Turning the Spotlight on Apathy: Identification and Treatment in Schizophrenia Spectrum Disorders

Lyngstad, Siv Hege; Lyne, John; Ihler, Henrik Myhre; Meer, Lisette van der; Færden, Ann; Melle, Ingrid

doi:10.1093/schbul/sbad070

Schizophrenia Bulletin

2023

DOI: 10.1093/schbul/sbad070

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Turning the Spotlight on Apathy: Identification and Treatment in Schizophrenia Spectrum Disorders

Siv Hege Lyngstad

John Lyne

Henrik Myhre Ihler

et al.

Abstract: Among negative symptoms, apathy is central to the impairments in real-life functioning in schizophrenia spectrum disorders (SSD). Thus, optimizing treatment for apathy appears key to improve outcomes. In treatment research, however, negative symptoms are typically studied as a unifactorial construct. We, therefore, aim to shed necessary light on the status of apathy identification and treatment in SSD.

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2024

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Towards a Non-pharmacological Intervention on Apathy in Korsakoff’s Syndrome: A Systematic Narrative Review Across Different Clinical Conditions

van Dorst,

Rensen,

Nijsten

et al. 2024

NDT

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Apathy is a quantitative reduction of goal-directed activity, which can be observed in relation to behavior, cognition, emotions and social interaction. It is an invalidating behavioral symptom that is frequently present across different psychiatric conditions and neurocognitive disorders including Korsakoff’s Syndrome (KS). In fact, apathy is one of the most severe behavioral symptoms of KS and has a major impact on the lives of patients and their relatives and other informal caregivers. However, guidelines for the treatment of apathy in KS are currently not available. This systematic narrative review provides a transdiagnostic overview of the effectiveness of different types of non-pharmacological interventions on apathy across different study populations that at symptom-level share characteristics with KS. This evidence may inform the development of an intervention targeting apathy in KS. The included study populations are dementia (due to Alzheimer’s disease, or vascular dementia), Parkinson’s disease, schizophrenia and traumatic brain injury. Through a stepped selection approach and with regard to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, 22 systematic reviews and 32 empirical articles on the non-pharmacological treatment of apathy were identified. The results show a variety of effective non-pharmacological interventions on apathy. In conditions with severe cognitive impairments, successful interventions did not rely on intrinsic motivation, self-monitoring, or illness insight of the patients, but depend on external stimulation and behavioral activation. Since apathy is a multidimensional construct, identification of the extent and type of apathetic behavior before starting an intervention is highly recommended. Furthermore, it is important to adjust the treatment to the patients’ personal interests and needs and embedded in daily care. Trial registration CRD42022298464 (PROSPERO).

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Towards a Non-pharmacological Intervention on Apathy in Korsakoff’s Syndrome: A Systematic Narrative Review Across Different Clinical Conditions

van Dorst,

Rensen,

Nijsten

et al. 2024

NDT

View full text Add to dashboard Cite

show abstract

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Turning the Spotlight on Apathy: Identification and Treatment in Schizophrenia Spectrum Disorders

Cited by 1 publication

References 57 publications

Towards a Non-pharmacological Intervention on Apathy in Korsakoff’s Syndrome: A Systematic Narrative Review Across Different Clinical Conditions

Towards a Non-pharmacological Intervention on Apathy in Korsakoff’s Syndrome: A Systematic Narrative Review Across Different Clinical Conditions

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