Twenty-Four-Hour Canine Lung Preservation Using Uw Solution

Pulmonary preservation studies: effects on endothelial function and pulmonary adenine nucleotides

“…MEC has been shown to provide adequate lung preservation for up to 8 hr of ischemia (18). However, MEC has also been shown to produce higher airway pressures and pulmonary vascular resistance after long ischemic periods compared with UW in a canine isolated lung model (19).…”

The relationship of ischemia-reperfusion injury of transplanted lung and the up-regulation of major histocompatibility complex II on host peripheral

“…For many years IRI has been suggested to be one of the etiologic factors in the rejection of transplanted organs. 1,2,4 Initial clinical observations reported more persistent and more severe rejection of organs that had extended ex vivo preservation times in comparison to organs transplanted within expected preservation times. 3 These observations triggered the interest of investigators to determine whether factors in addition to tissue incompatibility are involved in organ rejection.…”

“…I schemia-reperfusion injury (IRI) and graft rejection are considered to be independent problems in the management of solid organ transplantation. 1,2 Rejection of transplanted organs is thought to be solely related to the problem of tissue incompatibility. 3 Recently, however, a link between IRI and organ rejection has been made.…”

“…The specific aims of this protocol included the following: (1) to evaluate the relationship between ex vivo preservation time, extent of lung damage, and the up-regulation of MHC II, (2) to determine whether IRI is capable of the up-regulating of MHC II independent of allogenicity, and (3) to examine whether the type of ischemic insult (warm versus cold) differently affects MHC II up-regulation. We hypothesized that IRI induced by ex vivo preservation can up-regulate MHC II expression and prime host peripheral lymphocytes for more severe rejection of transplanted organs and that this host immunogenic response is independent of tissue incompatibility and/or the type of ischemic insult.…”

Principles of Organ Preservation

“…It is also the only solution that is effective for prolonged preservation of isolated transplantable cells such as pancreatic islet cells. [12][13][14]…”