2021
DOI: 10.1038/s41596-021-00600-7
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Tutorial: using nanoneedles for intracellular delivery

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Cited by 71 publications
(108 citation statements)
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References 215 publications
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“…provides efficient, nonimmunogenic transfection for different tissues 23 , which was confirmed herein for the non-mitogenic corneal endothelium. Future integration of a flexible nanoneedle substrate to conform to the target tissue alongside optimization of nanoneedle topography and surface chemistry to match cell requirements 21,23 should provide desirable enhancements of transfection efficiency.…”
Section: Nanoinjectionsupporting
confidence: 74%
See 3 more Smart Citations
“…provides efficient, nonimmunogenic transfection for different tissues 23 , which was confirmed herein for the non-mitogenic corneal endothelium. Future integration of a flexible nanoneedle substrate to conform to the target tissue alongside optimization of nanoneedle topography and surface chemistry to match cell requirements 21,23 should provide desirable enhancements of transfection efficiency.…”
Section: Nanoinjectionsupporting
confidence: 74%
“…provides efficient, nonimmunogenic transfection for different tissues 23 , which was confirmed herein for the non-mitogenic corneal endothelium. Future integration of a flexible nanoneedle substrate to conform to the target tissue alongside optimization of nanoneedle topography and surface chemistry to match cell requirements 21,23 should provide desirable enhancements of transfection efficiency. These optimization steps would also improve the interfacing with the inner surface of the intact cornea, enabling integration of this approach within current corneal endothelium surgery techniques with minor adaptations for in vivo corneal endothelial gene therapy.…”
Section: Nanoinjectionsupporting
confidence: 74%
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“…Vertically ordered arrays of silicon nanoneedles (Si NNs), because of their nanoscale size, low toxicity, and slow biodegradability (i.e., <20 nm day −1 in physiological conditions), are of particular interest for minimally invasive and long-term sustained drug delivery (12)(13)(14). For therapeutic delivery, the surface of Si NNs can be functionalized to accommodate various drug molecules such as steroids, hormones, proteins, and anticancer agents, and then injected percutaneously or intraperitoneally in humans without notable side effects (15).…”
Section: Introductionmentioning
confidence: 99%