Twenty-four-hour ambulatory blood pressure in community-dwelling elderly men and women, aged 60???102 years

OʼSullivan, C.; Duggan, Joe; Atkins, Neil; O’Brien, Eoin

doi:10.1097/00004872-200309000-00012

Cited by 28 publications

(11 citation statements)

References 25 publications

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“…Our results in a larger population support the finding that men have a higher BP than women, and extend them to obese patients. In general, BP is higher in men than in women below the age of 59 years (the age group of most of our patients), and similar 15 or even greater in women after menopause. 7,8 Kotsis et al 16 found a significantly increased BP assessed by ABPM in a large population of obese patients compared to subjects with normal weights.…”

Section: Discussionmentioning

confidence: 48%

Gender differences in ambulatory blood pressure monitoring profile in obese, overweight and normal subjects

Kagan

Faibel²,

Ben-Arie

et al. 2006

J Hum Hypertens

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The incidence of obesity has increased enormously in the past several decades, and has been described as a modern epidemic. Obesity is a major factor contributing to hypertension. To the best of our knowledge, no study of ambulatory blood pressure monitoring (ABPM) comparing men with women in relation to body mass indexes (BMI) has been performed. From December 2002 to May 2006, we performed 24-h ABPM in 5950 subjects (3102 men and 2848 women), with a wide range of BMI (range 15.9-53.2 kg/m 2 ). We defined obese subjects as those with BMIX30.0 kg/m 2 , overweight subjects as those with BMI425.0 and o30.0 kg/m 2 , and normal subjects as those with BMIp25.0 kg/m 2 . Data on 989 subjects (501 men and 488 women) aged from X18 to p69 years without antihypertensive treatment, atrial fibrillation or diabetes were included for analysis. We consistently found that obese men had the expected increased heart rate compared to normal and overweight men, whereas women (normal, overweight and obese) had similar HRs. In addition, normal and obese women had similar diastolic blood pressures (BP), as opposed to obese men, who had raised diastolic BP. These results may indicate that different pathogenetic mechanisms may be involved in the relationship between obesity and hypertension in men and women.

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Section: Discussionmentioning

confidence: 48%

Gender differences in ambulatory blood pressure monitoring profile in obese, overweight and normal subjects

Kagan

Faibel²,

Ben-Arie

et al. 2006

J Hum Hypertens

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“…This cross-sectional study cannot determine whether the association between nondipping and PWV is a cause or effect relationship, although both conditions appear to share certain risk factors, such as altered sympathoadrenal activity [28,29] and raised inflammatory markers [30,31]. Both PWV and the prevalence of nondipper status become more common with increasing age [1,10,32], suggesting that they may both reflect a progression to end-organ damage. In prospectively studied type-1 diabetic adolescents, loss of the nocturnal dip preceded the development of microalbuminuria, suggest-ing that nondipping may be an early indicator of risk [33].…”

Section: Discussionmentioning

confidence: 99%

Circadian blood pressure variation: relationship between dipper status and measures of arterial stiffness

Jerrard-Dunne

Mahmud

Feely

2007

Journal of Hypertension

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A reverse-dipper pattern, corresponding to the 95% percentile of the night: day BP ratio on ambulatory BP monitoring, identifies a population group with increased PWV. This difference could not be explained by the measured risk factors. Reverse-dippers had significantly less day: night variability in heart rate and wider pulse pressures at night than any of the other groups, suggesting altered sympathetic tone at night as a potential mechanism.

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“…26 Experience from a previous study involving very elderly subjects indicated that healthy subjects in this age group commonly had conventional SBP levels Ͼ140 mm Hg. 27 Indeed, SBP levels Ͻ140 mm Hg in the very elderly have been associated with frailty and illness rather than "healthy ageing." 4,28 Recruitment of an age-matched control group required recognition of the age-associated rise in SBP and setting a higher threshold for NT.…”

Section: Discussionmentioning

confidence: 99%

Hypertensive Target-Organ Damage in the Very Elderly

et al. 2003

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Abstract-In people aged Ͼ80 years, the so-called very elderly, there is uncertainty about the relation between hypertension and cardiovascular morbidity. The aims of this study were to investigate whether hypertension in people aged Ͼ80 years is associated with target-organ damage, over and above the effects of age, and to determine whether ambulatory blood pressure monitoring (ABPM) could improve on conventional blood pressure monitoring (CBPM) in predicting target-organ damage. Investigations included echocardiographic measurement of left ventricular mass index (LVMI), brain magnetic resonance imaging assessment of periventricular hyperintensity (PVH), urinary albumin-creatinine ratio (ACR), aortic pulse wave velocity (PWV), and 24-hour ABPM. Forty-three subjects, at a mean age 84.3 years, were studied, 22 normotensive (NT) and 21 hypertensive (HT). CBP was 184/89 and 145/76 mm Hg in the HT and NT groups, respectively. In men, LVMI was significantly greater in HT subjects, 157Ϯ37 vs 123Ϯ15 g/m 2 in NT subjects (PϽ0.05). In women, LVMI was similar in both groups. Urinary ACR was greater in HT than in NT subjects (log ACR, 1.21Ϯ0.50 vs 0.95Ϯ0.23; PϽ0.05). Cerebral PVH grade was higher in the HT subjects (2.6Ϯ0.8 vs 2.2Ϯ0.9), although this difference was not significant. Aortic PWV did not differ between the 2 groups. ABPM was positively associated with urinary ACR and cerebral PVH, independent of its correlation with CBPM. In advanced old age, HT is associated with evidence of target-organ damage. ABPM can improve on CBPM in predicting very elderly subjects with HT target-organ damage.

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Twenty-four-hour ambulatory blood pressure in community-dwelling elderly men and women, aged 60???102 years

Cited by 28 publications

References 25 publications

Gender differences in ambulatory blood pressure monitoring profile in obese, overweight and normal subjects

Gender differences in ambulatory blood pressure monitoring profile in obese, overweight and normal subjects

Circadian blood pressure variation: relationship between dipper status and measures of arterial stiffness

Hypertensive Target-Organ Damage in the Very Elderly

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