Twenty-four-hour pattern of mouse intraocular pressure

Aihara, Makoto; Lindsey, James D.; Weinreb, Robert N.

doi:10.1016/j.exer.2003.08.011

Cited by 93 publications

(84 citation statements)

References 32 publications

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“…Multivariate analysis showed no statistically significant differences in IOP values for female and male dogs [F (1,1680) Application of the periodic model and the statistical analysis of the cosinor procedure throughout the time series studied under the different experimental conditions, allowed us to ascertain the periodic pattern of IOP in both eyes (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

“…Some authors have reported higher IOP values at night than during the day, with a nocturnal peak value [41], while Jaén-Diaz et al [23] found higher IOP values in the morning than in the evening. In the mouse, rabbit, rat, chicken, and marmoset, the 24-h IOP pattern is biphasic when the animals are maintained on a 12/12 L/D cycle [1,31,33,34,42,45]. In the rabbit, it was found that there was a tendency toward an increase in the IOP in the morning with a sharp decline in the afternoon [24]; in the marmoset IOP was higher during the dark phase than the light phase [34], but IOP was not sampled at sufficient intervals to determine the precise phase or amplitude.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Different Artificial Lighting Regimes on Intraocular Pressure Circadian Profile in the Dog (<i>Canis familiaris</i>)

et al. 2010

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The present study was undertaken to determine the temporal variation in intraocular pressure (IOP) and if this variation is under circadian clock control. The authors exposed five female and five male Beagles to four different artificial lighting regimes: 12/12 light/dark (L/D) period, 12/12 D/L period, constant light, and constant darkness. IOP was measured at 3 h intervals over a 48-h period. Statistical analysis of the data was performed by multivariate ANOVA, one-way repeated measure ANOVA and by the single cosinor method. Results showed no statistical effect of gender, eye and photoperiod on IOP values. A significant effect of time for each gender and each eye during all lighting regimes was seen, except during constant light, and also robust daily rhythmicity of IOP values in all L/D periods, except during constant light. In conclusion IOP values in the dog show a circadian rhythm and this rhythm is driven by a central pacemaker.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Different Artificial Lighting Regimes on Intraocular Pressure Circadian Profile in the Dog (<i>Canis familiaris</i>)

et al. 2010

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“…Therefore, we examined the IOPs of WT, EAAC1 -/-, and GLAST -/-mice. IOP measurement was carried out for both young (4 week) and adult (9 to 11 month) mice around 9 pm, when IOP is highest in mouse eyes (18). The IOPs of EAAC1 -/-and GLAST -/-mice were not significantly increased compared with WT at both time points ( Figure 5I).…”

Section: Degeneration Of Rgcs In Glast-and Eaac1-deficient Micementioning

confidence: 99%

“…IOP was directly measured by a microneedle method in anesthetized mice as described previously (18,51). The microneedle was connected to a pressure transducer, which relayed its signal to a bridge amplifier and then to an analog-to-digital converter and a computer (World Precision Instruments).…”

Section: Figurementioning

confidence: 99%

The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma

Harada

Harada²,

Nakamura³

et al. 2007

J. Clin. Invest.

Self Cite

297

342

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Glaucoma, a progressive optic neuropathy due to retinal ganglion cell (RGC) degeneration, is one of the leading causes of irreversible blindness. Although glaucoma is often associated with elevated intraocular pressure (IOP), IOP elevation is not detected in a significant subset of glaucomas, such as normal tension glaucoma (NTG). Moreover, in some glaucoma patients, significant IOP reduction does not prevent progression of the disease. Thus, understanding IOP-independent mechanisms of RGC loss is important. Here, we show that mice deficient in the glutamate transporters GLAST or EAAC1 demonstrate spontaneous RGC and optic nerve degeneration without elevated IOP. In GLAST-deficient mice, the glutathione level in Müller glia was decreased; administration of glutamate receptor blocker prevented RGC loss. In EAAC1-deficient mice, RGCs were more vulnerable to oxidative stress. These findings suggest that glutamate transporters are necessary both to prevent excitotoxic retinal damage and to synthesize glutathione, a major cellular antioxidant and tripeptide of glutamate, cysteine, and glycine. We believe these mice are the first animal models of NTG that offer a powerful system for investigating mechanisms of neurodegeneration in NTG and developing therapies directed at IOP-independent mechanisms of RGC loss.

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“…Methods: Nine male Sprague-Dawley rats were exposed to a 12-hour light/dark cycle for 3 weeks. 24-hours IOP pattern was measured at six time points (8,12,16,20,24, and 4 circardian time) by Tonopen XL tonometer in awake state. After unilateral sympathectomy (cervical ganglionectomy), IOP measurements were performed at the same time points on post-operation 1, 2, 3, and 4 weeks.…”

mentioning

confidence: 99%

The Effect of Sympathectomy on Circardian Rhythm of Intraocular Pressure in Rat

Lim

Kim

Song

et al. 2008

J Korean Ophthalmol Soc

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Purpose: The present study was undertaken to determine the 24-hour pattern of intraocular pressure (IOP), and to reveal the effect of unilateral decentralization on circardian rhythm of IOP in eyes of rats. Methods: Nine male Sprague-Dawley rats were exposed to a 12-hour light/dark cycle for 3 weeks. 24-hours IOP pattern was measured at six time points (8,12,16,20,24, and 4 circardian time) by Tonopen XL tonometer in awake state. After unilateral sympathectomy (cervical ganglionectomy), IOP measurements were performed at the same time points on post-operation 1, 2, 3, and 4 weeks. Results: 24-hour IOP pattern of rats showed a rhythmic pattern that appeared to be sinusoidal with 12-hour light/dark cycle. IOPs were low during the light phase and high during dark phase. After unilateral sympathectomy, the circardian rhythm of IOP was maintained in control eyes. But in sympathecotmized eyes, the circardian thythm of IOP was loss. Conclusions: These results show that sympathetic nervous systems contribute to the circardian rhythm of IOP in rats.

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Twenty-four-hour pattern of mouse intraocular pressure

Cited by 93 publications

References 32 publications

Influence of Different Artificial Lighting Regimes on Intraocular Pressure Circadian Profile in the Dog (<i>Canis familiaris</i>)

Influence of Different Artificial Lighting Regimes on Intraocular Pressure Circadian Profile in the Dog (<i>Canis familiaris</i>)

The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma

The Effect of Sympathectomy on Circardian Rhythm of Intraocular Pressure in Rat

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