Twice vs three times daily antibiotics in the treatment of pulmonary exacerbations of cystic fibrosis

Smyth, Alan; Knox, Alan J.

doi:10.1016/j.jcf.2011.03.010

Cited by 2 publications

(3 citation statements)

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“…( 51 , 52 ) Given that P. aeruginosa is a pathogen that develops resistance to antimicrobial agents relatively easily,( 53 ) the combination of drugs with different mechanisms of action can contribute to minimizing this risk. In a study conducted in England, the researchers reported a high prevalence of ceftazidime-resistant P. aeruginosa strains, possibly due to the practice of monotherapy with this drug in the institution (LE 4).…”

Section: Methodsmentioning

confidence: 99%

“…( 51 , 52 ) A P. aeruginosa é um patógeno que desenvolve resistência aos antimicrobianos com relativa facilidade,( 53 ) de tal modo que a combinação de drogas com mecanismos de ação distintos pode contribuir para minimizar esse risco. Em um estudo na Inglaterra, os pesquisadores relataram uma alta prevalência de uma cepa de P. aeruginosa resistente à ceftazidima, possivelmente decorrente da prática de monoterapia com essa droga na instituição (NE 4).…”

Section: Métodosunclassified

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Pseudomonas aeruginosa infection in patients with cystic fibrosis: scientific evidence regarding clinical impact, diagnosis, and treatment

et al. 2013

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Evidence-based techniques have been increasingly used in the creation of clinical guidelines and the development of recommendations for medical practice. The use of levels of evidence allows the reader to identify the quality of scientific information that supports the recommendations made by experts. The objective of this review was to address current concepts related to the clinical impact, diagnosis, and treatment of Pseudomonas aeruginosa infections in patients with cystic fibrosis. For the preparation of this review, the authors defined a group of questions that would be answered in accordance with the principles of PICO–an acronym based on questions regarding the Patients of interest, Intervention being studied, Comparison of the intervention, and Outcome of interest. For each question, a structured review of the literature was performed using the Medline database in order to identify the studies with the methodological design most appropriate to answering the question. The questions were designed so that each of the authors could write a response. A first draft was prepared and discussed by the group. Recommendations were then made on the basis of the level of scientific evidence, in accordance with the classification system devised by the Oxford Centre for Evidence-Based Medicine, as well as the level of agreement among the members of the group.

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Section: Methodsmentioning

confidence: 99%

Section: Métodosunclassified

Pseudomonas aeruginosa infection in patients with cystic fibrosis: scientific evidence regarding clinical impact, diagnosis, and treatment

et al. 2013

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“…Inhaled aminoglycosides are a guideline-recommended therapy for many patients with chronic P. aeruginosa airway infection (Mogayzel et al, 2013). The standard of care for patients receiving aminoglycosides for treatment of a CF exacerbation is one intravenous (IV) infusion of tobramycin per day (Smyth et al, 2005;Smyth and Knox , 2011;Smyth and Bhatt, 2012).…”

Section: Introductionmentioning

confidence: 99%