Twenty-year brain magnetic resonance imaging follow-up study in Systemic Lupus Erythematosus: Factors associated with accrual of damage and central nervous system involvement

Piga, Matteo; Peltz, Maria Teresa; Montaldo, C; Perra, Daniela; Sanna, Giovanni; Cauli, Alberto; Mathieu, Alessandro

doi:10.1016/j.autrev.2015.01.010

Cited by 35 publications

(26 citation statements)

References 57 publications

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“…Longitudinally, a 20-year MRI follow-up study showed increased number and volume of WMHs and brain volume loss in most of 30 SLE patients studied, but may have reflected mainly ageing effects. 29 In a shorter follow-up study of 75 SLE patients, predictors of new or increased WMH included antiphospholipid antibodies, SLE damage scores, and higher dose of corticosteroids (possibly a marker of higher disease activity), and there was more gray and white matter volume loss versus controls. 30,31 …”

Section: Discussionmentioning

confidence: 99%

Cerebral Small Vessel Disease Burden Is Increased in Systemic Lupus Erythematosus

Wiseman

Bastin

Jardine

et al. 2016

Stroke

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Section: Discussionmentioning

confidence: 99%

Cerebral Small Vessel Disease Burden Is Increased in Systemic Lupus Erythematosus

Wiseman

Bastin

Jardine

et al. 2016

Stroke

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“…The study revealed an MRI sensitivity of 0.64, positive predictive value of 0.76, negative predictive value of 0.83 and area under the curve of 0.71 for diagnosis of brain abnormalities in SLE patients. Recent studies report a prevalence of neuropsychiatric manifestations of 27-80% in adults, and 22-95% in children with SLE [16][17][18][19][20][21][22]. One study reported that the sensitivity and specificity of MRI in detecting the brain abnormalities in SLE patients was 30% and 40%, respectively [17].…”

Section: Discussionmentioning

confidence: 99%

“…One study reported that the sensitivity and specificity of MRI in detecting the brain abnormalities in SLE patients was 30% and 40%, respectively [17]. Another study reported that 80% of longstanding SLE patients had abnormal brain MRI [16] and another study added that abnormal MRI was reported in 47.2% of patients with diffuse NPSLE [18].…”

Section: Discussionmentioning

confidence: 99%

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Magnetic resonance imaging (MRI) brain abnormalities of neuropsychiatric systemic lupus erythematosus patients in Mansoura city: Relation to disease activity

Zaky

Shaat

El-Bassiony

et al. 2015

The Egyptian Rheumatologist

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Aim of the work: To assess brain abnormalities in neuropsychiatric systemic lupus erythematosus (NPSLE) patients using magnetic resonance imaging (MRI) and to compare the findings to those in SLE patients without neuropsychiatric manifestations as well as to compare disease activity between SLE patients with and without MRI brain abnormalities.Patients and methods: The study was conducted on 55 SLE patients (48 female/7 male) with a mean age of 27.3 ± 4.6 years and disease duration of 4 ± 1.6 years. Patients with NPSLE (n = 30) and without neuropsychiatric (no-NPSLE) (n = 25) underwent MRI brain. The SLE disease activity index (SLEDAI), headache disability index and mini mental state score were considered.Results: Brain abnormalities were detected in 21 SLE patients (38.2%); 16 NPSLE and 5 no-NPSLE. The brain abnormalities included a significantly higher frequency of white matter changes in NPSLE (14 patients; 46%) compared to no-NPSLE patients (5 patients; 20%) (p = 0.038). In NPSLE patients, ischemia was present in 5 patients (16.7%), hemorrhage in 3 (10%) and encephalopathy in another 3 (10%). The SLEDAI was significantly higher in NPSLE patients with cognitive impairment(33.6 ± 9.1) and NPSLE patients with headache (24.2 ± 5.6) compared to the score in no-NPSLE patients (7.2 ± 4.7) (p = 0.001). Patients with MRI brain abnormalities had significantly longer disease duration (p = 0.03), higher SLEDAI (p = 0.001), mini mental state score (p = 0.005) and headache score (p = 0.019) than those without. The study revealed an MRI sensitivity of 0.64.

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“…In particular, the study recently published by Zimmerman and colleagues demonstrated a reduced temporal lobe structure in SLE patients with cognitive dysfunction compared with those without cognitive deficits [15]. Moreover, MRI could be used to longitudinally assess SLE patients: in a recently published study, the MRI evaluation at baseline and after 20 years of follow-up demonstrated the progression of MRI brain damage in SLE patients independently from neuropsychiatric involvement; moreover, this progression seemed to be associated with increased risk of new events [16].…”

Section: Neuropsychiatric Involvementmentioning

confidence: 98%

Developing new evaluation methods in systemic lupus erythematosus

Ceccarelli

Alessadri

Scavalli

et al. 2015

International Journal of Clinical Rheumatology

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Monitoring systemic lupus erythematosus (SLE) requires comprehensive assessment\ud of disease activity, comorbidities, chronic damage and patients’ perspective of the\ud disease. This narrative review summarizes the innovative and currently available tools\ud to assess SLE patients in clinical research and routine practice setting focusing on what\ud is new in the assessment of disease activity and damage, discussing composite indices\ud and organ-specific scores; a separate section is dedicated to the imaging techniques\ud useful to assess neuropsychiatric, musculoskeletal and renal involvement. SLE-related\ud chronic damage and comorbid conditions contributing to patients’ illness and longterm\ud outcome are discussed. Finally, the impact of SLE on patients’ quality of life is\ud addressed focusing on self-reported questionnaires, adherence to treatment and\ud work ability

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Twenty-year brain magnetic resonance imaging follow-up study in Systemic Lupus Erythematosus: Factors associated with accrual of damage and central nervous system involvement

Cited by 35 publications

References 57 publications

Cerebral Small Vessel Disease Burden Is Increased in Systemic Lupus Erythematosus

Cerebral Small Vessel Disease Burden Is Increased in Systemic Lupus Erythematosus

Magnetic resonance imaging (MRI) brain abnormalities of neuropsychiatric systemic lupus erythematosus patients in Mansoura city: Relation to disease activity

Developing new evaluation methods in systemic lupus erythematosus

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