Twenty-Year Follow-up Study Comparing Operative Versus Nonoperative Treatment of Anterior Cruciate Ligament Ruptures in High-Level Athletes

Yperen, Daan T van; Reijman, Max; Es, Eline M. van; Bierma-Zeinstra, Sita M A; Meuffels, Duncan E.

doi:10.1177/0363546517751683

Cited by 98 publications

(96 citation statements)

References 47 publications

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“…Five percent of all people had suffered a previous ACL injury, and 2% went on to suffer a subsequent contralateral ACL injury. Following ACLR, graft rupture occurred in 5% of people, which is consistent with previously reported graft rupture rates (Crawford et al, 2013;Lai et al, 2017;van Yperen, Reijman, van Es, Bierma-Zeinstra, & Meuffels, 2018;Wright et al, 2011).…”

Section: Subsequent Acl Injurysupporting

confidence: 90%

Physiotherapy treatment and rehabilitation following anterior cruciate ligament injury in New Zealand: Are we doing enough?

Fausett¹,

Wilkins²,

Reid³

et al. 2019

NZJP

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Physiotherapists are lead providers of rehabilitation following anterior cruciate ligament injury in New Zealand. Rehabilitation is considered an essential component following anterior cruciate ligament injuries, but there is considerable variability regarding preand post-operative management. This study used data from the Accident Compensation Corporation (ACC) for the years 2013/14 to 2015/16 to gain insight into the physiotherapy management of anterior cruciate ligament injuries in New Zealand. Data were extracted from 647 claims from people with a completed anterior cruciate ligament reconstruction and 221 claims from people with a confirmed injury who did not undergo surgery. In the 12 months following either anterior cruciate ligament injury or surgery, 81% of claimants had fewer than 15 ACC-funded physiotherapy treatments, and 13% of claimants had no ACC-funded physiotherapy treatments. Nine percent of claimants had a previous or subsequent claim for an anterior cruciate ligament injury. Compared to best practice literature, the results indicate a significant number of people in New Zealand received fewer than the recommended number of physiotherapy treatments following anterior cruciate ligament injury. Possible reasons may include the cost of private physiotherapy services, a lack of endorsement from the respective orthopaedic surgeons, decreased patient adherence/motivation and decreased patient understanding of the importance of rehabilitation.

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Section: Subsequent Acl Injurysupporting

confidence: 90%

Physiotherapy treatment and rehabilitation following anterior cruciate ligament injury in New Zealand: Are we doing enough?

Fausett¹,

Wilkins²,

Reid³

et al. 2019

NZJP

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“…Thus, the latter type of data is underpowered to disentangle whether clinically assessed alterations of the knee joint during rehabilitation from ACL reconstruction are due to surgery and physical activity or the individual musculoskeletal biology of the patient. Last, but not least, the open reconstructive surgery, and the post-operative cast immobilization ( Smith and Davies, 2008 ), deployed does not correspond to the state-of-art to address the studied clinical problem, which in instances is treated nowadays in a conservative manner despite a similar long term outcome as a surgical approach ( Culvenor et al, 2013 ; van Yperen et al, 2018 ). Within these mentioned boundaries, our manuscript provides novel relevant insight on the molecular and cellular mechanism underling the course of recovery of knee extensor function after open knee surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Routine clinical measurements were performed ( Gerber et al, 1985 ; Domnick et al, 2016 ; van Yperen et al, 2018 ). Knee stability and ACL injury was estimated with Lachmann and drawer test, the Pivot shift test, and by a radiological evaluation.…”

