ingredients to the feed [38,39], and the addition of antioxidant compounds such as vitamin E and polyphenols can help to avoid lipid oxidation [38,40].…”

Section: Discussionmentioning

confidence: 99%

Functional analysis finds differences on the muscle transcriptome of pigs fed an n-3 PUFA-enriched diet with or without antioxidant supplementations

Vitali¹,

Sirri²,

Zappaterra³

et al. 2019

PLoS ONE

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Supplementing pig diets with n -3 polyunsaturated fatty acids ( n- 3 PUFA) may produce meat products with an increased n -3 fatty acid content, and the combined antioxidants addition could prevent lipid oxidation in the feed. However, to date, the effects of these bioactive compounds at the molecular level in porcine skeletal muscle are mostly unknown. This study aimed to analyse changes in the Longissimus thoracis transcriptome of 35 pigs fed three diets supplemented with: linseed (L); linseed, vitamin E and Selenium (LES) or linseed and plant-derived polyphenols (LPE). Pigs were reared from 80.8 ± 5.6 kg to 151.8 ± 9.9 kg. After slaughter, RNA-Seq was performed and 1182 differentially expressed genes (DEGs) were submitted to functional analysis. The L vs LES comparison did not show differences, while L vs LPE showed 1102 DEGs and LES vs LPE 80 DEGs. LPE compared to the other groups showed the highest number of up-regulated genes involved in preserving muscle metabolism and structure. Results enlighten that the combined supplementation of bioactive lipids ( n- 3 PUFA from linseed) with plant extracts as a source of polyphenols increases, compared to the only addition of linseed, the expression of genes involved in mRNA metabolic processes and transcriptional regulation, glucose uptake and, finally, in supporting muscle development and physiology. These results improve the knowledge of the biological effect of bioactive compounds in Longissimus thoracis muscle, and sustain the growing interest over their use in pig production.

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