Twenty-Four-Hour Plasma Cortisol and Prolactin in Human African Trypanosomiasis Patients and Healthy African Controls

Radomski, M. W.; Buguet, Alain; Montmayeur, Alain; Bogui, Pascal; Bourdon, Lionel; Doua, F.; Lonsdorfer, A.; Tapie, P; Dumas, Michel

doi:10.4269/ajtmh.1995.52.281

Cited by 30 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sleeping sickness model is a condition character ized by a desynchronization of circadian rhythms of the sleep-wake cycle and secretions of cortisol and prolactin [13,14], these disruptions being proportional to the degree of severity of the disease. The rationale behind this study was to examine whether the temporal relationship between GH secretion and SWS [2,3] would persist under conditions of disrupted circadian rhythmicity and frag mented sleep-wake cycle as exist in sleeping sickness patients [13,14].…”

Section: Resultsmentioning

confidence: 99%

“…Similar results were found in the three most severely sick patients (PI. P2, P3), who had lost all circa dian rhythmicity in not only the sleep-wake cycle but also in cortisol and prolactin secretion [13,14],…”

Section: Resultsmentioning

confidence: 99%

“…The patients were ranked in terms of severity, the most severely ill patients being PI, P2 and P3. Details of the symptoms of the disease in the patients are given else where [13,14]. Due to the additional presence of severe diabetes in one of the patients (P5), his data were discarded from the study.…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

“…Sleeping sickness or human African trypanosomiasis, induced in humans by inoculation of Trypanosoma brucei gcimbiense by the tse-tse fly, is a unique disease condition in which disruptions in the circadian cycles of sleep and wakefulness [13], and the plasma levels of cortisol and prolactin (a sleep-related hormone) develop with the pro gression of the disease [14]. Hourly plasma levels of GH were assessed in the same patients as above [13,14] and compared to the occurrence of SWS.…”

Section: Introductionmentioning

confidence: 99%

“…Hourly plasma levels of GH were assessed in the same patients as above [13,14] and compared to the occurrence of SWS. Although we realized that this sampling frequency would blunt the detection of many GH pulses [5], the condition of the patients pre vented more frequent sampling.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Relationship of Plasma Growth Hormone to Slow-Wave Sleep in African Sleeping Sickness

Radomski¹,

Buguet

Doua³

et al. 1996

Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

Human African trypanosomiasis (sleeping sickness) is a unique disease model of disrupted circadian rhythms in the sleep-wake cycle and cortisol and prolactin secretion. This study examined the temporal relationship between growth hormone (GH) secretion and the sleep-wake cycle in 8 infected African patients and 6 healthy indigenous African subjects. Twenty-four-hour sleep patterns were recorded by polysomnography and hourly blood samples analyzed for plasma GH. No relationships between the mean normalized plasma GH levels (Z scores) and the sleep stages (wakefulness, sleep stages 1 and 2 (‘light’ sleep), slow-wave sleep (stages 3 and 4, SWS), and rapid eye movement (REM) sleep) were found in the patients or healthy subjects. However, when the time of sampling of the plasma GH concentrations was lagged by 16 min with respect to the occurrence of the various sleep stages, significant correlations were found between plasma GH concentrations and SWS in both healthy subjects and patients. Thus, the association between SWS and GH secretion persisted even in the presence of disrupted circadian rhythms, further supporting the concept that sleep and the stimulation of GH secretion are outputs of a common mechanism.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Aterials and M Ethodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Relationship of Plasma Growth Hormone to Slow-Wave Sleep in African Sleeping Sickness

Radomski¹,

Buguet

Doua³

et al. 1996

Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

African Trypanosomiasis

Black¹,

Seed²

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

View full text Add to dashboard Cite

Neuroendocrine Regulation of Growth Hormone Secretion

Steyn

Tolle

Chen

et al. 2016

Comprehensive Physiology

120

103

View full text Add to dashboard Cite

This article reviews the main findings that emerged in the intervening years since the previous volume on hormonal control of growth in the section on the endocrine system of the Handbook of Physiology concerning the intra- and extrahypothalamic neuronal networks connecting growth hormone releasing hormone (GHRH) and somatostatin hypophysiotropic neurons and the integration between regulators of food intake/metabolism and GH release. Among these findings, the discovery of ghrelin still raises many unanswered questions. One important event was the application of deconvolution analysis to the pulsatile patterns of GH secretion in different mammalian species, including Man, according to gender, hormonal environment and ageing. Concerning this last phenomenon, a great body of evidence now supports the role of an attenuation of the GHRH/GH/Insulin-like growth factor-1 (IGF-1) axis in the control of mammalian aging.

show abstract

Twenty-Four-Hour Plasma Cortisol and Prolactin in Human African Trypanosomiasis Patients and Healthy African Controls

Cited by 30 publications

References 0 publications

Relationship of Plasma Growth Hormone to Slow-Wave Sleep in African Sleeping Sickness

Relationship of Plasma Growth Hormone to Slow-Wave Sleep in African Sleeping Sickness

African Trypanosomiasis

Neuroendocrine Regulation of Growth Hormone Secretion

Contact Info

Product

Resources

About