Twenty-Four-Hour Heart Preservation Using Continuous Cold Perfusion and Copper (II) Complexes

Sellke, Frank W.; Richter, Helen W.; Dunphy, Gail; Azodi, Masoud; Ely, Daniel

doi:10.1006/jsre.1998.5457

Cited by 3 publications

(1 citation statement)

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“…However, in most previous studies, subjects were small animals, which do not have a very similar anatomy and physiology to the human. Moreover, these studies used ex vivo nonworking Langendorff heart models for functional evaluation, instead of orthotopic transplanted hearts [1–8]. To assess whether CP preservation is superior to CS preservation, swine models were chosen for our study because of the similarities between human and swine in terms of anatomic and physiologic characteristics [9].…”

Section: Introductionmentioning

confidence: 99%

Continuous perfusion of donor hearts with oxygenated blood cardioplegia improves graft function

Zhang

Wen

et al. 2010

Transplant International

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Summary Donor hearts cannot be preserved beyond 6 h using cold storage (CS). Improving preservation methods may permit prolonged storage of donor heart. We compared graft function in large animal model after prolonged preservation (8 h) using continuous perfusion (CP) and CS method. Twenty‐four miniature pigs were used as donors and recipients. Donor hearts were either stored in University of Wisconsin solution (UW solution) for 8 h at 0–4 °C (CS group, n = 6) or were continuously perfused with oxygenated blood cardioplegia at 26 °C for 8 h (CP group, n = 6). After preservation, hearts were transplanted into recipients and reperfused for 3 h. Left ventricular (LV) function, cardiac output (CO), malondialdehyde (MDA) and adenosine triphosphate (ATP) levels, and water content were measured. Although water content of CP hearts was higher than that of CS, LV contractility and diastolic function of CP hearts were superior to those of CS. In addition, CP hearts performed better than CS hearts on CO in working heart state. ATP was better preserved and MDA levels were lower in CP hearts compared with those of CS (P < 0.0001). Donor hearts can be preserved longer using continuous perfusion with oxygenated blood cardioplegia and this method prevents time‐dependent ischemic injury.

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Section: Introductionmentioning

confidence: 99%