Twice‐a‐day radiotherapy for T3 squamous cell carcinoma of the glottic larynx

Abstract

Between March 1978 and April 1986, 21 previously untreated patients with T3 squamous cell carcinoma of the true vocal cord received radical courses of twice-a-day radiotherapy (120 cGy twice daily) to total doses of 7,440-7,680 cGy. The rate of local control at the primary site was 67% after radiotherapy. The ultimate control rate after salvage surgery was 83%. Five-year absolute and cause-specific survival rates were 59% and 81%, respectively. It is concluded that radiotherapy is a rational approach for many patients with T3 glottic cancer.

Advanced larynx cancer

“…Similar survival rates and ultimate locoregional control have been reported when surgery for salvage is included [17]. Parsons et al [18] reported on hyperfractionated RT to total doses of 7440 cGy to 7680 cGy, with a local control rate of 67% and an ultimate control rate after surgical salvage of 83%. The authors prefer not to use definitive RT if the patient is a candidate for conservation surgery and might not otherwise need radiotherapy.…”

Results of 226 patients with T3 laryngeal carcinoma after treatment with transoral laser microsurgery

“…For primary (chemo)radiotherapy, 5‐year local control rates of 30% to 68% are reported for T3 glottic carcinomas. The 5‐year overall survival rate is 51% to 59% and the 5‐year rate for larynx preservation is 50% to 76% . Solares et al investigated 14 patients with T3 glottic carcinoma after treatment with chemoradiotherapy.…”

Functional organ preservation in laryngeal and hypopharyngeal cancer

“…The 5-year overall survival rate is 51%–59%. The 5-year larynx preservation rate is 60%–76% [102], [109], [110], [111]. …”