Turning the Pathogenesis of Acute Peptic Esophagitis Inside Out

Kahrilas, Peter J.

doi:10.1001/jama.2016.5827

Cited by 6 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study supports this expectation given the high importance rankings of GERD from the random forest in this study: GERD for the years 2012, 2014, 2010, 2013, 2007, 2009 and 2006 ranked within the top ten. GERD is reported to cause cytokine-triggered inflammation, 16 17 18 which is expected to cause uterine contraction and preterm birth. 19 20 21 22 As a matter of fact, GERD symptoms such as nausea and vomiting are quite general but usually ignored among pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Association of Gastroesophageal Reflux Disease with Preterm Birth: Machine Learning Analysis

Lee

Kim

et al. 2021

J Korean Med Sci

View full text Add to dashboard Cite

Background This study used machine learning and population data for testing the associations of preterm birth with gastroesophageal reflux disease (GERD) and periodontitis. Methods Retrospective cohort data came from Korea National Health Insurance Service claims data for all women who aged 25–40 years and gave births for the first time as singleton pregnancy during 2015–2017 (405,586 women). The dependent variable was preterm birth during 2015–2017 and the independent variables were GERD (coded as no vs. yes) for each of the years 2002–2014, periodontitis (coded as no vs. yes) for each of the years 2002–2014, age (year) in 2014, socioeconomic status in 2014 measured by an insurance fee, and region (city) (coded as no vs. yes) in 2014. Random forest variable importance was adopted for finding main predictors of preterm birth and testing its associations with GERD and periodontitis. Results Based on random forest variable importance, main predictors of preterm birth during 2015–2017 were socioeconomic status in 2014, age in 2014, GERD for the years 2012, 2014, 2010, 2013, 2007 and 2009, region (city) in 2014 and GERD for the year 2006. The importance rankings of periodontitis were relatively low. Conclusion Preterm birth has a stronger association with GERD than with periodontitis. For the prevention of preterm birth, preventive measures for GERD would be essential together with the improvement of socioeconomic status for pregnant women. Especially, it would be vital to promote active counseling for general GERD symptoms (neglected by pregnant women).

show abstract

Section: Discussionmentioning

confidence: 99%

Association of Gastroesophageal Reflux Disease with Preterm Birth: Machine Learning Analysis

Lee

Kim

et al. 2021

J Korean Med Sci

View full text Add to dashboard Cite

show abstract

“…Later it was found that stopping proton-pump inhibitors in patients with severe RE was associated with esophageal inflammation without loss of surface cells. [ 27 , 28 ] It was demonstrated that esophageal epithelial cells secreted interleukin-8, interleukin-1β, and other potent proinflammatory cytokines when exposed to acidic bile salts. [ 26 ] Additionally, it was reported that inflammatory pathways are not only involved in the initiation and maintenance of AF, but also contribute to both electrical and structural atrial remodeling and thrombogenesis in patients with AF.…”

Section: Discussionmentioning

confidence: 99%

“…Souza et al [26] developed a RE rat model after esophagoduodenostomy and found the inflammation did not start in the mucosa, but deep in the epithelium by histological study. Later it was found that stopping proton-pump inhibitors in patients with severe RE was associated with esophageal inflammation without loss of surface cells [27,28] . It was demonstrated that esophageal epithelial cells secreted interleukin-8, interleukin-1β, and other potent proinflammatory cytokines when exposed to acidic bile salts [26] .…”

Section: Discussionmentioning

confidence: 99%

Reflux esophagitis is associated with higher risks of acute stroke and transient ischemic attacks in patients hospitalized with atrial fibrillation

