Turning weakness into strength: Albumin nanoparticle-redirected amphotericin B biodistribution for reducing nephrotoxicity and enhancing antifungal activity

Liu, Yanchao; Han, Yi; Fang, Ting; Chen, Si-Min; Song, Lijun; Shen, Hui; Dong, Haiqing; Jiang, Yuanying; Zou, Zui; Li, Yongyong; An, Mao‐Mao

doi:10.1016/j.jconrel.2020.05.026

Cited by 17 publications

(14 citation statements)

References 41 publications

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“… The schematic illustrations of the typical representatives of (A) albumin nanoparticles [reproduced with permission from Liu X. et al (2020) ; Liu Y. et al (2020) . Copyright 2020, Elsevier], (B) surface-functionalized albumin nanoparticles [reproduced with permission from Chen et al (2015) .…”

Section: Different Types Of Serum Albumin-based Nanovehiclesmentioning

confidence: 99%

“…Liu et al took advantage of the interaction between AmB and albumin to directly assemble BSA and AmB into larger-sized nanoparticles, which could evade kidney excretion ( Figure 2A ). The obtained AmB-bovine serum albumin (BSA) nanoparticles (AmB-NP) exhibited the efficient AmB loading and reshaped the biodistribution of AmB in vivo , resulting in reduced nephrotoxicity and improved antifungal activity ( Liu Y. et al, 2020 ).…”

Section: Different Types Of Serum Albumin-based Nanovehiclesmentioning

confidence: 99%

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Recent Advancements in Serum Albumin-Based Nanovehicles Toward Potential Cancer Diagnosis and Therapy

Shen

Liu

et al. 2021

Front. Chem.

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Recently, drug delivery vehicles based on nanotechnology have significantly attracted the attention of researchers in the field of nanomedicine since they can achieve ideal drug release and biodistribution. Among the various organic or inorganic materials that used to prepare drug delivery vehicles for effective cancer treatment, serum albumin-based nanovehicles have been widely developed and investigated due to their prominent superiorities, including good biocompatibility, high stability, nontoxicity, non-immunogenicity, easy preparation, and functionalization, allowing them to be promising candidates for cancer diagnosis and therapy. This article reviews the recent advances on the applications of serum albumin-based nanovehicles in cancer diagnosis and therapy. We first introduce the essential information of bovine serum albumin (BSA) and human serum albumin (HSA), and discuss their drug loading strategies. We then discuss the different types of serum albumin-based nanovehicles including albumin nanoparticles, surface-functionalized albumin nanoparticles, and albumin nanocomplexes. Moreover, after briefly discussing the application of serum albumin-based nanovehicles used as the nanoprobes in cancer diagnosis, we also describe the serum albumin-based nanovehicle-assisted cancer theranostics, involving gas therapy, chemodynamic therapy (CDT), phototherapy (PTT/PDT), sonodynamic therapy (SDT), and other therapies as well as cancer imaging. Numerous studies cited in our review show that serum albumin-based nanovehicles possess a great potential in cancer diagnostic and therapeutic applications.

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Section: Different Types Of Serum Albumin-based Nanovehiclesmentioning

confidence: 99%

Section: Different Types Of Serum Albumin-based Nanovehiclesmentioning

confidence: 99%

Recent Advancements in Serum Albumin-Based Nanovehicles Toward Potential Cancer Diagnosis and Therapy

Shen

Liu

et al. 2021

Front. Chem.

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“…This phenomenon indicated that the adsorption of HSA changed the biodistribution of IR‐780 to a certain extent, making it prone to accumulate in the urinary system. The reason may be the formation of nanoparticles (~10 nm) that are easily metabolized by the kidneys (43–45).…”

Section: Resultsmentioning

confidence: 99%

Effects of Human Serum Albumin on the Fluorescence Intensity and Tumor Imaging Properties of IR‐780 Dye

