Twice Bitten, Thrice Shy

Wiltshire, S.; Nadel, James; Meredith, T.; Iglesias, Cassia Kessler; Qiu, Min; Macdonald, Peter S.; Jabbour, Andrew

doi:10.1016/j.jaccas.2020.11.025

Cited by 5 publications

(1 citation statement)

References 9 publications

(11 reference statements)

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“…If we assume the existence of isolated CS, we should stipulate the presence of a tissue‐specific myocardial predisposition as well as the nature of CS as a “second hit” disease in analogy to other acquired cardiomyopathies, such as alcoholic‐induced dilated cardiomyopathy 28 or acquired long QT syndrome 29 showing classical mutations in genes encoding different myocardial proteins. On the other hand, there are observations supporting the theory of misclassification, such as the report by Wiltshire and colleagues that showed recurrent isolated CS in a transplanted heart, 30 an unlikely finding in an isolated cardiac condition.…”

Section: Does Isolated Cs Exist?mentioning

confidence: 94%

Pathophysiological Gaps, Diagnostic Challenges, and Uncertainties in Cardiac Sarcoidosis

Ueberham

Hagendorff

Klingel

et al. 2023

JAHA

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Cardiac sarcoidosis can mimic any cardiomyopathy in different stages. Noncaseating granulomatous inflammation can be missed, because of the nonhomogeneous distribution in the heart. The current diagnostic criteria show discrepancies and are partly nonspecific and insensitive. Besides the diagnostic pitfalls, there are controversies in the understanding of the causes, genetic and environmental background, and the natural evolution of the disease. Here, we review the current pathophysiological aspects and gaps that are relevant for future cardiac sarcoidosis diagnostics and research.

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Section: Does Isolated Cs Exist?mentioning

confidence: 94%