2023
DOI: 10.3390/cells12050737
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Twenty Novel MicroRNAs in the Aqueous Humor of Pseudoexfoliation Glaucoma Patients

Abstract: The microRNAs (miRNAs) are short non-coding RNAs (19–25 nt) that regulate the level of gene expression at the post-transcriptional stage. Altered miRNAs expression can lead to the development of various diseases, e.g., pseudoexfoliation glaucoma (PEXG). In this study, we assessed the levels of miRNA expression in the aqueous humor of PEXG patients using the expression microarray method. Twenty new miRNA molecules have been selected as having the potential to be associated with the development or progression of… Show more

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Cited by 6 publications
(2 citation statements)
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“…These miRNAs target genes involved in the pathophysiology of glaucoma, such as SMAD3/2. Similarly, Czop et al [82] examined miRNA expression in the AH of patients with pseudoexfoliative glaucoma (PEXG) through using microarrays. They identified twenty differentially expressed miRNAs associated with PEXG, including ten downregulated (e.g., hsa-miR-95-5p) and ten upregulated (e.g., hsa-miR-202-3p) miRNAs.…”
Section: Mirna Expression Patterns In Glaucomamentioning
confidence: 99%
“…These miRNAs target genes involved in the pathophysiology of glaucoma, such as SMAD3/2. Similarly, Czop et al [82] examined miRNA expression in the AH of patients with pseudoexfoliative glaucoma (PEXG) through using microarrays. They identified twenty differentially expressed miRNAs associated with PEXG, including ten downregulated (e.g., hsa-miR-95-5p) and ten upregulated (e.g., hsa-miR-202-3p) miRNAs.…”
Section: Mirna Expression Patterns In Glaucomamentioning
confidence: 99%
“…Recently, mutations in the lysyl oxidase-like 1 gene ( LOXL1 ) at the locus 15q22 have been identified as the major contributing factor to the fibrotic disorder seen in PEX syndrome [ 12 , 13 ]. Many other gene variants or mutations can potentially be associated with the development of this condition, including the clusterin gene, calcium voltage-gated channel subunit alpha 1 gene variants, glutathione transferase gene, fibulin-5 gene, tumor necrosis factor-alpha, and tumor growth factor beta 1, as well as the presence of altered microRNA molecules, which regulate post-transcriptional gene expression, in the aqueous humor of individuals with PEX [ 3 , 14 ].…”
Section: Introductionmentioning
confidence: 99%