Twelve natural estrogens in urines of swine and cattle: Concentration profiles and importance of eight less-studied

Zhao, Tao; Wan, Yi-ping; Liu, Zehua; Wang, Hao; Dang, Zhi; Liu, Yu

doi:10.1016/j.scitotenv.2021.150042

Cited by 21 publications

(7 citation statements)

References 46 publications

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“…Furthermore, considerable evidence supports that E2 is a neuromodulator of learning and memory in human brain ( Taxier et al, 2020 ). As one of the potential environmental endogenous estrogens, human and mammal urine and feces contain E2 ( Zhang et al, 2014 ; Tang et al, 2022b ; Tang et al, 2022a ). Due to human and animal excretions, E2 can contaminate water resources and aquatic animals through the sewage treatment plant outlet or man-made direct discharge ( Liu et al, 2012a ).…”

Section: Introductionmentioning

confidence: 99%

17β-estradiol biosensors based on different bioreceptors and their applications

Wang,

Kong,

Liu

et al. 2024

Front. Bioeng. Biotechnol.

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17β-Estradiol (E2) is a critical sex steroid hormone, which has significant effects on the endocrine systems of both humans and animals. E2 is also believed to play neurotrophic and neuroprotective roles in the brain. Biosensors present a powerful tool to detect E2 because of their small, efficient, and flexible design. Furthermore, Biosensors can quickly and accurately obtain detection results with only a small sampling amount, which greatly meets the detection of the environment, food safety, medicine safety, and human body. This review focuses on previous studies of biosensors for detecting E2 and divides them into non-biometric sensors, enzyme biosensors, antibody biosensors, and aptamer biosensors according to different bioreceptors. The advantages, disadvantages, and design points of various bioreceptors for E2 detection are analyzed and summarized. Additionally, applications of different bioreceptors of E2 detection are presented and highlight the field of environmental monitoring, food and medicine safety, and disease detection in recent years. Finally, the development of E2 detection by biosensor is prospected.

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Section: Introductionmentioning

confidence: 99%

17β-estradiol biosensors based on different bioreceptors and their applications

Wang,

Kong,

Liu

et al. 2024

Front. Bioeng. Biotechnol.

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“…3 Nevertheless, E2 content in animal feeds is not prohibited in many countries; therefore, the released E2 from livestock and poultry industries into the environment and the detected E2 in milk and meat have been continuously reported. [4][5][6][7] To detect E2 in samples, the analyses by gas chromatography-mass spectrometer (GC-MS) and high-performance liquid chromatography (HPLC) were commonly accepted. Although these techniques are highly sensitive and accurate, they have several disadvantages: time-consuming, complicated steps of sample preparation, use of an expensive instrument, operation by an experienced technician, and use of organic solvent at high volume.…”

Section: Introductionmentioning

confidence: 99%

“…According to human safety concerns, E2 quantity in animal feeds is regulated by several countries, such as the regulation for no E2 in animal feeds according to the Codex Alimentarius Commission (CAC) and the National Food Safety Standards of China 3 . Nevertheless, E2 content in animal feeds is not prohibited in many countries; therefore, the released E2 from livestock and poultry industries into the environment and the detected E2 in milk and meat have been continuously reported 4–7 . To detect E2 in samples, the analyses by gas chromatography‐mass spectrometer (GC‐MS) and high‐performance liquid chromatography (HPLC) were commonly accepted.…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive colorimetric aptasensor for 17β‐estradiol detection in milk based on the repetitive‐loop aptamer

Kongpreecha

Chumpol

Siri

2023

Biotech and App Biochem

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Trace of 17β‐estradiol (E2) contamination in food has been a concern for its negative impacts on human health, leading to the need for an E2‐monitoring system. This work reported a new simple, sensitive, and colorimetric E2 detection based on the designed repetitive‐loop aptamer and gold nanoparticles (AuNPs). The designed aptamers (L2–L5) exhibited a higher binding capability to E2 than the original truncated aptamer (L1). Although L3–L5 aptamers exhibited the highest binding capability, only L3‐aptasensor demonstrated the sensitive detection of E2 in a range of 0.05−0.8 nM, with the limit of detection at 13.1 pM. The developed L3‐aptasensor was 7.7‐folds more sensitive for E2 detection than the L1‐aptasensor. It selectively detected E2, but not the other tested chemicals with similar structures: progesterone, genistein, diethylstilbestrol, bisphenol A, and chloramphenicol. The L3‐aptasensor efficiently detected E2 spiked in milk samples within the precision acceptance criterion of recovery rates (100.1%−113.0%) and the relative standard deviations (5.24%−11.06%). These results demonstrated the development of a new aptasensor based on the designed repetitive‐loop aptamer that could enhance E2‐detection sensitivity and be potentially used for detecting E2 in milk samples with high accuracy and reliability.

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“…The presence of these harmful compounds in wastewater and aquatic ecosystems is mostly due to farm animal excretions in livestock breeding activities 6 and has recently become a major environmental concern 7 – 9 ; these molecules seem in fact to be responsible for development, fertility, and reproductive function impairment in mammals, fish, and amphibian populations. Indeed, intersex fish populations have been observed worldwide in estrogen-contaminated ecosystems[ 5 , 6 , 10 – 12 and references therein].…”

Section: Introductionmentioning

confidence: 99%

Bioconversion of 4-hydroxyestradiol by extradiol ring-cleavage dioxygenases from Novosphingobium sp. PP1Y

Mensitieri

Bosso

Piaz

et al. 2023

Sci Rep

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Livestock breeding activities and pharmaceutical wastes lead to considerable accumulation of steroid hormones and estrogens in wastewaters. Here estrogens act as pro-cancerogenic agents and endocrine disruptors interfering with the sexual development of aquatic animals and having toxic effects in humans. Environmental bacteria play a vital role in estrogens degradation. Their wide reservoir of enzymes, such as ring cleavage dioxygenases (RCDs), can degrade the steroid nucleus, catalyzing the meta-cleavage of A, B or D steroid rings. In this work, 4 extra-diol ring cleavage dioxygenases (ERCDs), PP28735, PP26077, PP00124 and PP00193, were isolated from the marine sphingomonad Novosphingobium sp. PP1Y and characterized. Enzymes kinetic parameters were determined on different synthetic catecholic substrates. Then, the bioconversion of catechol estrogens was evaluated. PP00124 showed to be an efficient catalyst for the degradation of 4-hydroxyestradiol (4-OHE2), a carcinogenic hydroxylated derivate of E2. 4-OHE2 complete cleavage was obtained using PP00124 both in soluble form and in whole recombinant E. coli cells. LC–MS/MS analyses confirmed the generation of a semialdehyde product, through A-ring meta cleavage. To the best of our knowledge, PP00124 is the first characterized enzyme able to directly degrade 4-OHE2 via meta cleavage. Moreover, the complete 4-OHE2 biodegradation using recombinant whole cells highlighted advantages for bioremediation purposes.

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Twelve natural estrogens in urines of swine and cattle: Concentration profiles and importance of eight less-studied

Cited by 21 publications

References 46 publications

17β-estradiol biosensors based on different bioreceptors and their applications

17β-estradiol biosensors based on different bioreceptors and their applications

Highly sensitive colorimetric aptasensor for 17β‐estradiol detection in milk based on the repetitive‐loop aptamer

Bioconversion of 4-hydroxyestradiol by extradiol ring-cleavage dioxygenases from Novosphingobium sp. PP1Y

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