Twenty-Year Survivors of Kidney Transplantation

Traynor, Carol; Jenkinson, Allan; Williams, Yvonne; O’Kelly, Patrick; Hickey, David P.; Denton, Mark D.; Magee, Colm; Conlon, Peter J.

doi:10.1111/j.1600-6143.2012.04236.x

Cited by 61 publications

(61 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The authors concluded that in these long-term kidney graft survivals, the focus of management should be on the prevention of cancers and CVD, as the prevalence was very high in these patients. In another study, the most common causes of death among KTRs 20 years after transplantation were CVD and malignancy [21]. As with our study, a higher incidence of cancer and CVD was found among 2,202 KTRs even 10 years after transplantation [22].…”

Section: Discussionsupporting

confidence: 73%

Characteristics and Outcomes of Kidney Transplant Recipients with a Functioning Graft for More than 25 Years

et al. 2018

View full text Add to dashboard Cite

Background: Information regarding the clinical characteristics and outcomes of kidney transplant recipients (KTRs) with > 25 years of graft survival is limited. Methods: In this single-center observational study, we characterized KTRs transplanted between 1973 and 1992 with active follow-up as of July 31, 2017. Results: We identified 112 patients with > 25 years of allograft function. The mean posttransplantation follow-up was 29.8 ± 4.0 years. Glomerulonephritis was the most common cause of end-stage renal disease (ESRD) (52%). The majority received live donor transplants (66%), including 25 patients (22%) with human leukocyte antigen-matched kidneys. The incidence of biopsy-confirmed acute rejection was 21%, ranging from 0 to 26 years post transplantation. Donor-specific antibodies (DSA) were checked in 80% of patients at a mean of 28.4 ± 0.11 years post transplantation. Of these, only 15% were positive. The incidence of malignancy was 44%, with nonmelanoma skin cancers being most common. The incidence of infectious complications was 77%, mostly represented by urinary tract infections. At the time of last follow-up, 63% were on a calcineurin inhibitor (CNI)-free regimen, mean serum creatinine was 1.4 ± 0.6 mg/dL, and the prevalence of hypertension and dyslipidemia was 89 and 88%, respectively. Conclusion: The majority of patients with a long-term functioning graft had glomerulonephritis as cause of ESRD, had received a live donor kidney, were on a CNI-free regimen, and had a low incidence of DSA and opportunistic infections. These characteristics define a unique group of patients requiring specific posttransplantation monitoring and management.

show abstract

Section: Discussionsupporting

confidence: 73%

Characteristics and Outcomes of Kidney Transplant Recipients with a Functioning Graft for More than 25 Years

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Advancements in renal transplantation over the past 3 decades have widened access to transplantation for individuals with end-stage renal disease and improved both graft and recipient survival (1,2). The growing population of RTRs on the Island of Ireland, therefore, requires surveillance to detect when any new aspect of clinical management poses a risk factor for cancer.…”

Section: Discussionmentioning

confidence: 99%

Surveillance of Nonmelanoma Skin Cancer Incidence Rates in Kidney Transplant Recipients in Ireland

Bannon

McCaughan²,

Traynor³

et al. 2014

Transplantation

View full text Add to dashboard Cite

show abstract

“…Therefore, compared with the 5-year survivals (70-80%) of other organs (kidney, islet, heart, etc.) [45][46][47], the survival of corneal allotransplantation is not high, except in patients with keratoconus. The patient with corneal blindness does not have any option except transplantation.…”

Section: Quality Control Of Porcine Corneal Productsmentioning

confidence: 99%

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation

Kim

Choi

Kwon

et al. 2014

Xenotransplantation

View full text Add to dashboard Cite

To develop an international consensus regarding the appropriate conditions for undertaking clinical trials in xenocorneal transplantation, here we review specific ethical, logistical, scientific, and regulatory issues regarding xenocorneal transplantation, and propose guidelines for conduct of clinical xenocorneal transplantation trials. These proposed guidelines are modeled on the published consensus statement of the International Xenotransplantation Association regarding recommended guidelines for conduct of clinical islet xenotransplantation. It is expected that this initial consensus statement will be revised over time in response to scientific advances in the field, and changes in the regulatory framework based on accumulating clinical experience.

show abstract

Twenty-Year Survivors of Kidney Transplantation

Cited by 61 publications

References 14 publications

Characteristics and Outcomes of Kidney Transplant Recipients with a Functioning Graft for More than 25 Years

Characteristics and Outcomes of Kidney Transplant Recipients with a Functioning Graft for More than 25 Years

Surveillance of Nonmelanoma Skin Cancer Incidence Rates in Kidney Transplant Recipients in Ireland

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation

Contact Info

Product

Resources

About