Long

Tan

Liu

et al. 2021

Photochem & Photobiology

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IR‐780 is a lipophilic dye with excellent optical and tumor imaging properties for early tumor diagnostics. Although the mechanism of tumor targeting has not been fully identified, the view that serum albumin plays an important role in tumor accumulation has been recognized. Here, the mechanism of the interaction between IR‐780 and HSA was studied to explore the effect of albumin on its tumor targeting properties. Data demonstrate that IR‐780 can be tightly adsorbed by HSA at a ratio of 1:1 to form a noncovalent complex, which exhibits significant improvement in the near‐infrared fluorescence imaging and tumor diagnosis capacity. During this process, the endogenous fluorescence and esterase activity of HSA are both partially inhibited by IR‐780, and the α‐helical content of HSA slightly increases. Molecular docking simulation displays that the binding site of IR‐780 on HSA is between subdomains IIA and IIB. These results indicate that HSA is an important factor to mediate the optical performance of IR‐780, giving it higher tumor diagnosis capability.

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“…Both A10 and B10 were prepared to have particle sizes ranging from 30–80 nm which were far from sizes prone to distribution in the kidney (less than 10 nm). 44 , 45 Furthermore, it was previously reported that negatively charged nanocarriers had slow glomerular filtration. 45 Also, the tailored MD-α-TOC conjugates possess enhanced antioxidant activities, compared with native vitamin E succinate (see Figure S4 , Supporting Information ) which had a mark in preserving kidney’s architecture and preventing nephrotoxicity associated with free TAC.…”

Section: Resultsmentioning

confidence: 99%

Potential Privilege of Maltodextrin-α-Tocopherol Nano-Micelles in Seizing Tacrolimus Renal Toxicity, Managing Rheumatoid Arthritis and Accelerating Bone Regeneration

Helal¹,

Samy²,

Kamoun³

et al. 2021

IJN

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Background: Tacrolimus (TAC) is a powerful immunosuppressive agent whose therapeutic applicability is confined owing to its systemic side effects. Objective: Herein, we harnessed a natural polymer based bioconjugate composed of maltodextrin and α-tocopherol (MD-α-TOC) to encapsulate TAC as an attempt to overcome its biological limitations while enhancing its therapeutic anti-rheumatic efficacy. Methods: The designed TAC loaded maltodextrin-α-tocopherol nano-micelles (TAC@MDα-TOC) were assessed for their physical properties, safety, toxicological behavior, their ability to combat arthritis and assist bone/cartilage formation. Results: In vitro cell viability assay revealed enhanced safety profile of optimized TAC@MD-α-TOC with 1.6-to 2-fold increase in Vero cells viability compared with free TAC. Subacute toxicity study demonstrated a diminished nephro-and hepato-toxicity accompanied with optimized TAC@MD-α-TOC. TAC@MD-α-TOC also showed significantly enhanced anti-arthritic activity compared with free TAC, as reflected by improved clinical scores and decreased IL-6 and TNF-α levels in serum and synovial fluids. Unique bone formation criteria were proved with TAC@MD-α-TOC by elevated serum and synovial fluid levels of osteocalcin and osteopontin mRNA and proteins expression. Chondrogenic differentiation abilities of TAC@MD-α-TOC were proved by increased serum and synovial fluid levels of SOX9 mRNA and protein expression. Conclusion: Overall, our designed bioconjugate micelles offered an excellent approach for improved TAC safety profile with enhanced anti-arthritic activity and unique bone formation characteristics.

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Turning weakness into strength: Albumin nanoparticle-redirected amphotericin B biodistribution for reducing nephrotoxicity and enhancing antifungal activity

Cited by 17 publications

References 41 publications

Recent Advancements in Serum Albumin-Based Nanovehicles Toward Potential Cancer Diagnosis and Therapy

Recent Advancements in Serum Albumin-Based Nanovehicles Toward Potential Cancer Diagnosis and Therapy

Effects of Human Serum Albumin on the Fluorescence Intensity and Tumor Imaging Properties of IR‐780 Dye

Potential Privilege of Maltodextrin-α-Tocopherol Nano-Micelles in Seizing Tacrolimus Renal Toxicity, Managing Rheumatoid Arthritis and Accelerating Bone Regeneration

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