Twenty years of islet-on-a-chip: microfluidic tools for dissecting islet metabolism and function

Regeenes, Romario; Rocheleau, Jonathan V.

doi:10.1039/d3lc00696d

Lab Chip

2024

DOI: 10.1039/d3lc00696d

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Twenty years of islet-on-a-chip: microfluidic tools for dissecting islet metabolism and function

Romario Regeenes,

Jonathan V. Rocheleau

Abstract: Islet-on-a-chip devices have the power to measure pancreatic islet metabolism from donor and engineered islets. These measurements could be used to determine healthy islets for the treatment of type 1 diabetes.

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Cited by 6 publications

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Organ‐On‐A‐Chip Devices: Technology Progress and Challenges

Obeid,

Yammine,

El‐Nakat

et al. 2024

ChemBioChem

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Organ‐On‐a‐Chip (OOC) is a multichannel 3D‐microfluidic cell‐culture system incorporated in a chip that simulates the behavior of an organ. This technology relies on a multidisciplinary science that benefits from and contributes in the progress of many fields including microbiology, microfluidics, biomaterials, and bioengineering. This review article summarizes the progress and achievements of various organ‐on‐chip technologies. It highlights the significant advantages of this technology in terms of reducing animal testing and providing personalized medical responses. In addition, this paper demonstrates how OOC is becoming a promising and powerful tool in pharmaceutical research to combat diseases. It predicts not only the effects of drugs on the target organs but also, using body‐on‐a‐chip systems, it may provide insights into the side effects of the drug delivery on the other organs. Likewise, the models used for the construction of various organ‐on‐a‐chip devices are investigated along with the design and materials of microfluidic devices. For each OOC, the integrated monitoring devices within the chips (e. g., sensors and biosensors) are discussed. We also discuss the evolution of FDA regulations and the potential in the near future for integrating OOCs into protocols that support and reduce the need for and the failure rates in preclinical and clinical studies.

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Organ‐On‐A‐Chip Devices: Technology Progress and Challenges

Obeid,

Yammine,

El‐Nakat

et al. 2024

ChemBioChem

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Engineered microenvironments and pancreatic islet-on-chips for screening sugar substitute and antidiabetic compounds

Shi,

Li,

et al. 2024

Food Research International

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Vascular and immune interactions in islets transplantation and 3D islet models

Migliorini,

Nostro

2024

Current Opinion in Genetics & Development

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Twenty years of islet-on-a-chip: microfluidic tools for dissecting islet metabolism and function

Abstract: Islet-on-a-chip devices have the power to measure pancreatic islet metabolism from donor and engineered islets. These measurements could be used to determine healthy islets for the treatment of type 1 diabetes.

Cited by 6 publications

References 114 publications

Organ‐On‐A‐Chip Devices: Technology Progress and Challenges

Organ‐On‐A‐Chip Devices: Technology Progress and Challenges

Engineered microenvironments and pancreatic islet-on-chips for screening sugar substitute and antidiabetic compounds

Vascular and immune interactions in islets transplantation and 3D islet models

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