Twenty‐eight‐year review of childhood renal diseases from renal biopsy data: A single centre in China

Abstract

The incidence patterns of paediatric renal diseases changed over the 28-year period of this study. Our results show that different renal diseases characterize different age intervals. Furthermore, there are several associations between clinical presentation and biopsy features in childhood renal disease.

The Spectrum of Biopsy-Proven Glomerular Diseases among Children in China

“…In our series, there was a predominance of boys (68%), which was consistent with previous studies that reported a higher proportion of boys in patients with pediatric glomerulopathy (6,8,25,28). It might be attributable to the higher susceptibility of boys to major glomerular diseases, such as minimal change disease and IgA nephropathy.…”

“…Mesangial proliferative GN was reported to be the most common glomerulopathy in India (33), whereas IgA nephropathy was reported as the most frequent pattern of pediatric glomerular disease in Korea (34) and Italy (35). In several single-center studies conducted in China (25,36), minimal change disease or IgA nephropathy was identified as the most common pediatric glomerular disease. The variation in the spectrum of pediatric glomerulopathies in studies from different countries may result from the differences in biopsy indications, patient referral, and racial predisposition to different nephropathies (25,37,38).…”

“…In several single-center studies conducted in China (25,36), minimal change disease or IgA nephropathy was identified as the most common pediatric glomerular disease. The variation in the spectrum of pediatric glomerulopathies in studies from different countries may result from the differences in biopsy indications, patient referral, and racial predisposition to different nephropathies (25,37,38). Up to date, there is no standard indication or guideline for kidney biopsies among children.…”

“…More detailed information on the spectrum of pediatric glomerular diseases and their clinicopathologic correlations across different sexes and age groups will contribute to more accurate clinical diagnosis when kidney biopsies are not available and will help to optimize the management of pediatric glomerular diseases. To date, there are only a few small single-centered studies on the composition of glomerular diseases among pediatric patients in China (25). Nationwide epidemiologic data on the spectrum of biopsy-proven glomerular diseases among children are currently limited.…”

Mesangial proliferative glomerulonephritis: A glomerular disease or a non‐specific morphological change?

“…We read with interest the recent publication by Jiang et al reporting the clinicopathological characteristics of biopsy‐proven childhood renal diseases at a centre in Guangzhou, China. Notably, the third leading cause of primary glomerular disease after IgA nephritis (27.6%) and minimal change disease (24.0%) was “mesangial proliferative glomerulonephritis” (16.9%), a diagnosis 2.7 times more frequent than focal segmental glomerulosclerosis (6.3%) and 4.6 times more frequent than endocapillary proliferative glomerulonephritis (3.7%).…”