Section: Methodsmentioning

confidence: 99%

Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Open Knee Surgery

et al. 2018

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We investigated molecular and cellular parameters which set metabolic and mechanical functioning of knee extensor muscles in the operated and contralateral control leg of 9 patients with a chronically insufficient anterior cruciate ligament (ACL; 26.6 ± 8.3 years, 8 males, 1 female) after open reconstructive surgery (week 0), after ambulant physiotherapy under cast immobilization (week 9), succeeding rehabilitation training (up to week 26), and subsequent voluntary physical activity (week 260). Clinical indices of knee function in the operated leg were improved at 52 weeks and remained at a comparable level at week 260. CSA of the quadriceps (-18%), MCSA of muscle fibers (-24%), and capillary-to-fiber ratio (-24%) in m. vastus lateralis from the ACL insufficient leg were lower at week 0 than reference values in the contralateral leg at week 260. Slow type fiber percentage (-35%) and mitochondrial volume density (-39%) were reduced in m. vastus lateralis from the operated leg at weeks 9 and 26. Composition alterations in the operated leg exceeded those in the contralateral leg and, with the exception of the volume density of subsarcolemmal mitochondria, returned to the reference levels at week 260. Leg-specific deterioration of metabolic characteristics in the vasti from the operated leg was reflected by the down-regulation of mitochondrial respiration complex I-III markers (-41–57%) at week 9. After rehabilitation training at week 26, the specific Y397 phosphorylation of focal adhesion kinase (FAK), which is a proxy for mechano-regulation, was elevated by 71% in the operated leg but not in the contralateral leg, which had performed strengthening type exercise during ambulant physiotherapy. Total FAK protein and Y397 phosphorylation levels were lowered in both legs at week 26 resulting in positive correlations with mitochondrial volume densities and mitochondrial protein levels. The findings emphasize that a loss of mechanical and metabolic characteristics in knee extensor muscle remains detectable years after untreated ACL rupture, which may be aggravated in the post-operative phase by the deterioration of slow-oxidative characteristics after reconstruction due to insufficient load-bearing muscle activity. The reestablishment of muscle composition subsequent to years of voluntary physical activity reinforces that slow-to-fast fiber transformation is reversible in humans.

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“…Eleven of the included studies 21 27 28 37 39 40 45-48 53 reported radiographic OA prevalence in the contralateral knee, ranging from 2% to 38%. Of these, five studies reported results from uninjured contralateral knees, 27 28 45 48 53 four studies 21 39 40 42 reported additional injuries to the contralateral knee (ACL injury, chondral lesion, meniscal injury, medial collateral ligament and lateral collateral ligament injury), while three studies 37 46 47 did not provide any information regarding additional injuries to the contralateral knee.…”

Section: Prevalence Of Radiographic Oamentioning

confidence: 99%

What’s the rate of knee osteoarthritis 10 years after anterior cruciate ligament injury? An updated systematic review

Risberg²,

et al. 2019

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BackgroundThis updated systematic review reports data from 2009 on the prevalence, and risk factors, for knee osteoarthritis (OA) more than 10 years after anterior cruciate ligament (ACL) tear.MethodsWe systematically searched five databases (PubMed, EMBASE, AMED, Cinahl and SPORTDiscus) for prospective and retrospective studies published after 1 August 2008. Studies were included if they investigated participants with ACL tear (isolated or in combination with medial collateral ligament and/or meniscal injuries) and reported symptomatic and/or radiographic OA at a minimum of 10 years postinjury. We used a modified version of the Downs and Black checklist for methodological quality assessment and narrative synthesis to report results. The study protocol was registered in PROSPERO.ResultsForty-one studies were included. Low methodological quality was revealed in over half of the studies. At inclusion, age ranged from 23 to 38 years, and at follow-up from 31 to 51 years. Sample sizes ranged from 18 to 780 participants. The reported radiographic OA prevalence varied between 0% and 100% >10 years after injury, regardless of follow-up time. The studies with low and high methodological quality reported a prevalence of radiographic OA between 0%–100% and 1%–80%, respectively. One study reported symptomatic knee OA for the tibiofemoral (TF) joint (35%), and one study reported symptomatic knee OA for the patellofemoral (PF) joint (15%). Meniscectomy was the only consistent risk factor determined from the data synthesis.ConclusionRadiographic knee OA varied between 0% and 100% in line with our previous systematic review from 2009. Symptomatic and radiographic knee OA was differentiated in two studies only, with a reported symptomatic OA prevalence of 35% for the TF joint and 15% for PF joint. Future cohort studies need to include measurement of symptomatic knee OA in this patient group.PROSPERO registration numberCRD42016042693.

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Twenty-Year Follow-up Study Comparing Operative Versus Nonoperative Treatment of Anterior Cruciate Ligament Ruptures in High-Level Athletes

Cited by 98 publications

References 47 publications

Physiotherapy treatment and rehabilitation following anterior cruciate ligament injury in New Zealand: Are we doing enough?

Physiotherapy treatment and rehabilitation following anterior cruciate ligament injury in New Zealand: Are we doing enough?

Knee Extensors Muscle Plasticity Over a 5-Years Rehabilitation Process After Open Knee Surgery

What’s the rate of knee osteoarthritis 10 years after anterior cruciate ligament injury? An updated systematic review

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