Carbon capture and storage (CCS) is seen as an important solution to solve the twin challenge of reducing GHG emissions, while utilizing fossil fuel reserves to meet future energy requirements. In this study an innovation systems perspective is applied to review the development of CCS technologies in the US between 2000 and 2009 and to come up with policy recommendations for technology managers that wish to accelerate the deployment of CCS. The analysis describes the successful built-up of an innovation system around CCS and pinpoints the key determinants for this achievement. However, the evaluation of the system's performance also indicates that America's leading role in the development of CCS should not be taken for granted. It shows that the large CCS R&D networks, as well as the extensive CCS knowledge base, which have been accumulated over the past decade, have not yet been valorized by entrepreneurs to explore the market for integrated CCS concepts linked to power generation. Therefore, it is argued that the build-up of the innovation system has entered a critical phase that is decisive for a further thriving development of CCS technologies in the US. This study provides a clear understanding of the current barriers to the technology's future deployment and outlines a policy strategy that (1) stimulates technological learning; (2) facilitates collaboration and coordination in CCS actor networks; (3) creates financial and market incentives for the technology; and (4) provides supportive regulation and sound communication on CCS.