Twelve‐year follow‐up after discontinuation of preseasonal grass pollen immunotherapy in childhood

Eng, P. A.; Borer-Reinhold, M.; Heijnen, Ingmar; Gnehm, Hanspeter

doi:10.1111/j.1398-9995.2006.01011.x

Cited by 247 publications

(201 citation statements)

References 13 publications

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“…27 Efficacy evaluation (symptoms and rescue medication intake) was done 6 and 12 years after stopping SIT. This group was compared with a nondesensitized control group.…”

Section: Indications and Contraindicationsmentioning

confidence: 99%

Specific immunotherapy in grass pollen allergy

Mailhol

Didier²

2012

Human Vaccines & Immunotherapeutics

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“…27 Efficacy evaluation (symptoms and rescue medication intake) was done 6 and 12 years after stopping SIT. This group was compared with a nondesensitized control group.…”

Section: Indications and Contraindicationsmentioning

confidence: 99%

Specific immunotherapy in grass pollen allergy

Mailhol

Didier²

2012

Human Vaccines & Immunotherapeutics

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“…Eng ve ark. (17,18), üç yıl üst üste mevsim öncesi immunoterapi yapılan çocuklarda tedavinin bitiminden altı yıl ve 12 yıl sonra bile kontrol grubuyla karşılaştırıldı-ğında anlamlı klinik etkinlik görüldüğünü bildirmişlerdir.…”

Section: Discussionunclassified

Evaluation of Preseasonal Immunotherapy in Patients with Seasonal Allergic Rhinitis

Tepetam¹,

Ferhan²

2014

J Chest Dis Crit Care

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The aim of the present study was to evaluate clinical and laboratory efficacy of short term preseasonal immunotherapy by comparing immunotherapy (IT) and medical treatment administered to patients diagnosed with seasonal allergic rhinitis (AR). Patients were randomized into two groups: ie those who use preseasonal immunotherapy and drugs according to their need (IT group:12 patients ) Mevsimsel Alerjik Rinitli Hastalarda Mevsim Öncesi İmmünoterapi Etkinliğinin Değerlendirilmesi ÖZET Çalışmamızda, mevsimsel allerjik rinit (AR) tanısı koyduğumuz hastalara uygulanan mevsim öncesi immünoterapi (IT) ile medikal tedavi stratejilerini karşılaştırarak, mevsim öncesi kısa süreli immünoterapinin klinik ve laboratuvar etkinliğini değerlendirmeyi amaçladık. Hastalar mevsim öncesi IT tedavisi ile polen sezonunda ihtiyaca göre ilaç kullananlar (IT grup:12 hasta)

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“…Table 1 shows descriptive data for the 18 systematically reviewed studies (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37). [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] and seven adult studies (31-37) included a total of 11 106 patients (1049 children, 10 057 adults), of which 8369 (75.6%) were included only in the Purello D'Ambrosio study (31). Nine of 18 studies were conducted in Italy (21,22,24,25,29,31,(33)(34)(35), four in Turkey, and (26)…”

Section: Resultsmentioning

confidence: 99%

“…Our search strategy identified 1378 unique publications, including over 338 peer-reviewed studies published from inception to June 30, 2015 finally retrieved , of which 18 met the inclusion criteria (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37). We excluded the Jacobsen study (38), because the outcome was reported in a subgroup of patients regardless of the treatment received, the Eifan (39) Acquistapace (40), Szepfalusi (41), and Shao (42) studies because they were not long-term studies (<3 years of treatment/follow-up).…”

Section: Resultsmentioning

confidence: 99%

Efficacy of allergen immunotherapy in reducing the likelihood of developing new allergen sensitizations: a systematic review

Bona

Plaia

Leto-Barone

et al. 2017

Allergy

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Background: Guidelines and position papers indicate that allergen immunotherapy (AIT) is the only disease-modifying treatment, including prevention of the onset of new allergen sensitizations. However, this preventive effect was shown by only a few observational studies. Our aim was to systematically review the efficacy of AIT in preventing the onset of new allergen sensitizations. Methods: Computerized bibliographic searches of Medline, EMBASE, and the Cochrane Library (through June 2015) were supplemented with manual searches of reference lists. Observational studies or randomized controlled trials with a longterm observation period were included. Paired reviewers extracted data about study characteristics and assessed biases. The end point was the risk difference in the onset of new allergen sensitizations between patients treated with AIT and pharmacotherapy. The strength of the evidence was graded based on the risk of bias, consistency, and magnitude of effect, according to the GRADE Working Group's guide. Results: Eighteen studies (1049 children, 10 057 adults) met the inclusion criteria. The risk of bias was high in all but one study. Low evidence supports the position that AIT prevents the onset of new allergen sensitizations, with 10 of 18 studies reporting a reduction in the onset of new sensitizations in patients treated with AIT vs placebo. Small studies and studies with a shorter follow-up showed the highest benefit of AIT. Conclusions: The overall evidence provides a low-grade level of the evidence supporting the efficacy of AIT in preventing the onset of new allergen sensitizations, but high-quality studies could change this estimate.

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Twelve‐year follow‐up after discontinuation of preseasonal grass pollen immunotherapy in childhood

Abstract: This prospective controlled prolonged follow-up study demonstrates the ongoing clinical benefit 12 years after discontinuation of SIT. Furthermore, the reduction in onset of new sensitization, which was found 6 years after discontinuation of SIT, is sustained 6 years later.

Cited by 247 publications

References 13 publications

Specific immunotherapy in grass pollen allergy

Specific immunotherapy in grass pollen allergy

Evaluation of Preseasonal Immunotherapy in Patients with Seasonal Allergic Rhinitis

Efficacy of allergen immunotherapy in reducing the likelihood of developing new allergen sensitizations: a systematic review

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