Twenty-nail dystrophy and vitiligo: A rare association

Peloro, Tina M.; Pride, Howard B.

doi:10.1016/s0190-9622(99)70505-0

Cited by 21 publications

(24 citation statements)

References 13 publications

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“…However, for some of these cases, the clinical pictures show nail abnormalities that are different from trachyonychia (table 1). Vitiligo has also been associated with trachyonychia [20,21,22], but this probably reflects the fact that trachyonychia is commonly associated with alopecia areata. …”

Section: Resultsmentioning

confidence: 99%

Trachyonychia and Twenty-Nail Dystrophy: A Comprehensive Review and Discussion of Diagnostic Accuracy

Jacobsen

Tosti

2016

Skin Appendage Disord

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Background/Aims: The term trachyonychia, also known as twenty-nail dystrophy, is used to describe thin, brittle nails with excessive longitudinal ridging. The term twenty-nail dystrophy has been incorrectly applied to other conditions that can affect all twenty nails. Therefore, we have conducted a comprehensive review of the clinical features of trachyonychia and have included a discussion regarding the diagnostic accuracy of this condition in the literature. Methods: In November and December 2015, we conducted a thorough literature search using the following search terms: ‘trachyonychia', ‘twenty nail dystrophy', and ‘sandpaper nails'. Articles that reported the epidemiology, disease associations, clinical presentation, histopathology, and treatment options for trachyonychia were included. Particular attention was given to case reports to identify misdiagnosed cases of twenty-nail dystrophy. Results: Our preliminary search yielded 184 results with 72 unique articles ultimately selected for review. Excluded articles included 27 articles in languages other than English, 18 commentaries or reviews, and 67 irrelevant articles. Twelve additional articles described nail abnormalities clinically different from trachyonychia. Conclusion: Many other conditions can cause widespread nail dystrophy. The specific characteristics of trachyonychia need to be considered to make the diagnosis of twenty-nail dystrophy.

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Section: Resultsmentioning

confidence: 99%

Trachyonychia and Twenty-Nail Dystrophy: A Comprehensive Review and Discussion of Diagnostic Accuracy

Jacobsen

Tosti

2016

Skin Appendage Disord

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“…Rare associations with vitiligo and incontinentia pigmenti have also been reported. 5,6 Trachyonychia may be idiopathic, that is, without associated dermatological disease. 2 Localized trachyonychia in a judo player from the repeated grabbing of opponents' uniforms has been described.…”

Section: Discussionmentioning

confidence: 99%

Follow up of 12 patients with trachyonychia

et al. 2006

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A follow-up study was performed to determine the outcomes of all patients (five males and seven females, mean age 18.4 years) who were referred to a specialist nail clinic with trachyonychia. The average number of affected nails per patient was 8.8 fingernails and 6.2 toenails. None of our patients tested positive for onychomycosis. Nail biopsies were performed in two patients, revealing non-specific changes. Eight patients did not present with or develop accompanying skin or mucosal disease. Two patients presented with alopecia areata and two others with psoriasis. Of our patients, 50% showed total resolution or marked improvement in their nail disease within the first 6 years regardless of treatment.

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“…[5] Trachyonychia may present as an idiopathic disorder of the nails with no other cutaneous or systemic findings or it can be caused by a variety of other disorders. [2,10,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] It has been reported in association with several diseases such as vitiligo [32] and atopic dermatitis, [31] which are also seen in association with alopecia areata (AA). [10] It is the opinion of the reviewer that these cases most likely represent alopecia areata of the nails.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Alopecia areata [10] Atopic dermatitis [31] Autoimmune hemolytic anemia [18] Bart syndrome [19] Congential cutaneous candidiasis [19] Dyskeratosis congenita (Zinsser-Engman-Cole syndrome) [19] Graft-versus host disease [20] Hereditary punctuate palmoplantar keratoderma (Brauer-Buschke-Fischer syndrome) [19] Hidrotic ectodermal dysplasia (Clouston syndrome) [19] Ichthyosis vulgaris [21] Idiopathic thrombocytopenic purpura [18] Immunoglobulin A deficiency [22] Incontinentia pigmenti [23] Koilonychia [24] Lichen planus [25] Nail-Patella syndrome [19] Onychodysplasia of the index fingers [19] Pachyonychia congenita [19] Pemphigus vulgaris [26] Primary biliary cirrhosis [27] Psoriasis [28] Sarcoidosis [29] Trauma [30] Vitiligo [32] acanthosis, focal parakeratosis, and the accumulation of polymorphonuclear cells along the dorsal nail plate. [2] From a morphological point of view, patients who develop trachyonychia in the setting of psoriasis have more thickening of the nail plate as opposed to the thinning seen in lichen planus.…”

Section: Clinical Featuresmentioning

confidence: 99%

Trachyonychia: A comprehensive review

Gordon¹,

Vega²,

Tosti³

2011

Indian J Dermatol Venereol Leprol

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Trachyonychia or rough nails, may present as an idiopathic disorder of the nails or it can be associated with other dermatological conditions. The dystrophic nail findings seen in trachyonychia are characterized by brittle, thin nails, with excessive longitudinal ridging. The most common histopathologic features associated with trachyonychia are spongiosis and exocytosis of inflammatory cells into the nail epithelia; typical features of lichen planus or psoriasis can also be detected. Determining the cause of trachyonychia is challenging. Treatment is often unsatisfactory, although in general it should be aimed at the underlying cause, if found. In most cases, the nail abnormalities improve spontaneously.

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Twenty-nail dystrophy and vitiligo: A rare association

Cited by 21 publications

References 13 publications

Trachyonychia and Twenty-Nail Dystrophy: A Comprehensive Review and Discussion of Diagnostic Accuracy

Trachyonychia and Twenty-Nail Dystrophy: A Comprehensive Review and Discussion of Diagnostic Accuracy

Follow up of 12 patients with trachyonychia

Trachyonychia: A comprehensive review

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