et al. 2021

View full text Add to dashboard Cite

Reflux esophagitis (RE) is a subset of gastroesophageal reflux disease (GERD) with endoscopic evidence of esophageal inflammation, which has been linked to an increased incidence of atrial fibrillation (AF). However, data on the effect of RE on patient outcomes is limited. We sought to examine the potential association of RE with outcomes of patients with AF in a nationwide study. The National Inpatient Sample (NIS) database was queried to identify hospitalized adult patients with AF and RE between 2010 and 2014. Primary outcomes included inpatient mortality, length of stay (LOS), and total hospital charges. AF related complications such as acute stroke, transient ischemic attack (TIA) and acute heart failure were assessed as secondary outcomes. Propensity score matching and multivariate regression analysis were used. Six lakh sixty seven thousands five hundred twenty patients were admitted for primary diagnosis of AF out of which 5396 had a secondary diagnosis of RE. In the AF with RE cohort, the average age was 73.6 years, 41.5% were male, and 79.9% were Caucasian. There was a greater prevalence of concomitant dyslipidemia, chronic liver disease and chronic pulmonary disease ( P < .01) when compared to the AF without RE cohort. Patients with AF and RE also had higher incidence of acute strokes and TIAs ( P < .05), longer LOS ( P < .001), and higher hospital charges ( P < .05) with no difference in acute heart failure ( P = .08), hospital mortality ( P = .12), or CHA 2 DS 2 -VASc score ( P = .67). In hospitalized patients with AF, RE was associated with a higher rate of acute stroke and TIAs, longer LOS, and greater hospital charges.

show abstract

“…Souza et al [26] developed a RE rat model after esophagoduodenostomy and found the inflammation did not start in the mucosa, but deep in the epithelium by histological study. Later it was found that stopping proton-pump inhibitors in patients with severe RE was associated with esophageal inflammation without loss of surface cells [27,28]. It was demonstrated that esophageal epithelial cells secreted interleukin (IL)-8, IL-1β, and other potent proinflammatory cytokines when exposed to acidic bile salts [26].…”

Section: Discussionmentioning

confidence: 99%

Reflux Esophagitis is Associated with Higher Risks of Acute Stroke and Transient Ischemic Attacks in Patients Hospitalized with Atrial Fibrillation: A Nationwide Inpatient Sample Analysis

Jiang

Damiris

Suero-Abreu

et al. 2020

Preprint

View full text Add to dashboard Cite

Objectives: Reflux esophagitis (RE) is a subset of gastroesophageal reflux disease (GERD) with endoscopic evidence of esophageal inflammation, which has been linked to an increased incidence of atrial fibrillation (AF). However, data on the effect of RE on patient outcomes is limited. We sought to examine the potential association of RE with outcomes of patients with AF in a nationwide study. Methods: The National Inpatient Sample (NIS) database was queried to identify hospitalized adult patients with AF and RE between 2010 and 2014. Primary outcomes included inpatient mortality, length of stay (LOS), and total hospital charges. AF related complications such as acute stroke, transient ischemic attack (TIA) and acute heart failure were assessed as secondary outcomes. Propensity score matching and multivariate regression analysis were used. Results: 667,520 patients were admitted for primary diagnosis of AF out of which 5,396 had a secondary diagnosis of RE. In the AF with RE cohort, the average age was 73.6 years, 41.5% were male, and 79.9% were Caucasian. There was a greater prevalence of concomitant dyslipidemia, chronic liver disease and chronic pulmonary disease (p <0.01) when compared to the AF without RE cohort. Patients with AF and RE also had higher incidence of acute strokes and TIAs (p<0.05), longer LOS (p<0.001), and higher hospital charges (p<0.05) with no difference in acute heart failure (p=0.08), hospital mortality (p=0.12), or CHA2DS2-VAS score (p=0.67). Conclusion: In hospitalized patients with AF, RE was associated with a higher rate of acute stroke and TIA, longer LOS, and greater hospital charges.

show abstract

Turning the Pathogenesis of Acute Peptic Esophagitis Inside Out

Cited by 6 publications

References 13 publications

Association of Gastroesophageal Reflux Disease with Preterm Birth: Machine Learning Analysis

Association of Gastroesophageal Reflux Disease with Preterm Birth: Machine Learning Analysis

Reflux esophagitis is associated with higher risks of acute stroke and transient ischemic attacks in patients hospitalized with atrial fibrillation

Reflux Esophagitis is Associated with Higher Risks of Acute Stroke and Transient Ischemic Attacks in Patients Hospitalized with Atrial Fibrillation: A Nationwide Inpatient Sample Analysis

Contact Info

Product

Resources

About