Twenty-four hour ambulatory blood pressure in a population of elderly men

Björklund, Kristina; Lind, Lars; Lithell, Hans

doi:10.1046/j.1365-2796.2000.00760.x

Cited by 23 publications

(16 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The threshold for elevated ambulatory daytime BP in this study (Ն135/85 mm Hg) has been proposed based on previous studies of ambulatory BP normality in different populations 15,31 and is also close to the daytime ambulatory BP (137/83 mm Hg) that by linear regression corresponded to an office BP of 140/90 in the present study population. 14 In conclusion, the present study in an elderly population showed for the first time that isolated ambulatory hypertension was a predictor of increased cardiovascular morbidity, independent of office BP and other established cardiovascular risk factors. The findings suggest that important prognostic information may be undetected when BP is measured only in the clinical setting.…”

Section: Discussionsupporting

confidence: 51%

Isolated Ambulatory Hypertension Predicts Cardiovascular Morbidity in Elderly Men

et al. 2003

View full text Add to dashboard Cite

Background-Little is known about isolated ambulatory hypertension, a state with elevated ambulatory but normal office blood pressure (BP). This study aimed to investigate the prognostic significance of isolated ambulatory hypertension for cardiovascular morbidity in a population of elderly men. Methods and Results-At baseline, 24-hour ambulatory BP and metabolic and cardiac risk profiles were evaluated in 578 untreated 70-year-old men, participants of a population-based cohort. Subjects with isolated ambulatory hypertension (office BP Ͻ140/90 and daytime BP Ն135/85) and sustained hypertension (office BP Ն140/90 and daytime BP Ն135/85) had increased plasma glucose, body mass index, and echocardiographically determined left ventricular relative wall thickness compared with normotensive subjects (office BP Ͻ140/90 and daytime BP Ͻ135/85). Seventy-two cardiovascular morbid events (2.37 per 100 person-years at risk) occurred over 8.

show abstract

Section: Discussionsupporting

confidence: 51%

Isolated Ambulatory Hypertension Predicts Cardiovascular Morbidity in Elderly Men

et al. 2003

View full text Add to dashboard Cite

show abstract

“…19 This limit is also close to the daytime pressure (137/83 mm Hg) that by linear regression analysis corresponded to an office BP of 140/90 mm Hg in the present study population. 18 A more restrictive definition (130/ 80 mm Hg) was used in a separate analysis to investigate the importance of the upper limit of normal ABP level, but it did not substantially change the results (data not shown).…”

Section: Discussionmentioning

confidence: 99%

“…Reading and data editing have been described in a previous study. 18 We defined white-coat hypertension as office BP Ն140/90 and daytime BP Ͻ135/85 mm Hg and sustained hypertension as office BP Ն140/90 and daytime BP Ն135/85 mm Hg. 19 The methods for anthropometric measurements and analysis of fasting serum triglycerides, cholesterol, and nonesterified fatty acids, as well as oral glucose tolerance test, have previously been described.…”

Section: Measurements At Age 70 Yearsmentioning

confidence: 99%

Different Metabolic Predictors of White-Coat and Sustained Hypertension Over a 20-Year Follow-Up Period

et al. 2002

View full text Add to dashboard Cite

Background-The clinical significance of white-coat hypertension is still unclear. Moreover, no study has examined metabolic predictors of white-coat versus sustained hypertension. Methods and Results-We investigated men (nϭ602) in a longitudinal population-based cohort who at age 70 years were identified as normotensive, white-coat hypertensive (office blood pressure [BP] Ն140/90 and daytime ambulatory BP Ͻ135/85 mm Hg), and sustained hypertensive (office BP Ն140/90 and daytime ambulatory BP Ն135/85 mm Hg). At baseline, when the subjects were aged 50 years, blood glucose, insulin, lipids, and fatty acid composition of the serum cholesterol esters were analyzed. The investigations at age 70 years included determination of insulin sensitivity and target organ damage. At age 50 years, individuals who 20 years later were identified as white-coat hypertensive or sustained hypertensive showed significantly elevated BP, heart rate, and impaired glucose tolerance compared with normotensive subjects but white coat hypertensive subjects were leaner and had a more favorable serum cholesterol ester fatty acid profile than did sustained hypertensive subjects. At age 70 years, both white-coat and sustained hypertensive subjects showed an impaired insulin sensitivity, elevated blood glucose, and increased serum insulin and heart rate compared with normotensive subjects, but left ventricular mass and urinary albumin excretion were increased only in sustained hypertensive subjects. Conclusions-These findings indicate that although metabolic abnormalities and elevated heart rate were consistent over time in both hypertensive groups, a lower body mass index and more favorable dietary fat composition predicted the development of white-coat as opposed to sustained hypertension over 20 years. (Circulation. 2002;106:63-68.)

show abstract

“…There seem to be only minor natural blood pressure alterations during this time in healthy elderly men. (Bjorklund et al, 2000) In patients suffering from OH the orthostatic reaction and its symptoms may be worse in the morning. (Mathias et al, 1999a;Mathias et al, 1999b) In this study 82% of the controls, 51% of the AD patients and 61% of the DLB patients had their orthostatic measurements carried out before noon.…”

Section: Discussionmentioning

confidence: 99%

The period of hypotension following orthostatic challenge is prolonged in dementia with Lewy bodies

Andersson

Hansson

Minthon

et al. 2007

Int J Geriat Psychiatry

View full text Add to dashboard Cite

ObjectivesTo determine whether orthostatic hypotension (OH) is more common in patients with dementia than in older people without cognitive impairment and to identify key differences in the profile of the orthostatic response and the pulse drive during orthostatic challenge between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB).MethodsThe orthostatic response was evaluated in 235 patients with AD, 52 patients with DLB and 62 elderly controls. The blood pressure and pulse rate were measured in supine position, immediately after standing up and after 1, 3, 5 and 10 min of standing. OH was defined as a reduction of systolic blood pressure (SBP) of at least 20 mm Hg or a reduction of diastolic blood pressure (DBP) of at least 10 mm Hg.ResultsOH occurred in 69% of the DLB patients and in 42% of the AD patients, but only in 13% of the controls (p < 0.001 controls vs AD and controls vs DLB, p = 0.001 AD vs DLB) The DLB patients had a greater drop in SBP than the other study groups during orthostatic challenge and had a more prolonged period of orthostasis. The pulse drive on orthostatic challenge was similar in between groups. However, in the DLB group it was not adequate to restore the blood pressure to supine values.ConclusionsPatients with DLB react different to orthostatic challenge than patients with AD or controls, with important clinical implications for key disease symptoms and treatment. Copyright © 2007 John Wiley & Sons, Ltd.

show abstract

Twenty-four hour ambulatory blood pressure in a population of elderly men

Abstract: Our results provide a basis for 24 h ambulatory blood pressure reference values in elderly men. The study confirms previous findings of a high prevalence of hypertension at older age. It also indicates that blood pressure is inadequately controlled in elderly treated hypertensives.

Cited by 23 publications

References 37 publications

Isolated Ambulatory Hypertension Predicts Cardiovascular Morbidity in Elderly Men

Isolated Ambulatory Hypertension Predicts Cardiovascular Morbidity in Elderly Men

Different Metabolic Predictors of White-Coat and Sustained Hypertension Over a 20-Year Follow-Up Period

The period of hypotension following orthostatic challenge is prolonged in dementia with Lewy bodies

Contact Info

Product

Resources

About