Twelfth International Foamy Virus Conference—Meeting Report

Herchenröder, Ottmar; Löchelt, Martin; Buseyne, Florence; Gessain, Antoine; Soares, Marcelo A.; Khan, Arifa S.; Lindemann, Dirk

doi:10.3390/v11020134

Cited by 3 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An interesting feature of FVs is their ability to infect a diverse range of cell types and cause a characteristic foam-like cytopathic effect in culture system. However, they appear to be non-pathogenic in either naturally or accidentally infected hosts with a currently "emerging" but still ill-defined capacity to affect blood or kidney parameters without overt clinical consequences [11,95,96]. This suggests that the host immune system controls viral infection and/or FV replication in vivo.…”

Section: Innate Immunitymentioning

confidence: 99%

Bovine Foamy Virus: Shared and Unique Molecular Features In Vitro and In Vivo

Materniak-Kornas

Tan

Heit-Mondrzyk

et al. 2019

Viruses

Self Cite

View full text Add to dashboard Cite

The retroviral subfamily of Spumaretrovirinae consists of five genera of foamy (spuma) viruses (FVs) that are endemic in some mammalian hosts. Closely related species may be susceptible to the same or highly related FVs. FVs are not known to induce overt disease and thus do not pose medical problems to humans and livestock or companion animals. A robust lab animal model is not available or is a lab animal a natural host of a FV. Due to this, research is limited and often focused on the simian FVs with their well-established zoonotic potential. The authors of this review and their groups have conducted several studies on bovine FV (BFV) in the past with the intention of (i) exploring the risk of zoonotic infection via beef and raw cattle products, (ii) studying a co-factorial role of BFV in different cattle diseases with unclear etiology, (iii) exploring unique features of FV molecular biology and replication strategies in non-simian FVs, and (iv) conducting animal studies and functional virology in BFV-infected calves as a model for corresponding studies in primates or small lab animals. These studies gained new insights into FV-host interactions, mechanisms of gene expression, and transcriptional regulation, including miRNA biology, host-directed restriction of FV replication, spread and distribution in the infected animal, and at the population level. The current review attempts to summarize these findings in BFV and tries to connect them to findings from other FVs.

show abstract

Section: Innate Immunitymentioning

confidence: 99%

Bovine Foamy Virus: Shared and Unique Molecular Features In Vitro and In Vivo

Materniak-Kornas

Tan

Heit-Mondrzyk

et al. 2019

Viruses

Self Cite

View full text Add to dashboard Cite

show abstract

“…These features may allow us to track the development and evolution of their unique molecular biology and to identify or at least postulate mechanisms that (may) have led to this mosaic of unique and unconventional features. Unravelling the basic mechanisms of FV biology has already opened new avenues of FV vector development, but may also shed new light into the evolution of their apparent apathogenicity and peaceful co-evolution/co-habitation with their hosts [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Unique, the Known, and the Unknown of Spumaretrovirus Assembly

Lindemann

Hütter

Wei

et al. 2021

Viruses

Self Cite

View full text Add to dashboard Cite

Within the family of Retroviridae, foamy viruses (FVs) are unique and unconventional with respect to many aspects in their molecular biology, including assembly and release of enveloped viral particles. Both components of the minimal assembly and release machinery, Gag and Env, display significant differences in their molecular structures and functions compared to the other retroviruses. This led to the placement of FVs into a separate subfamily, the Spumaretrovirinae. Here, we describe the molecular differences in FV Gag and Env, as well as Pol, which is translated as a separate protein and not in an orthoretroviral manner as a Gag-Pol fusion protein. This feature further complicates FV assembly since a specialized Pol encapsidation strategy via a tripartite Gag-genome–Pol complex is used. We try to relate the different features and specific interaction patterns of the FV Gag, Pol, and Env proteins in order to develop a comprehensive and dynamic picture of particle assembly and release, but also other features that are indirectly affected. Since FVs are at the root of the retrovirus tree, we aim at dissecting the unique/specialized features from those shared among the Spuma- and Orthoretrovirinae. Such analyses may shed light on the evolution and characteristics of virus envelopment since related viruses within the Ortervirales, for instance LTR retrotransposons, are characterized by different levels of envelopment, thus affecting the capacity for intercellular transmission.

show abstract

Avian and serpentine endogenous foamy viruses, and new insights into the macroevolutionary history of foamy viruses

Aiewsakun

2020

Virus Evolution

View full text Add to dashboard Cite

This study reports and characterises two novel distinct lineages of foamy viruses (FVs) in the forms of endogenous retroviruses (ERVs). Several closely related elements were found in the genome of oriental stork (Ciconia boyciana) and other was found in the genome of spine-bellied sea snake (Hydrophis hardwickii), designated ERV-Spuma.N-Cbo (where 'N' runs from one to thirteen) and ERV-Spuma.1-Hha, respectively. This discovery of avian and serpentine endogenous FVs adds snakes, and perhaps more crucially, birds to the list of currently known hosts of FVs, in addition to mammals, reptiles, amphibians, and fish. This indicates that FVs are, or at least were, capable of infecting all major lineages of vertebrates. Moreover, together with other FVs, phylogenetic analyses showed that both of them are most closely related to mammalian FVs. Further examination revealed that reptilian FVs form a deep paraphyletic group that is basal to mammalian and avian FVs, suggesting that there were multiple ancient FV cross-class transmissions among their hosts. Evolutionary timescales of various FV lineages were estimated in this study, in particular, the timescales of reptilian FVs and that of the clade of mammalian, avian, and serpentine FVs. This was accomplished by using the recently established time-dependent rate phenomenon models, inferred using mainly the knowledge of the co-speciation history between FVs and mammals. It was found that the estimated timescales matched very well with those of reptiles. Combined with the observed phylogenetic patterns, these results suggested that FVs likely co-speciated with ancient reptilian animals, but later jumped to a protomammal and/or a bird, which ultimately gave rise to mammalian and avian FVs. These results contribute to our understanding of FV emergence, specifically the emergence of mammalian and avian FVs, and provide new insights into how FVs co-evolved with their non-mammalian vertebrate hosts in the distant past.

show abstract

Twelfth International Foamy Virus Conference—Meeting Report

Cited by 3 publications

References 36 publications

Bovine Foamy Virus: Shared and Unique Molecular Features In Vitro and In Vivo

Bovine Foamy Virus: Shared and Unique Molecular Features In Vitro and In Vivo

The Unique, the Known, and the Unknown of Spumaretrovirus Assembly

Avian and serpentine endogenous foamy viruses, and new insights into the macroevolutionary history of foamy viruses

Contact Info

Product

Resources

About